ID   TFIIS_ASFM2             Reviewed;         243 AA.
AC   P0C8F6;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Transcription factor TFIIS homolog {ECO:0000250|UniProtKB:P27948};
GN   OrderedLocusNames=Mal-147;
OS   African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=10500;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative initiation factor. Necessary for efficient
CC       transcription elongation past template-encoded arresting sites.
CC       {ECO:0000250|UniProtKB:P07273}.
CC   -!- SIMILARITY: Belongs to the TFS-II family. {ECO:0000305}.
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DR   EMBL; AY261361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0C8F6; -.
DR   Proteomes; UP000000860; Genome.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR035100; TF_IIS-typ.
DR   InterPro; IPR003618; TFIIS_cen_dom.
DR   InterPro; IPR001222; Znf_TFIIS.
DR   Pfam; PF01096; TFIIS_C; 1.
DR   PIRSF; PIRSF006704; TF_IIS; 1.
DR   SMART; SM00510; TFS2M; 1.
DR   SMART; SM00440; ZnF_C2C2; 1.
DR   PROSITE; PS51321; TFIIS_CENTRAL; 1.
DR   PROSITE; PS00466; ZF_TFIIS_1; 1.
DR   PROSITE; PS51133; ZF_TFIIS_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..243
FT                   /note="Transcription factor TFIIS homolog"
FT                   /id="PRO_0000355061"
FT   DOMAIN          77..201
FT                   /note="TFIIS central"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00651"
FT   ZN_FING         202..242
FT                   /note="TFIIS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         206
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         209
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         234
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         237
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
SQ   SEQUENCE   243 AA;  28613 MW;  0CE169C90D2B1F9D CRC64;
     MKMHIARESI VFLLNKHLQN TILTKKIEQE CFLQADTPKK YLQYIKPFLI NCMTKNITTD
     LVMKDSKRLE PYIILEMRDI IQMMFFRTLQ KHIFFKKNTD LCTEYAQKIE ASCYHYTYQQ
     QEKTFLEEYS TRCGTINHII NCEKKSHQQQ DNDALNKLIS GELKPEQLVG MTFAELCPSA
     ALKEKTEITL RSQQKVAEKT SQLYKCPNCK QRMCTYREVQ TRALDEPSTI FCTCKKCGHE
     FIG