TFP11_HUMAN
ID TFP11_HUMAN Reviewed; 837 AA.
AC Q9UBB9; O95908; Q20WL0; Q5H8V8; Q9UGV7; Q9Y2Q8;
DT 02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 193.
DE RecName: Full=Tuftelin-interacting protein 11;
DE AltName: Full=Septin and tuftelin-interacting protein 1;
DE Short=STIP-1;
GN Name=TFIP11; Synonyms=STIP; ORFNames=HSPC006;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12529303; DOI=10.1101/gr.695703;
RA Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S.,
RA Bye J.M., Beare D.M., Dunham I.;
RT "Reevaluating human gene annotation: a second-generation analysis of
RT chromosome 22.";
RL Genome Res. 13:27-36(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE SPLICEOSOMAL
RP C COMPLEX.
RX PubMed=11991638; DOI=10.1017/s1355838202021088;
RA Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.;
RT "Purification and characterization of native spliceosomes suitable for
RT three-dimensional structural analysis.";
RL RNA 8:426-439(2002).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [13]
RP FUNCTION IN SPLICEOSOME DISASSEMBLY, IDENTIFICATION IN THE INTRON LARGE
RP COMPLEX, AND INTERACTION WITH DHX15.
RX PubMed=19103666; DOI=10.1093/nar/gkn1002;
RA Yoshimoto R., Kataoka N., Okawa K., Ohno M.;
RT "Isolation and characterization of post-splicing lariat-intron complexes.";
RL Nucleic Acids Res. 37:891-902(2009).
RN [14]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [15]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59; SER-98 AND SER-144, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [16]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [17]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-210, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [18]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59; SER-98 AND SER-210, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [19]
RP INTERACTION WITH GCFC2.
RX PubMed=24304693; DOI=10.1111/gtc.12114;
RA Yoshimoto R., Okawa K., Yoshida M., Ohno M., Kataoka N.;
RT "Identification of a novel component C2ORF3 in the lariat-intron complex:
RT lack of C2ORF3 interferes with pre-mRNA splicing via intron turnover
RT pathway.";
RL Genes Cells 19:78-87(2014).
RN [20]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Involved in pre-mRNA splicing, specifically in spliceosome
CC disassembly during late-stage splicing events. Intron turnover seems to
CC proceed through reactions in two lariat-intron associated complexes
CC termed Intron Large (IL) and Intron Small (IS). In cooperation with
CC DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-
CC containing IL complex to the snRNP-free IS complex leading to efficient
CC debranching and turnover of excised introns. May play a role in the
CC differentiation of ameloblasts and odontoblasts or in the forming of
CC the enamel extracellular matrix. {ECO:0000269|PubMed:19103666}.
CC -!- SUBUNIT: Identified in the spliceosome C complex. Found in the Intron
CC Large (IL) complex, a post-mRNA release spliceosomal complex containing
CC the excised intron, U2, U5 and U6 snRNPs, and splicing factors.
CC Interacts with TUFT1. Interacts with DHX15; indicative for a
CC recruitment of DHX15 to the IL complex. Interacts with GCFC2.
