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TFIP8_PONAB
ID   TFIP8_PONAB             Reviewed;         198 AA.
AC   Q5RF18;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Tumor necrosis factor alpha-induced protein 8;
DE            Short=TNF alpha-induced protein 8;
GN   Name=TNFAIP8;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative mediator of apoptosis. Suppresses the TNF-
CC       mediated apoptosis by inhibiting caspase-8 activity but not the
CC       processing of procaspase-8, subsequently resulting in inhibition of BID
CC       cleavage and caspase-3 activation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TNFAIP8 family. {ECO:0000305}.
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DR   EMBL; CR857343; CAH89639.1; -; mRNA.
DR   RefSeq; NP_001124734.1; NM_001131262.2.
DR   AlphaFoldDB; Q5RF18; -.
DR   SMR; Q5RF18; -.
DR   STRING; 9601.ENSPPYP00000017570; -.
DR   GeneID; 100171583; -.
DR   KEGG; pon:100171583; -.
DR   CTD; 25816; -.
DR   eggNOG; ENOG502S00N; Eukaryota.
DR   InParanoid; Q5RF18; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ISS:UniProtKB.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR   Gene3D; 1.20.1440.160; -; 1.
DR   InterPro; IPR008477; TNFAIP8-like.
DR   InterPro; IPR038355; TNFAIP8_sf.
DR   PANTHER; PTHR12757; PTHR12757; 1.
DR   Pfam; PF05527; DUF758; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..198
FT                   /note="Tumor necrosis factor alpha-induced protein 8"
FT                   /id="PRO_0000285720"
FT   COILED          49..83
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   198 AA;  23017 MW;  8810EF4CF9AFC088 CRC64;
     MHSEAEESKE VATDVFNSKN LAVQAQKKIL GKMVSKSIAT TLIDDTSSEV LDELYRVTRE
     YTQNKKEAEK IIKNLIKTVI KLAILYRNNQ FNQDELALME KFKKKVHQLA MTVVSFHQVD
     YTFDRNVLSR LLNECREMLH QIIRRHLTAK SHGRVNNVFD HFSDCDFLAA LYNPFGNFKP
     HLQKLCDGIN KMLDEENI
 
 
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