TFIP8_PONAB
ID TFIP8_PONAB Reviewed; 198 AA.
AC Q5RF18;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=Tumor necrosis factor alpha-induced protein 8;
DE Short=TNF alpha-induced protein 8;
GN Name=TNFAIP8;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a negative mediator of apoptosis. Suppresses the TNF-
CC mediated apoptosis by inhibiting caspase-8 activity but not the
CC processing of procaspase-8, subsequently resulting in inhibition of BID
CC cleavage and caspase-3 activation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TNFAIP8 family. {ECO:0000305}.
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DR EMBL; CR857343; CAH89639.1; -; mRNA.
DR RefSeq; NP_001124734.1; NM_001131262.2.
DR AlphaFoldDB; Q5RF18; -.
DR SMR; Q5RF18; -.
DR STRING; 9601.ENSPPYP00000017570; -.
DR GeneID; 100171583; -.
DR KEGG; pon:100171583; -.
DR CTD; 25816; -.
DR eggNOG; ENOG502S00N; Eukaryota.
DR InParanoid; Q5RF18; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ISS:UniProtKB.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR Gene3D; 1.20.1440.160; -; 1.
DR InterPro; IPR008477; TNFAIP8-like.
DR InterPro; IPR038355; TNFAIP8_sf.
DR PANTHER; PTHR12757; PTHR12757; 1.
DR Pfam; PF05527; DUF758; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Coiled coil; Cytoplasm; Reference proteome.
FT CHAIN 1..198
FT /note="Tumor necrosis factor alpha-induced protein 8"
FT /id="PRO_0000285720"
FT COILED 49..83
FT /evidence="ECO:0000255"
SQ SEQUENCE 198 AA; 23017 MW; 8810EF4CF9AFC088 CRC64;
MHSEAEESKE VATDVFNSKN LAVQAQKKIL GKMVSKSIAT TLIDDTSSEV LDELYRVTRE
YTQNKKEAEK IIKNLIKTVI KLAILYRNNQ FNQDELALME KFKKKVHQLA MTVVSFHQVD
YTFDRNVLSR LLNECREMLH QIIRRHLTAK SHGRVNNVFD HFSDCDFLAA LYNPFGNFKP
HLQKLCDGIN KMLDEENI