CC {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:19103666,
CC ECO:0000269|PubMed:24304693}.
CC -!- INTERACTION:
CC Q9UBB9; Q4LEZ3: AARD; NbExp=3; IntAct=EBI-1105213, EBI-5463075;
CC Q9UBB9; Q9NYB9: ABI2; NbExp=6; IntAct=EBI-1105213, EBI-743598;
CC Q9UBB9; O94929-2: ABLIM3; NbExp=3; IntAct=EBI-1105213, EBI-11961672;
CC Q9UBB9; Q13155: AIMP2; NbExp=6; IntAct=EBI-1105213, EBI-745226;
CC Q9UBB9; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-1105213, EBI-541426;
CC Q9UBB9; Q9P291: ARMCX1; NbExp=4; IntAct=EBI-1105213, EBI-2843626;
CC Q9UBB9; P48047: ATP5PO; NbExp=3; IntAct=EBI-1105213, EBI-355815;
CC Q9UBB9; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-1105213, EBI-1166928;
CC Q9UBB9; A0A0S2Z4M1: AXIN1; NbExp=3; IntAct=EBI-1105213, EBI-16429430;
CC Q9UBB9; O15169: AXIN1; NbExp=3; IntAct=EBI-1105213, EBI-710484;
CC Q9UBB9; A0A0A0MR97: BAZ2B; NbExp=3; IntAct=EBI-1105213, EBI-11985607;
CC Q9UBB9; Q7RTU4: BHLHA9; NbExp=3; IntAct=EBI-1105213, EBI-17508719;
CC Q9UBB9; Q96LC9: BMF; NbExp=7; IntAct=EBI-1105213, EBI-3919268;
CC Q9UBB9; O95696: BRD1; NbExp=3; IntAct=EBI-1105213, EBI-714754;
CC Q9UBB9; Q13895: BYSL; NbExp=3; IntAct=EBI-1105213, EBI-358049;
CC Q9UBB9; Q9NX04: C1orf109; NbExp=6; IntAct=EBI-1105213, EBI-8643161;
CC Q9UBB9; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-1105213, EBI-739879;
CC Q9UBB9; Q9H257: CARD9; NbExp=3; IntAct=EBI-1105213, EBI-751319;
CC Q9UBB9; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-1105213, EBI-11530605;
CC Q9UBB9; Q969G5: CAVIN3; NbExp=3; IntAct=EBI-1105213, EBI-3893101;
CC Q9UBB9; Q9HC52: CBX8; NbExp=3; IntAct=EBI-1105213, EBI-712912;
CC Q9UBB9; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-1105213, EBI-10171570;
CC Q9UBB9; Q8IYX3: CCDC116; NbExp=3; IntAct=EBI-1105213, EBI-744311;
CC Q9UBB9; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-1105213, EBI-744556;
CC Q9UBB9; Q6ZUS5: CCDC121; NbExp=7; IntAct=EBI-1105213, EBI-2836982;
CC Q9UBB9; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-1105213, EBI-10961312;
CC Q9UBB9; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-1105213, EBI-10749669;
CC Q9UBB9; Q8IYE0-2: CCDC146; NbExp=3; IntAct=EBI-1105213, EBI-10247802;
CC Q9UBB9; A0A1B0GWI1: CCDC196; NbExp=3; IntAct=EBI-1105213, EBI-10181422;
CC Q9UBB9; Q96M95: CCDC42; NbExp=5; IntAct=EBI-1105213, EBI-747041;
CC Q9UBB9; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-1105213, EBI-10961624;
CC Q9UBB9; Q16204: CCDC6; NbExp=3; IntAct=EBI-1105213, EBI-1045350;
CC Q9UBB9; Q9H2F9: CCDC68; NbExp=8; IntAct=EBI-1105213, EBI-2813327;
CC Q9UBB9; Q2M329: CCDC96; NbExp=4; IntAct=EBI-1105213, EBI-12382974;
CC Q9UBB9; Q8TD31-3: CCHCR1; NbExp=8; IntAct=EBI-1105213, EBI-10175300;
CC Q9UBB9; P30281: CCND3; NbExp=5; IntAct=EBI-1105213, EBI-375013;
CC Q9UBB9; P51959: CCNG1; NbExp=3; IntAct=EBI-1105213, EBI-3905829;
CC Q9UBB9; Q9UK58: CCNL1; NbExp=3; IntAct=EBI-1105213, EBI-2836773;
CC Q9UBB9; P38936: CDKN1A; NbExp=3; IntAct=EBI-1105213, EBI-375077;
CC Q9UBB9; Q86X02: CDR2L; NbExp=3; IntAct=EBI-1105213, EBI-11063830;
CC Q9UBB9; Q71F23: CENPU; NbExp=4; IntAct=EBI-1105213, EBI-2515234;
CC Q9UBB9; Q86XR8: CEP57; NbExp=4; IntAct=EBI-1105213, EBI-308614;
