ID   TFNPH_ASFP4             Reviewed;         706 AA.
AC   P0C9B1;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Termination factor NPH-I homolog {ECO:0000250|UniProtKB:Q89581};
DE            EC=3.6.4.- {ECO:0000250|UniProtKB:Q89581};
GN   OrderedLocusNames=Pret-134;
OS   African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561443;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative DNA-dependent ATPase required for providing the
CC       needed energy to achieve the termination of early transcripts.
CC       {ECO:0000250|UniProtKB:P05807}.
CC   -!- SUBUNIT: Part of the viral DNA-directed RNA polymerase that consists of
CC       8 polII-like subunits (RPB1, RPB2, RPB3, RPB5, RPB6, RPB7, RPB9,
CC       RPB10), a capping enzyme and a termination factor.
CC       {ECO:0000250|UniProtKB:Q89581}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:Q89581}. Note=Found
CC       in association with viral nucleoid. {ECO:0000250|UniProtKB:Q89581}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY261363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000000859; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.10810; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00176; SNF2-rel_dom; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Late protein; Nucleotide-binding;
KW   Transcription; Transcription regulation; Transcription termination; Virion.
FT   CHAIN           1..706
FT                   /note="Termination factor NPH-I homolog"
FT                   /id="PRO_0000373119"
FT   DOMAIN          62..227
FT                   /note="Helicase ATP-binding"
FT   DOMAIN          417..599
FT                   /note="Helicase C-terminal"
FT   MOTIF           168..171
FT                   /note="DEAH box"
FT   BINDING         75..82
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   706 AA;  80309 MW;  AC3B4602B4EE97B3 CRC64;
     MSCVHNNTSF PVQTEAYLKE VFEKYKELQE SKDTSLTARF ARALKYYQFL IYTAFSDPKF
     GIGQGENTRG LLIYHQMGMG KTILSLSLAI SLSHIYNPIL IAPKSLHSNF QQSLLKLIKL
     LYPETTDHSK ELQKISRRFR FVSLDAYNMG QQIIKAGGSL NGCLLIVDEA HNLFRGIINS
     ANDKTNARQL YNNIMQAKNI RILFLTGTPC SKDPFEMVPC FNMLSGRILL PLHYERFYTA
     YVNKTTNSPL NADKLLNRLV GMISYAGNQN ELNKLFPTEL PLIIEKVEMS PEQYRQYLLA
     RDVENAEKHA SSGMYEKINA AALCLPGSEQ ESGSSYYVRS RMISIFASEM LTVKEDEKLS
     EAVQQLPKEA FTENSSPKIV CMLKNIKTSP GPVLIYSQFV ELGLHVVARF LEIEGYQCLQ
     PLKVLEEGHN TILLHKDGKD LMVKNFAEDG PTHTLVLSSK ITRFTLITGK ILSKERDMIQ
     QLWNSPLNIH GEVIKILLVS KTGAEGLDLK YGRQVHILEP YWDKAREDQV KARIIRIGSH
     DALPPEEKTV QPFLYIAVAN QKMFYSIPEG SQEQKTIDER FHERGLEKSH LNSAFRDLLK
     RAAIECAFNG ESGCLMCQPT NALLFHENFE RDLRLPNPCQ PLVKAEVKAY SISYEGKQFF
     YQKNKDVGLG YTFYEYNPII KAYIEIKPSN PLYIKLIKHV QAGTTA