ID   TFIP8_CHICK             Reviewed;         188 AA.
AC   Q5ZI78;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Tumor necrosis factor alpha-induced protein 8;
DE            Short=TNF alpha-induced protein 8;
GN   Name=TNFAIP8; ORFNames=RCJMB04_29h8;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Acts as a negative mediator of apoptosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TNFAIP8 family. {ECO:0000305}.
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DR   EMBL; AJ720906; CAG32565.1; -; mRNA.
DR   RefSeq; NP_001026612.1; NM_001031441.2.
DR   RefSeq; XP_015136098.1; XM_015280612.1.
DR   AlphaFoldDB; Q5ZI78; -.
DR   SMR; Q5ZI78; -.
DR   STRING; 9031.ENSGALP00000041896; -.
DR   PaxDb; Q5ZI78; -.
DR   Ensembl; ENSGALT00000053329; ENSGALP00000053159; ENSGALG00000027761.
DR   Ensembl; ENSGALT00000059398; ENSGALP00000054999; ENSGALG00000027761.
DR   GeneID; 427384; -.
DR   KEGG; gga:427384; -.
DR   CTD; 25816; -.
DR   VEuPathDB; HostDB:geneid_427384; -.
DR   eggNOG; ENOG502S00N; Eukaryota.
DR   GeneTree; ENSGT00390000003488; -.
DR   HOGENOM; CLU_085918_1_0_1; -.
DR   InParanoid; Q5ZI78; -.
DR   PhylomeDB; Q5ZI78; -.
DR   PRO; PR:Q5ZI78; -.
DR   Proteomes; UP000000539; Chromosome Z.
DR   Bgee; ENSGALG00000027761; Expressed in granulocyte and 14 other tissues.
DR   ExpressionAtlas; Q5ZI78; baseline.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ISS:UniProtKB.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR   Gene3D; 1.20.1440.160; -; 1.
DR   InterPro; IPR008477; TNFAIP8-like.
DR   InterPro; IPR038355; TNFAIP8_sf.
DR   PANTHER; PTHR12757; PTHR12757; 1.
DR   Pfam; PF05527; DUF758; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..188
FT                   /note="Tumor necrosis factor alpha-induced protein 8"
FT                   /id="PRO_0000285721"
FT   COILED          39..72
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   188 AA;  21776 MW;  9AA8191FFD95B02A CRC64;
     MATDVFNSKS LAIQAQKKIL GKMVSKSIAT TLIDDTSSDV LDELYRVTKE YTQNKKEAEK
     IIKNLIKIVL KLAILYRNNQ FNQDEIALME KFKKKVHQLA KTVVSFHQVD YTFDRNFLSK
     LLNDCRELLH QIIQRHLTAK SHGRVNNVFD HFSDCEFLAA LYNPFGPYKL HLQKLCDGVN
     RMLDEGNI