CC Q9UBB9; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-1105213, EBI-11752486;
CC Q9UBB9; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-1105213, EBI-1104570;
CC Q9UBB9; Q96GE4: CEP95; NbExp=3; IntAct=EBI-1105213, EBI-372775;
CC Q9UBB9; Q8IYR0: CFAP206; NbExp=4; IntAct=EBI-1105213, EBI-749051;
CC Q9UBB9; Q8NI60: COQ8A; NbExp=13; IntAct=EBI-1105213, EBI-745535;
CC Q9UBB9; P10606: COX5B; NbExp=5; IntAct=EBI-1105213, EBI-1053725;
CC Q9UBB9; Q8WUE5: CT55; NbExp=3; IntAct=EBI-1105213, EBI-6873363;
CC Q9UBB9; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-1105213, EBI-5453285;
CC Q9UBB9; Q9UER7: DAXX; NbExp=3; IntAct=EBI-1105213, EBI-77321;
CC Q9UBB9; Q9UHL0: DDX25; NbExp=3; IntAct=EBI-1105213, EBI-8787165;
CC Q9UBB9; P17661: DES; NbExp=3; IntAct=EBI-1105213, EBI-1055572;
CC Q9UBB9; Q9NRI5: DISC1; NbExp=3; IntAct=EBI-1105213, EBI-529989;
CC Q9UBB9; Q6W0C5: DPPA3; NbExp=3; IntAct=EBI-1105213, EBI-12082590;
CC Q9UBB9; O60941-5: DTNB; NbExp=3; IntAct=EBI-1105213, EBI-11984733;
CC Q9UBB9; O15371: EIF3D; NbExp=3; IntAct=EBI-1105213, EBI-353818;
CC Q9UBB9; Q7L775: EPM2AIP1; NbExp=3; IntAct=EBI-1105213, EBI-6255981;
CC Q9UBB9; Q86VI1: EXOC3L1; NbExp=3; IntAct=EBI-1105213, EBI-2813180;
CC Q9UBB9; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-1105213, EBI-742102;
CC Q9UBB9; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-1105213, EBI-371876;
CC Q9UBB9; Q8NE31: FAM13C; NbExp=5; IntAct=EBI-1105213, EBI-751248;
CC Q9UBB9; Q8NDB6: FAM156A; NbExp=3; IntAct=EBI-1105213, EBI-749727;
CC Q9UBB9; Q3B820: FAM161A; NbExp=9; IntAct=EBI-1105213, EBI-719941;
CC Q9UBB9; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-1105213, EBI-7225287;
CC Q9UBB9; Q9Y247: FAM50B; NbExp=3; IntAct=EBI-1105213, EBI-742802;
CC Q9UBB9; Q8TBF8: FAM81A; NbExp=3; IntAct=EBI-1105213, EBI-11993062;
CC Q9UBB9; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-1105213, EBI-6658203;
CC Q9UBB9; P02671-2: FGA; NbExp=3; IntAct=EBI-1105213, EBI-9640259;
CC Q9UBB9; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-1105213, EBI-372506;
CC Q9UBB9; Q8NHY3: GAS2L2; NbExp=3; IntAct=EBI-1105213, EBI-7960826;
CC Q9UBB9; Q96CN9: GCC1; NbExp=3; IntAct=EBI-1105213, EBI-746252;
CC Q9UBB9; P16383: GCFC2; NbExp=5; IntAct=EBI-1105213, EBI-954074;
CC Q9UBB9; P55040: GEM; NbExp=7; IntAct=EBI-1105213, EBI-744104;
CC Q9UBB9; P14136: GFAP; NbExp=3; IntAct=EBI-1105213, EBI-744302;
CC Q9UBB9; B1APZ0: GNG4; NbExp=3; IntAct=EBI-1105213, EBI-10175453;
CC Q9UBB9; Q92805: GOLGA1; NbExp=6; IntAct=EBI-1105213, EBI-6164177;
CC Q9UBB9; Q13227: GPS2; NbExp=6; IntAct=EBI-1105213, EBI-713355;
CC Q9UBB9; Q14687: GSE1; NbExp=3; IntAct=EBI-1105213, EBI-372619;
CC Q9UBB9; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-1105213, EBI-2514791;
CC Q9UBB9; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-1105213, EBI-14103818;
CC Q9UBB9; P56524-2: HDAC4; NbExp=3; IntAct=EBI-1105213, EBI-11953488;
CC Q9UBB9; O75146-2: HIP1R; NbExp=3; IntAct=EBI-1105213, EBI-12292427;
CC Q9UBB9; Q9P0W2: HMG20B; NbExp=3; IntAct=EBI-1105213, EBI-713401;
CC Q9UBB9; Q9UJC3: HOOK1; NbExp=8; IntAct=EBI-1105213, EBI-746704;
CC Q9UBB9; O75031: HSF2BP; NbExp=3; IntAct=EBI-1105213, EBI-7116203;
CC Q9UBB9; Q70UQ0: IKBIP; NbExp=3; IntAct=EBI-1105213, EBI-2557212;
