ID   TFIP8_XENTR             Reviewed;         189 AA.
AC   Q28I19;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Tumor necrosis factor alpha-induced protein 8;
DE            Short=TNF alpha-induced protein 8;
GN   Name=tnfaip8; ORFNames=TEgg053o08.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative mediator of apoptosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TNFAIP8 family. {ECO:0000305}.
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DR   EMBL; CR760636; CAJ81748.1; -; mRNA.
DR   RefSeq; NP_001017184.1; NM_001017184.2.
DR   AlphaFoldDB; Q28I19; -.
DR   SMR; Q28I19; -.
DR   PaxDb; Q28I19; -.
DR   PRIDE; Q28I19; -.
DR   GeneID; 549938; -.
DR   KEGG; xtr:549938; -.
DR   CTD; 25816; -.
DR   Xenbase; XB-GENE-941174; tnfaip8.
DR   eggNOG; ENOG502S00N; Eukaryota.
DR   InParanoid; Q28I19; -.
DR   OrthoDB; 1284744at2759; -.
DR   Reactome; R-XTR-1483255; PI Metabolism.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000017562; Expressed in egg cell and 13 other tissues.
DR   ExpressionAtlas; Q28I19; baseline.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ISS:UniProtKB.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR   Gene3D; 1.20.1440.160; -; 1.
DR   InterPro; IPR008477; TNFAIP8-like.
DR   InterPro; IPR038355; TNFAIP8_sf.
DR   PANTHER; PTHR12757; PTHR12757; 1.
DR   Pfam; PF05527; DUF758; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Reference proteome.
FT   CHAIN           1..189
FT                   /note="Tumor necrosis factor alpha-induced protein 8"
FT                   /id="PRO_0000285723"
SQ   SEQUENCE   189 AA;  21938 MW;  A2CBE145ED4E2BD5 CRC64;
     MATDVFSSKN LAVQAQKKIL GKMASSKYIA TSLIDDTSGE VLDELYQLTR EYTQSKKESE
     KVIKNLIKTV IKLAVLYRNN QFNEEEIALM EKFKRKVHQL AMTVVSFYQV EYTFDRNVLS
     KLLNECRELL HQVIQRHLTA KSHGRVNNVF DHFSNCEFLA ALYNPFGPFK QHLQRLCEGV
     NKMLDEDNI