ID   TFP11_DANRE             Reviewed;         832 AA.
AC   Q6DI35;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Tuftelin-interacting protein 11;
DE   AltName: Full=Septin and tuftelin-interacting protein 1;
DE            Short=STIP-1;
GN   Name=tfip11; Synonyms=stip; ORFNames=zgc:86644;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18307296; DOI=10.1021/pr700667w;
RA   Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA   Slijper M., Heck A.J.R.;
RT   "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT   analysis down to a single embryo.";
RL   J. Proteome Res. 7:1555-1564(2008).
CC   -!- FUNCTION: Involved in pre-mRNA splicing, specifically in spliceosome
CC       disassembly during late-stage splicing events. {ECO:0000250}.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFP11/STIP family. {ECO:0000305}.
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DR   EMBL; BC075755; AAH75755.1; -; mRNA.
DR   EMBL; BC096995; AAH96995.1; -; mRNA.
DR   RefSeq; NP_001002721.1; NM_001002721.1.
DR   AlphaFoldDB; Q6DI35; -.
DR   SMR; Q6DI35; -.
DR   STRING; 7955.ENSDARP00000073961; -.
DR   iPTMnet; Q6DI35; -.
DR   PaxDb; Q6DI35; -.
DR   PRIDE; Q6DI35; -.
DR   GeneID; 436994; -.
DR   KEGG; dre:436994; -.
DR   CTD; 24144; -.
DR   ZFIN; ZDB-GENE-040718-479; tfip11.
DR   eggNOG; KOG2184; Eukaryota.
DR   InParanoid; Q6DI35; -.
DR   OrthoDB; 1238995at2759; -.
DR   PhylomeDB; Q6DI35; -.
DR   PRO; PR:Q6DI35; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
DR   GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000390; P:spliceosomal complex disassembly; IBA:GO_Central.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR022783; GCFC_dom.
DR   InterPro; IPR024933; STIP.
DR   InterPro; IPR022159; STIP/TFIP11_N.
DR   InterPro; IPR045211; TFP11/STIP/Ntr1.
DR   PANTHER; PTHR23329; PTHR23329; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   Pfam; PF07842; GCFC; 1.
DR   Pfam; PF12457; TIP_N; 1.
DR   PIRSF; PIRSF017706; TFIP11; 1.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   1: Evidence at protein level;
KW   mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW   Reference proteome; Spliceosome.
FT   CHAIN           1..832
FT                   /note="Tuftelin-interacting protein 11"
FT                   /id="PRO_0000342280"
FT   DOMAIN          148..194
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          33..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..47
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         209
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18307296"
SQ   SEQUENCE   832 AA;  94577 MW;  74986EF3943C9FE3 CRC64;
     MSMSHLYGRR GDEEEEDGVE IEKFEVSEWD LANEFNPDRR RYRQTKEEAT YGIWAEQDSD
     DERPSFGGKR AKDYSTPVSF VSAGLRKTAA EEKAEREGSD DSDAEEAPPP PRAAAPKKLQ
     TGGSFKTSQR FAGGIRTGQD LGNWEKHTRG IGQKLLQKMG YVPGKGLGKN AQGIVNPIEA
     KLRKGKGAVG AYGSERTQQS LQDFPVVDSE EEEEEEFQKE LGQWRKEPGT AKKKPKYSYR
     TVDDLKAHGT RANMSMSRPA GELAQVKVID MTGREQKVYN SYSHMSQKHS VPEEAPLSVS
     TREQKSSGFA LPELEHNLKL LIELTEQDIL QSARLLQHEK DTVVTLTHES DALQVRLAEE
     EETLGRLEQV MSLVERFEAG DKEGDPALSL QECAKIFEQL QTEFYQEYKT MGLGDLAVSV
     VHPLLKEKLR NWDPLKDCSD GLEEVGQWRA ILESTLSLHS GPDTTNMDPY HRLIWEVWVP
     VMRTCVSQWQ PRNVGPMVDC VECWAPVLPL WILDHVLEQL IFPRLQREVD NWNPLTDTVP
     IHSWIHPWLP LMQTRLEPLY APIRSKLAHA LQRWHPSDSS ARLILQPWRD VFTPGAWEAF
     MVKNIVPKLA LCLGELVVNP HQQLLDPFNW VMDWECMLSV SSMVGLLDKN FFPKWLQVLC
     SWLSNNPNYE EITKWYLGWK GLLSENLLSH PLVKEKLNEA LDIMNRAVAS GLGGYMQPGA
     RENIAYLIQT ERRKDFQCEL QPERREVDNS ATRPPGMAAV PASVPTNFKD LVQAKAEENG
     IVFMPLVAKR HMGKQLFTFG RIVIYIERGV VFVQGEKTWV PTSLQSLIDM AK