CC Q9UBB9; Q14005-2: IL16; NbExp=3; IntAct=EBI-1105213, EBI-17178971;
CC Q9UBB9; Q9NV31: IMP3; NbExp=4; IntAct=EBI-1105213, EBI-747481;
CC Q9UBB9; O75564-2: JRK; NbExp=3; IntAct=EBI-1105213, EBI-17181882;
CC Q9UBB9; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-1105213, EBI-2556193;
CC Q9UBB9; Q7Z3B3: KANSL1; NbExp=5; IntAct=EBI-1105213, EBI-740244;
CC Q9UBB9; Q92993: KAT5; NbExp=3; IntAct=EBI-1105213, EBI-399080;
CC Q9UBB9; O60341: KDM1A; NbExp=3; IntAct=EBI-1105213, EBI-710124;
CC Q9UBB9; O14782: KIF3C; NbExp=3; IntAct=EBI-1105213, EBI-1104854;
CC Q9UBB9; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-1105213, EBI-8472129;
CC Q9UBB9; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-1105213, EBI-14069005;
CC Q9UBB9; Q2M2Z5: KIZ; NbExp=3; IntAct=EBI-1105213, EBI-2554344;
CC Q9UBB9; P04264: KRT1; NbExp=3; IntAct=EBI-1105213, EBI-298429;
CC Q9UBB9; P35900: KRT20; NbExp=7; IntAct=EBI-1105213, EBI-742094;
CC Q9UBB9; P02538: KRT6A; NbExp=10; IntAct=EBI-1105213, EBI-702198;
CC Q9UBB9; P04259: KRT6B; NbExp=6; IntAct=EBI-1105213, EBI-740907;
CC Q9UBB9; P48668: KRT6C; NbExp=3; IntAct=EBI-1105213, EBI-2564105;
CC Q9UBB9; P05787: KRT8; NbExp=3; IntAct=EBI-1105213, EBI-297852;
CC Q9UBB9; Q6PJG3: LATS1; NbExp=3; IntAct=EBI-1105213, EBI-10253976;
CC Q9UBB9; Q86VQ0: LCA5; NbExp=4; IntAct=EBI-1105213, EBI-6658186;
CC Q9UBB9; O95447: LCA5L; NbExp=6; IntAct=EBI-1105213, EBI-8473670;
CC Q9UBB9; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-1105213, EBI-726510;
CC Q9UBB9; Q96GY3: LIN37; NbExp=3; IntAct=EBI-1105213, EBI-748884;
CC Q9UBB9; Q03252: LMNB2; NbExp=3; IntAct=EBI-1105213, EBI-2830427;
CC Q9UBB9; P25800: LMO1; NbExp=7; IntAct=EBI-1105213, EBI-8639312;
CC Q9UBB9; P25791-3: LMO2; NbExp=3; IntAct=EBI-1105213, EBI-11959475;
CC Q9UBB9; P61968: LMO4; NbExp=6; IntAct=EBI-1105213, EBI-2798728;
CC Q9UBB9; Q0VAF8: LOC729862; NbExp=3; IntAct=EBI-1105213, EBI-10226726;
CC Q9UBB9; Q0VAF9: LOC729862; NbExp=3; IntAct=EBI-1105213, EBI-10226748;
CC Q9UBB9; Q96S90: LYSMD1; NbExp=3; IntAct=EBI-1105213, EBI-10293291;
CC Q9UBB9; Q9Y586: MAB21L2; NbExp=3; IntAct=EBI-1105213, EBI-6659161;
CC Q9UBB9; Q9H7H0: METTL17; NbExp=5; IntAct=EBI-1105213, EBI-749353;
CC Q9UBB9; P55081: MFAP1; NbExp=3; IntAct=EBI-1105213, EBI-1048159;
CC Q9UBB9; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-1105213, EBI-14086479;
CC Q9UBB9; Q13064: MKRN3; NbExp=3; IntAct=EBI-1105213, EBI-2340269;
CC Q9UBB9; Q9Y3B7: MRPL11; NbExp=3; IntAct=EBI-1105213, EBI-5453723;
CC Q9UBB9; Q6P444: MTFR2; NbExp=3; IntAct=EBI-1105213, EBI-10252703;
CC Q9UBB9; Q9BW11: MXD3; NbExp=3; IntAct=EBI-1105213, EBI-741574;
CC Q9UBB9; P52179-2: MYOM1; NbExp=3; IntAct=EBI-1105213, EBI-12010196;
CC Q9UBB9; O14777: NDC80; NbExp=6; IntAct=EBI-1105213, EBI-715849;
CC Q9UBB9; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-1105213, EBI-11750983;
CC Q9UBB9; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-1105213, EBI-10271199;
CC Q9UBB9; Q9UMS0: NFU1; NbExp=6; IntAct=EBI-1105213, EBI-725252;
CC Q9UBB9; Q6X4W1-2: NSMF; NbExp=3; IntAct=EBI-1105213, EBI-12028784;
CC Q9UBB9; Q99567: NUP88; NbExp=3; IntAct=EBI-1105213, EBI-726178;
CC Q9UBB9; A5D8V7: ODAD3; NbExp=6; IntAct=EBI-1105213, EBI-8466445;
