ID   TFP11_CHICK             Reviewed;         827 AA.
AC   Q5ZII9;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Tuftelin-interacting protein 11;
DE   AltName: Full=Septin and tuftelin-interacting protein 1;
DE            Short=STIP-1;
GN   Name=TFIP11; Synonyms=STIP; ORFNames=RCJMB04_25m16;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing, specifically in spliceosome
CC       disassembly during late-stage splicing events. {ECO:0000250}.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFP11/STIP family. {ECO:0000305}.
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DR   EMBL; AJ720795; CAG32454.1; -; mRNA.
DR   RefSeq; NP_001025836.1; NM_001030665.2.
DR   AlphaFoldDB; Q5ZII9; -.
DR   SMR; Q5ZII9; -.
DR   STRING; 9031.ENSGALP00000009008; -.
DR   PaxDb; Q5ZII9; -.
DR   PRIDE; Q5ZII9; -.
DR   Ensembl; ENSGALT00000009022; ENSGALP00000009008; ENSGALG00000005623.
DR   Ensembl; ENSGALT00000072151; ENSGALP00000052803; ENSGALG00000005623.
DR   GeneID; 416909; -.
DR   KEGG; gga:416909; -.
DR   CTD; 24144; -.
DR   VEuPathDB; HostDB:geneid_416909; -.
DR   eggNOG; KOG2184; Eukaryota.
DR   GeneTree; ENSGT00390000012739; -.
DR   HOGENOM; CLU_007977_1_1_1; -.
DR   InParanoid; Q5ZII9; -.
DR   OMA; EFFPKWH; -.
DR   OrthoDB; 1238995at2759; -.
DR   PhylomeDB; Q5ZII9; -.
DR   TreeFam; TF314887; -.
DR   PRO; PR:Q5ZII9; -.
DR   Proteomes; UP000000539; Chromosome 15.
DR   Bgee; ENSGALG00000005623; Expressed in spermatid and 13 other tissues.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IEA:Ensembl.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR   GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
DR   GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0032091; P:negative regulation of protein binding; IEA:Ensembl.
DR   GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IEA:Ensembl.
DR   GO; GO:0000390; P:spliceosomal complex disassembly; IBA:GO_Central.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR022783; GCFC_dom.
DR   InterPro; IPR024933; STIP.
DR   InterPro; IPR022159; STIP/TFIP11_N.
DR   InterPro; IPR045211; TFP11/STIP/Ntr1.
DR   PANTHER; PTHR23329; PTHR23329; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   Pfam; PF07842; GCFC; 1.
DR   Pfam; PF12457; TIP_N; 1.
DR   PIRSF; PIRSF017706; TFIP11; 1.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..827
FT                   /note="Tuftelin-interacting protein 11"
FT                   /id="PRO_0000342279"
FT   DOMAIN          145..191
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          31..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          179..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..65
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   827 AA;  95575 MW;  1C3B51EF98352E8E CRC64;
     MSMSHLYGTD GEDGVEMENF EVSDWDLQNE FNPHRHRHRQ TKEEATYGVW AERDSDEERP
     SFGGKRSRDY SAPVNFISAG LKKSAAEDVS DEDSDEDEKP VKQEEIPKEF VPKKLKTGGN
     FKPSQKGFVG GTKSFMDFGS WERHTKGIGQ KLLQKMGYVP GRGLGKNAQG IINPIEAKQR
     KGKGAVGAYG SERTSQSLQD FPVVDSEEEA EEEFQKELSQ WRKDPNGGKK KPKYSYKTVE
     ELKAKGRINK QLSTPQKELS QVKVIDMTGR EQKVYYSYSQ ISHKHNIPDD NPQQLLGKDS
     KPQGFALPEL EHNLQLLIDI TEQEIIQSDR QLQYERDMVV NLTHEIQKMS EILSHEETAI
     SNLSKVLDMV EECERRMQPS CENPLTLDEC AKIFETLQDK YYEEYRMSDR VDLAVAIVYP
     LMKDYFKNWD PLKDCTYGTE IIAKWKSLLE NDQLLSHGGQ DLSTDAFHRL MWEIWMPYVR
     NIVAQWQPRN CGSMVDFLDS WVHIIPVWIL DNILDQLIFP KLQKEVENWN PLTDTVPIHS
     WIHPWLPLMQ ARLEPLYSPI RNKLANALQK WHPSDSSAKL ILQPWKDVFT PGSWEAFMVK
     NIVPKLGMCL NELIINPHQQ HMDAFYWVID WEGMISVSSL VGLLEKHFFP KWLQVLCSWL
     SNSPNYEEIT KWYLGWKSMF SDQVLAHPSI KDKFNEALDI MNRAVSSSVG GYMQPGAREN
     IAYLTHTERR KDFQYEAMQE RREAENMAQR GIGMAASSVP MNFKDLIQTK AEEHNIVFMP
     VIGKRHEGKQ LYTFGRIVIY IDRGVVFVQG EKTWVPTSLQ SLIDMAK