TFF3_PIG
ID TFF3_PIG Reviewed; 80 AA.
AC Q29183;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 23-FEB-2022, entry version 69.
DE RecName: Full=Trefoil factor 3;
DE AltName: Full=Intestinal trefoil factor;
DE Flags: Precursor;
GN Name=TFF3; Synonyms=ITF;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=8672129; DOI=10.1007/s003359900153;
RA Winteroe A.K., Fredholm M., Davies W.;
RT "Evaluation and characterization of a porcine small intestine cDNA library:
RT analysis of 839 clones.";
RL Mamm. Genome 7:509-517(1996).
CC -!- FUNCTION: Involved in the maintenance and repair of the intestinal
CC mucosa. Promotes the mobility of epithelial cells in healing processes
CC (motogen) (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer. Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250|UniProtKB:Q07654}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q07654}.
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DR EMBL; F14493; CAA23086.1; -; mRNA.
DR STRING; 9823.ENSSSCP00000024677; -.
DR PaxDb; Q29183; -.
DR PeptideAtlas; Q29183; -.
DR eggNOG; ENOG502SV7V; Eukaryota.
DR InParanoid; Q29183; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00111; Trefoil; 1.
DR Gene3D; 4.10.110.10; -; 1.
DR InterPro; IPR017994; P_trefoil_chordata.
DR InterPro; IPR017957; P_trefoil_CS.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR13826; PTHR13826; 1.
DR Pfam; PF00088; Trefoil; 1.
DR PRINTS; PR00680; PTREFOIL.
DR SMART; SM00018; PD; 1.
DR SUPFAM; SSF57492; SSF57492; 1.
DR PROSITE; PS00025; P_TREFOIL_1; 1.
DR PROSITE; PS51448; P_TREFOIL_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Disulfide bond; Extracellular matrix; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..80
FT /note="Trefoil factor 3"
FT /id="PRO_0000376811"
FT DOMAIN 30..73
FT /note="P-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 32..58
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 42..57
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 52..69
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 78
FT /note="Interchain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
SQ SEQUENCE 80 AA; 8752 MW; 4DCB9F9123578678 CRC64;
MEARMFWLLV VLLALASSSS AGEYVGLSAN QCAVPAKDRV DCGYPQVTPE QCNNRGCCFD
SSIXGVPWCF KPLQETECTF