CC Q9UBB9; A5D8V7-2: ODAD3; NbExp=3; IntAct=EBI-1105213, EBI-10173824;
CC Q9UBB9; O43482: OIP5; NbExp=6; IntAct=EBI-1105213, EBI-536879;
CC Q9UBB9; Q96AL5: PBX3; NbExp=3; IntAct=EBI-1105213, EBI-741171;
CC Q9UBB9; Q9BYU1: PBX4; NbExp=9; IntAct=EBI-1105213, EBI-10302990;
CC Q9UBB9; Q8TBR0: PDE4DIP; NbExp=3; IntAct=EBI-1105213, EBI-10240575;
CC Q9UBB9; O43189: PHF1; NbExp=3; IntAct=EBI-1105213, EBI-530034;
CC Q9UBB9; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-1105213, EBI-14066006;
CC Q9UBB9; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-1105213, EBI-79165;
CC Q9UBB9; Q6P5Z2: PKN3; NbExp=3; IntAct=EBI-1105213, EBI-1384335;
CC Q9UBB9; O00444: PLK4; NbExp=3; IntAct=EBI-1105213, EBI-746202;
CC Q9UBB9; Q9UGP5-2: POLL; NbExp=3; IntAct=EBI-1105213, EBI-10320765;
CC Q9UBB9; O15160: POLR1C; NbExp=5; IntAct=EBI-1105213, EBI-1055079;
CC Q9UBB9; Q96HA1-2: POM121; NbExp=3; IntAct=EBI-1105213, EBI-11956563;
CC Q9UBB9; O75145: PPFIA3; NbExp=3; IntAct=EBI-1105213, EBI-1763225;
CC Q9UBB9; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-1105213, EBI-2557469;
CC Q9UBB9; Q8WWY3: PRPF31; NbExp=12; IntAct=EBI-1105213, EBI-1567797;
CC Q9UBB9; P25789: PSMA4; NbExp=3; IntAct=EBI-1105213, EBI-359310;
CC Q9UBB9; P62195: PSMC5; NbExp=3; IntAct=EBI-1105213, EBI-357745;
CC Q9UBB9; A0A0S2Z528: PSTPIP1; NbExp=3; IntAct=EBI-1105213, EBI-16430249;
CC Q9UBB9; O75127: PTCD1; NbExp=3; IntAct=EBI-1105213, EBI-2560233;
CC Q9UBB9; Q9P2K3: RCOR3; NbExp=3; IntAct=EBI-1105213, EBI-743428;
CC Q9UBB9; Q9BSD3: RHNO1; NbExp=6; IntAct=EBI-1105213, EBI-9658624;
CC Q9UBB9; Q13671: RIN1; NbExp=3; IntAct=EBI-1105213, EBI-366017;
CC Q9UBB9; A0A0S2Z4G9: RNF6; NbExp=3; IntAct=EBI-1105213, EBI-16428950;
CC Q9UBB9; Q9Y3A4: RRP7A; NbExp=5; IntAct=EBI-1105213, EBI-7223720;
CC Q9UBB9; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-1105213, EBI-11984663;
CC Q9UBB9; P28702-3: RXRB; NbExp=3; IntAct=EBI-1105213, EBI-16429492;
CC Q9UBB9; P25815: S100P; NbExp=3; IntAct=EBI-1105213, EBI-743700;
CC Q9UBB9; Q9UHR5: SAP30BP; NbExp=4; IntAct=EBI-1105213, EBI-751683;
CC Q9UBB9; Q9BWG6: SCNM1; NbExp=5; IntAct=EBI-1105213, EBI-748391;
CC Q9UBB9; Q86XK3: SFR1; NbExp=4; IntAct=EBI-1105213, EBI-1104535;
CC Q9UBB9; Q96ES7: SGF29; NbExp=3; IntAct=EBI-1105213, EBI-743117;
CC Q9UBB9; Q9H788: SH2D4A; NbExp=8; IntAct=EBI-1105213, EBI-747035;
CC Q9UBB9; Q9H788-2: SH2D4A; NbExp=3; IntAct=EBI-1105213, EBI-10308083;
CC Q9UBB9; Q9Y371: SH3GLB1; NbExp=7; IntAct=EBI-1105213, EBI-2623095;
CC Q9UBB9; Q969G3: SMARCE1; NbExp=7; IntAct=EBI-1105213, EBI-455078;
CC Q9UBB9; O95295: SNAPIN; NbExp=3; IntAct=EBI-1105213, EBI-296723;
CC Q9UBB9; P14678-2: SNRPB; NbExp=6; IntAct=EBI-1105213, EBI-372475;
CC Q9UBB9; Q13573: SNW1; NbExp=7; IntAct=EBI-1105213, EBI-632715;
CC Q9UBB9; Q7Z614: SNX20; NbExp=4; IntAct=EBI-1105213, EBI-744896;
CC Q9UBB9; Q86XE0: SNX32; NbExp=3; IntAct=EBI-1105213, EBI-8099743;
CC Q9UBB9; O94964-4: SOGA1; NbExp=3; IntAct=EBI-1105213, EBI-14083835;
CC Q9UBB9; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-1105213, EBI-742688;
CC Q9UBB9; Q9Y2D8: SSX2IP; NbExp=4; IntAct=EBI-1105213, EBI-2212028;
CC Q9UBB9; Q7Z7C7: STRA8; NbExp=3; IntAct=EBI-1105213, EBI-12036261;
