ID   TFIP8_BOVIN             Reviewed;         198 AA.
AC   A4IF78;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Tumor necrosis factor alpha-induced protein 8;
DE            Short=TNF alpha-induced protein 8;
GN   Name=TNFAIP8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative mediator of apoptosis. Suppresses the TNF-
CC       mediated apoptosis by inhibiting caspase-8 activity but not the
CC       processing of procaspase-8, subsequently resulting in inhibition of BID
CC       cleavage and caspase-3 activation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TNFAIP8 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC134442; AAI34443.1; -; mRNA.
DR   RefSeq; NP_001077180.1; NM_001083711.2.
DR   AlphaFoldDB; A4IF78; -.
DR   SMR; A4IF78; -.
DR   STRING; 9913.ENSBTAP00000019342; -.
DR   PaxDb; A4IF78; -.
DR   PRIDE; A4IF78; -.
DR   Ensembl; ENSBTAT00000019342; ENSBTAP00000019342; ENSBTAG00000014551.
DR   GeneID; 529336; -.
DR   KEGG; bta:529336; -.
DR   CTD; 25816; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014551; -.
DR   VGNC; VGNC:36157; TNFAIP8.
DR   eggNOG; ENOG502S00N; Eukaryota.
DR   GeneTree; ENSGT00390000003488; -.
DR   HOGENOM; CLU_085918_1_0_1; -.
DR   InParanoid; A4IF78; -.
DR   OMA; FYELEFS; -.
DR   OrthoDB; 1284744at2759; -.
DR   TreeFam; TF323415; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000014551; Expressed in abdominal lymph node and 106 other tissues.
DR   ExpressionAtlas; A4IF78; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IBA:GO_Central.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   Gene3D; 1.20.1440.160; -; 1.
DR   InterPro; IPR008477; TNFAIP8-like.
DR   InterPro; IPR038355; TNFAIP8_sf.
DR   PANTHER; PTHR12757; PTHR12757; 1.
DR   Pfam; PF05527; DUF758; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..198
FT                   /note="Tumor necrosis factor alpha-induced protein 8"
FT                   /id="PRO_0000331428"
FT   COILED          49..83
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   198 AA;  22995 MW;  26D654CE82A6BFB1 CRC64;
     MHFEAEESKE VATDVFNSKN LAVQAQKKIL GKMASKSIAT TLIDDTSSEV LDELYRVTKE
     YTQNKKEAEK IIKNLIKTVI KLAILYRNNQ FNQDELALME KFKKKVHQLA MTVVSFHQVD
     FTFDRNVLSK LLNECREMLH QIIQRHLTTK SHGRVNNVFD HFSDCDFLAA LYNPFGNYKP
     HLQKLCDGIN KMLDEENI