TFP11_DICDI
ID TFP11_DICDI Reviewed; 894 AA.
AC A1XDC0; Q556N6; Q86AN4;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Septin and tuftelin-interacting protein 1 homolog;
DE Short=STIP-1;
GN Name=stip-1; Synonyms=stip; ORFNames=DDB_G0272608;
GN and
GN Name=stip-2; Synonyms=stip; ORFNames=DDB_G0274035;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX2;
RX PubMed=17289020; DOI=10.1016/j.yexcr.2007.01.003;
RA Ji Q., Huang C.-H., Peng J., Hashmi S., Ye T., Chen Y.;
RT "Characterization of STIP, a multi-domain nuclear protein, highly conserved
RT in metazoans, and essential for embryogenesis in Caenorhabditis elegans.";
RL Exp. Cell Res. 313:1460-1472(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May be involved in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Identified in the spliceosome C complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TFP11/STIP family. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; DQ342053; ABC69945.1; -; mRNA.
DR EMBL; AAFI02000011; EAL70451.2; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70941.2; -; Genomic_DNA.
DR RefSeq; XP_644376.2; XM_639284.2.
DR RefSeq; XP_645037.2; XM_639945.2.
DR AlphaFoldDB; A1XDC0; -.
DR SMR; A1XDC0; -.
DR STRING; 44689.DDB0233563; -.
DR PaxDb; A1XDC0; -.
DR PRIDE; A1XDC0; -.
DR EnsemblProtists; EAL70451; EAL70451; DDB_G0274035.
DR EnsemblProtists; EAL70941; EAL70941; DDB_G0272608.
DR GeneID; 8618714; -.
DR GeneID; 8619262; -.
DR KEGG; ddi:DDB_G0272608; -.
DR KEGG; ddi:DDB_G0274035; -.
DR dictyBase; DDB_G0272608; stip-1.
DR dictyBase; DDB_G0274035; stip-2.
DR eggNOG; KOG2184; Eukaryota.
DR HOGENOM; CLU_007977_1_0_1; -.
DR InParanoid; A1XDC0; -.
DR OMA; EFFPKWH; -.
DR PhylomeDB; A1XDC0; -.
DR PRO; PR:A1XDC0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
DR GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000390; P:spliceosomal complex disassembly; IBA:GO_Central.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR022783; GCFC_dom.
DR InterPro; IPR022159; STIP/TFIP11_N.
DR InterPro; IPR045211; TFP11/STIP/Ntr1.
DR PANTHER; PTHR23329; PTHR23329; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF07842; GCFC; 1.
DR Pfam; PF12457; TIP_N; 1.
DR SMART; SM00443; G_patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Spliceosome.
FT CHAIN 1..894
FT /note="Septin and tuftelin-interacting protein 1 homolog"
FT /id="PRO_0000342285"
FT DOMAIN 149..195
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT REGION 71..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 329..449
FT /evidence="ECO:0000255"
FT COMPBIAS 74..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..126
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 894 AA; 103525 MW; D31C886EE7C355B6 CRC64;
MNIEGDDEEF YNFNDIKKKR KFTKEDAIYG VFNDGWGDYE DEEESKMTEE EYYKMKKRYS
TPVGFVASGI YEPNEHKLKN KDGENIDNDD DDGEEKKKKK KEKKEKKQKK KEKKEKKEKK
NKKKNKYGGG GGNNYDDSDN DKSIEDKPVG GIGAALLSKM GYKGTGGLGR DGGGMVEPIK
VQVRPKNAGL ASVTELNVNS SDDSDDSDQS EGDTDSDNEN KRSLGWKKKE PKLKYDFDEH
LESTTTTTFK KKTTTTTATT TTSSTPQIVI DMRGPEARLY TGMEEIKHHK HHHHHQHNKE
YQNITSILDD QSKPLSELKH NVDLLLKLKQ IDIQNQDNKI KHENDKINNL TRGVEKLKLT
IENDKEQIKK VTEILETITT VKKQLDQSQL DLKQLYKVFK KLKSNYPKEY QNFKLYNLQK
ELLEPLLKEK LNQWELESNS DNNDNSSLEI SKKLSKEMVK WRQLFQESVS VLGEYQINVY
FLIMRDLFLP KFKNYLRSQW DVKKPSNAAT LISTWSDTLP DVIQEALLEQ SILPKLKVAI
EKWDPRTDPI PLDHWLLPWI PLLGSELESF YPLIRQKIIS ALQDWHPSDK SAIKILTPWK
NIFQSNSMDS LLNRAIIPKL SKSIKDLEIN PSNQKSPIEI QWLLRWSNLN NNDNNNNNNN
NNNNDNNNNN NSITTTDNIN LDSGLITLST IICILEKDFF TRWLKILLEW LKSPDANLEE
ISNWYSGWKK QFPKEIISND KIKSIFNISL NLMKKVLSNE TIQKDDEILI SQKINSLLNT
NINNNNNNNN NINNSYQQQN QQQPIKPISS PSLNSSNNNN IDNISTKQMV EQLAIKNGLL
FIPSEKKTNS GQQIYIFDKI PIIIERDLIM YNNNNNNRWE PANIQYLLDK SLNK