CC Q9UBB9; O43815: STRN; NbExp=3; IntAct=EBI-1105213, EBI-1046642;
CC Q9UBB9; Q9Y2I9-2: TBC1D30; NbExp=3; IntAct=EBI-1105213, EBI-17455779;
CC Q9UBB9; Q969Z0: TBRG4; NbExp=3; IntAct=EBI-1105213, EBI-702328;
CC Q9UBB9; Q9Y4C2: TCAF1; NbExp=3; IntAct=EBI-1105213, EBI-750484;
CC Q9UBB9; Q9Y4C2-2: TCAF1; NbExp=3; IntAct=EBI-1105213, EBI-11974855;
CC Q9UBB9; A0A024R4Q5: TFPT; NbExp=4; IntAct=EBI-1105213, EBI-11527449;
CC Q9UBB9; P0C1Z6-2: TFPT; NbExp=3; IntAct=EBI-1105213, EBI-10178002;
CC Q9UBB9; Q9BT49: THAP7; NbExp=7; IntAct=EBI-1105213, EBI-741350;
CC Q9UBB9; Q8NA92: THAP8; NbExp=5; IntAct=EBI-1105213, EBI-717429;
CC Q9UBB9; P13805: TNNT1; NbExp=4; IntAct=EBI-1105213, EBI-726527;
CC Q9UBB9; Q9Y228: TRAF3IP3; NbExp=4; IntAct=EBI-1105213, EBI-765817;
CC Q9UBB9; Q9H8W5-2: TRIM45; NbExp=3; IntAct=EBI-1105213, EBI-11993364;
CC Q9UBB9; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-1105213, EBI-11059915;
CC Q9UBB9; Q99816: TSG101; NbExp=3; IntAct=EBI-1105213, EBI-346882;
CC Q9UBB9; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-1105213, EBI-10241197;
CC Q9UBB9; Q9NRE2: TSHZ2; NbExp=3; IntAct=EBI-1105213, EBI-10687282;
CC Q9UBB9; Q63HK5: TSHZ3; NbExp=7; IntAct=EBI-1105213, EBI-9053916;
CC Q9UBB9; Q9UJ04: TSPYL4; NbExp=3; IntAct=EBI-1105213, EBI-308511;
CC Q9UBB9; P40222: TXLNA; NbExp=8; IntAct=EBI-1105213, EBI-359793;
CC Q9UBB9; Q99757: TXN2; NbExp=3; IntAct=EBI-1105213, EBI-2932492;
CC Q9UBB9; P0CB47: UBTFL1; NbExp=3; IntAct=EBI-1105213, EBI-17208936;
CC Q9UBB9; O75604: USP2; NbExp=3; IntAct=EBI-1105213, EBI-743272;
CC Q9UBB9; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-1105213, EBI-2559305;
CC Q9UBB9; Q96JC1-2: VPS39; NbExp=3; IntAct=EBI-1105213, EBI-11962886;
CC Q9UBB9; Q9Y3C0: WASHC3; NbExp=3; IntAct=EBI-1105213, EBI-712969;
CC Q9UBB9; Q53FD0: ZC2HC1C; NbExp=4; IntAct=EBI-1105213, EBI-740767;
CC Q9UBB9; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-1105213, EBI-8656416;
CC Q9UBB9; A0A0S2Z6H0: ZGPAT; NbExp=3; IntAct=EBI-1105213, EBI-16428984;
CC Q9UBB9; Q8N5A5: ZGPAT; NbExp=5; IntAct=EBI-1105213, EBI-3439227;
CC Q9UBB9; Q8N5A5-2: ZGPAT; NbExp=9; IntAct=EBI-1105213, EBI-10183064;
CC Q9UBB9; Q96NC0: ZMAT2; NbExp=4; IntAct=EBI-1105213, EBI-2682299;
CC Q9UBB9; Q8TAU3: ZNF417; NbExp=4; IntAct=EBI-1105213, EBI-740727;
CC Q9UBB9; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-1105213, EBI-10172590;
CC Q9UBB9; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-1105213, EBI-6427977;
CC Q9UBB9; Q9ULD5: ZNF777; NbExp=3; IntAct=EBI-1105213, EBI-11975599;
CC Q9UBB9; O43309: ZSCAN12; NbExp=3; IntAct=EBI-1105213, EBI-1210440;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=In the nucleus localizes to unique speckle domains in close
CC proximity to nuclear speckles and not identical to paraspeckles.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UBB9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UBB9-2; Sequence=VSP_003998, VSP_003999;
CC -!- SIMILARITY: Belongs to the TFP11/STIP family. {ECO:0000305}.
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DR EMBL; AF070662; AAD20968.1; -; mRNA.
DR EMBL; AL080147; CAB45740.1; -; mRNA.
DR EMBL; AL050258; CAB43360.1; -; mRNA.
DR EMBL; BT007274; AAP35938.1; -; mRNA.
DR EMBL; CT841511; CAJ86441.1; -; mRNA.
DR EMBL; Z95115; CAI17979.1; -; Genomic_DNA.
DR EMBL; Z99714; CAI17979.1; JOINED; Genomic_DNA.
DR EMBL; Z99714; CAI17878.1; -; Genomic_DNA.
DR EMBL; Z95115; CAI17878.1; JOINED; Genomic_DNA.
DR EMBL; CH471095; EAW59723.1; -; Genomic_DNA.
DR EMBL; BC011599; AAH11599.1; -; mRNA.
DR CCDS; CCDS13838.1; -. [Q9UBB9-1]
DR PIR; T12531; T12531.
DR RefSeq; NP_001008697.1; NM_001008697.2. [Q9UBB9-1]
DR RefSeq; NP_001333786.1; NM_001346857.1. [Q9UBB9-1]
DR RefSeq; NP_001333787.1; NM_001346858.1. [Q9UBB9-1]
DR RefSeq; NP_001333788.1; NM_001346859.1. [Q9UBB9-1]
DR RefSeq; NP_001333790.1; NM_001346861.1. [Q9UBB9-1]
DR RefSeq; NP_036275.1; NM_012143.3. [Q9UBB9-1]
DR RefSeq; XP_011528381.1; XM_011530079.1.
DR RefSeq; XP_016884224.1; XM_017028735.1.
DR AlphaFoldDB; Q9UBB9; -.
DR SMR; Q9UBB9; -.
DR BioGRID; 117294; 385.
DR CORUM; Q9UBB9; -.
DR IntAct; Q9UBB9; 275.
DR MINT; Q9UBB9; -.
DR STRING; 9606.ENSP00000384421; -.
DR GlyGen; Q9UBB9; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9UBB9; -.
DR MetOSite; Q9UBB9; -.
DR PhosphoSitePlus; Q9UBB9; -.
DR BioMuta; TFIP11; -.
DR DMDM; 22096235; -.
DR EPD; Q9UBB9; -.
DR jPOST; Q9UBB9; -.
DR MassIVE; Q9UBB9; -.
DR MaxQB; Q9UBB9; -.
DR PaxDb; Q9UBB9; -.
DR PeptideAtlas; Q9UBB9; -.
DR PRIDE; Q9UBB9; -.
DR ProteomicsDB; 83928; -. [Q9UBB9-1]
DR ProteomicsDB; 83929; -. [Q9UBB9-2]
DR Antibodypedia; 9983; 132 antibodies from 22 providers.
DR DNASU; 24144; -.
DR Ensembl; ENST00000405938.5; ENSP00000384297.1; ENSG00000100109.17. [Q9UBB9-1]
DR Ensembl; ENST00000407148.5; ENSP00000385861.1; ENSG00000100109.17. [Q9UBB9-1]
DR Ensembl; ENST00000407431.5; ENSP00000383892.1; ENSG00000100109.17. [Q9UBB9-1]
DR Ensembl; ENST00000407690.6; ENSP00000384421.1; ENSG00000100109.17. [Q9UBB9-1]
DR Ensembl; ENST00000619735.4; ENSP00000480171.1; ENSG00000100109.17. [Q9UBB9-1]
DR GeneID; 24144; -.
DR KEGG; hsa:24144; -.
DR MANE-Select; ENST00000407690.6; ENSP00000384421.1; NM_012143.4; NP_036275.1.
DR UCSC; uc003acr.4; human. [Q9UBB9-1]
DR CTD; 24144; -.
DR DisGeNET; 24144; -.
DR GeneCards; TFIP11; -.
DR HGNC; HGNC:17165; TFIP11.
DR HPA; ENSG00000100109; Low tissue specificity.
DR MIM; 612747; gene.
DR neXtProt; NX_Q9UBB9; -.
DR OpenTargets; ENSG00000100109; -.
DR PharmGKB; PA38441; -.
DR VEuPathDB; HostDB:ENSG00000100109; -.
DR eggNOG; KOG2184; Eukaryota.
DR GeneTree; ENSGT00390000012739; -.
DR HOGENOM; CLU_007977_1_1_1; -.
DR InParanoid; Q9UBB9; -.
DR OMA; EFFPKWH; -.
DR PhylomeDB; Q9UBB9; -.
DR TreeFam; TF314887; -.
DR PathwayCommons; Q9UBB9; -.
DR Reactome; R-HSA-72163; mRNA Splicing - Major Pathway.
DR SignaLink; Q9UBB9; -.
DR BioGRID-ORCS; 24144; 684 hits in 1080 CRISPR screens.
DR ChiTaRS; TFIP11; human.
DR GeneWiki; TFIP11; -.
DR GenomeRNAi; 24144; -.
DR Pharos; Q9UBB9; Tbio.
DR PRO; PR:Q9UBB9; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9UBB9; protein.
DR Bgee; ENSG00000100109; Expressed in granulocyte and 182 other tissues.
DR ExpressionAtlas; Q9UBB9; baseline and differential.
DR Genevisible; Q9UBB9; HS.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
DR GO; GO:0000781; C:chromosome, telomeric region; IDA:BHF-UCL.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IDA:LIFEdb.
DR GO; GO:0005730; C:nucleolus; IDA:BHF-UCL.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005681; C:spliceosomal complex; IDA:UniProtKB.
DR GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IDA:UniProtKB.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB.
DR GO; GO:1904876; P:negative regulation of DNA ligase activity; IC:BHF-UCL.
DR GO; GO:2001033; P:negative regulation of double-strand break repair via nonhomologous end joining; ISS:BHF-UCL.
DR GO; GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
DR GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IDA:BHF-UCL.
DR GO; GO:0031848; P:protection from non-homologous end joining at telomere; IC:BHF-UCL.
DR GO; GO:0006396; P:RNA processing; IC:UniProtKB.
DR GO; GO:0000390; P:spliceosomal complex disassembly; IMP:UniProtKB.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR022783; GCFC_dom.
DR InterPro; IPR024933; STIP.
DR InterPro; IPR022159; STIP/TFIP11_N.
DR InterPro; IPR045211; TFP11/STIP/Ntr1.
DR PANTHER; PTHR23329; PTHR23329; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF07842; GCFC; 1.
DR Pfam; PF12457; TIP_N; 1.
DR PIRSF; PIRSF017706; TFIP11; 1.
DR SMART; SM00443; G_patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Biomineralization; Cytoplasm; mRNA processing;
KW mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome.
FT CHAIN 1..837
FT /note="Tuftelin-interacting protein 11"
FT /id="PRO_0000072501"
FT DOMAIN 149..195
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT REGION 1..50
FT /note="Required for interaction with DHX15"
FT /evidence="ECO:0000269|PubMed:19103666"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..734
FT /note="Required for nuclear speckle localization"
FT /evidence="ECO:0000250"
FT MOTIF 700..705
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 53..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5U2Y6"
FT MOD_RES 59
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 98
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17081983,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 144
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 210
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..641
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11042152"
FT /id="VSP_003998"
FT VAR_SEQ 642..663
FT /note="EGMISVSSLVGLLEKHFFPKWL -> MATSEILPSFVATMDASNFSFW (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:11042152"
FT /id="VSP_003999"
FT VARIANT 177
FT /note="N -> S (in dbSNP:rs6005062)"
FT /id="VAR_054069"
SQ SEQUENCE 837 AA; 96820 MW; F4C44F8411517289 CRC64;
MSLSHLYRDG EGRIDDDDDE RENFEITDWD LQNEFNPNRQ RHWQTKEEAT YGVWAERDSD
DERPSFGGKR ARDYSAPVNF ISAGLKKGAA EEAELEDSDD EEKPVKQDDF PKDFGPRKLK
TGGNFKPSQK GFAGGTKSFM DFGSWERHTK GIGQKLLQKM GYVPGRGLGK NAQGIINPIE
AKQRKGKGAV GAYGSERTTQ SMQDFPVVDS EEEAEEEFQK ELSQWRKDPS GSKKKPKYSY
KTVEELKAKG RISKKLTAPQ KELSQVKVID MTGREQKVYY SYSQISHKHN VPDDGLPLQS
QQLPQSGKEA KAPGFALPEL EHNLQLLIDL TEQEIIQNDR QLQYERDMVV NLFHELEKMT
EVLDHEERVI SNLSKVLEMV EECERRMQPD CSNPLTLDEC ARIFETLQDK YYEEYRMSDR
VDLAVAIVYP LMKEYFKEWD PLKDCTYGTE IISKWKSLLE NDQLLSHGGQ DLSADAFHRL
IWEVWMPFVR NIVTQWQPRN CDPMVDFLDS WVHIIPVWIL DNILDQLIFP KLQKEVENWN
PLTDTVPIHS WIHPWLPLMQ ARLEPLYSPI RSKLSSALQK WHPSDSSAKL ILQPWKDVFT
PGSWEAFMVK NIVPKLGMCL GELVINPHQQ HMDAFYWVID WEGMISVSSL VGLLEKHFFP
KWLQVLCSWL SNSPNYEEIT KWYLGWKSMF SDQVLAHPSV KDKFNEALDI MNRAVSSNVG
AYMQPGAREN IAYLTHTERR KDFQYEAMQE RREAENMAQR GIGVAASSVP MNFKDLIETK
AEEHNIVFMP VIGKRHEGKQ LYTFGRIVIY IDRGVVFVQG EKTWVPTSLQ SLIDMAK
