ID   TFP11_XENLA             Reviewed;         824 AA.
AC   Q66J74;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Tuftelin-interacting protein 11;
DE   AltName: Full=Septin and tuftelin-interacting protein 1;
DE            Short=STIP-1;
GN   Name=tfip11; Synonyms=stip;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=17289020; DOI=10.1016/j.yexcr.2007.01.003;
RA   Ji Q., Huang C.-H., Peng J., Hashmi S., Ye T., Chen Y.;
RT   "Characterization of STIP, a multi-domain nuclear protein, highly conserved
RT   in metazoans, and essential for embryogenesis in Caenorhabditis elegans.";
RL   Exp. Cell Res. 313:1460-1472(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing, specifically in spliceosome
CC       disassembly during late-stage splicing events. {ECO:0000250}.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFP11/STIP family. {ECO:0000305}.
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DR   EMBL; DQ342033; ABC69925.1; -; mRNA.
DR   EMBL; BC081033; AAH81033.1; -; mRNA.
DR   RefSeq; NP_001087642.1; NM_001094173.1.
DR   AlphaFoldDB; Q66J74; -.
DR   SMR; Q66J74; -.
DR   DNASU; 447466; -.
DR   GeneID; 447466; -.
DR   KEGG; xla:447466; -.
DR   CTD; 447466; -.
DR   Xenbase; XB-GENE-984527; tfip11.L.
DR   OrthoDB; 1238995at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 447466; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000390; P:spliceosomal complex disassembly; IEA:InterPro.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR022783; GCFC_dom.
DR   InterPro; IPR024933; STIP.
DR   InterPro; IPR022159; STIP/TFIP11_N.
DR   InterPro; IPR045211; TFP11/STIP/Ntr1.
DR   PANTHER; PTHR23329; PTHR23329; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   Pfam; PF07842; GCFC; 1.
DR   Pfam; PF12457; TIP_N; 1.
DR   PIRSF; PIRSF017706; TFIP11; 1.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..824
FT                   /note="Tuftelin-interacting protein 11"
FT                   /id="PRO_0000342281"
FT   DOMAIN          145..191
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          1..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..66
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   824 AA;  95245 MW;  85B6B494770FFD8A CRC64;
     MSMSHLYGKD EDSDGVEMEN FEITDWDLQN EFNPNRRKHF QTKEEATYGM WAEHDSDDER
     PSFGGKRSRD YSAPVNFISA GIRKPAAEEK SDSDSDSETQ SRRENFPKDF EAKKLRTGGN
     FKPSQRTFAG GIKSNTDFGS WERHTKGIGQ KLLQKMGYMP GRGLGKNAQG IIAPIEAKQR
     RGKGAVGAYG SERTKQSIKD FPVVDSEEEE EKDFQKEMSQ WRKEPGGGKK KPKYSYKTVE
     ELKAKGRVGK SLSAPQKEIS QVKVIDMTGR EQKVYYSYSQ LAQKHNIPGE APGQGVKEEK
     PQGFALPELE HNLQLLIDMT EQEIIQNDRQ LQYEQDMVVN LTHELEKLSE VLEREDKAIE
     NLSKVLETVE ECERRIQPTC DNPLTLEECA RIFEMLQDKY YEEYKMSEKA DLSVAIVYPL
     MKDYFKDWNP LRDPNYGTDV MSKWKNLLEE GHLSHSAHDA AMDPYHRLLW EMWVPFLRNI
     IAQWQPRNCA PMADFLDSWV HLLPVWILDN ILDQLIFPKL QKEVENWNPL TDTVPIHSWI
     HPWLPMMQSR LEPLFSPIRN KLSNALQKWH PSDSSAKLIL QPWKEVFTPG SWEAFMVKNI
     VPKLGMCLSE FVINPHQQHM EVFHWVTDWE GMVALSSIVG LLEKHFFPKW LQVLCSWLSN
     NPNYEEITKW YLGWKSMFSD LVLAHPAIKD KFNEALDIMN RAVSSSVGAY MQPGARESIA
     YLTQTEKRKD FQYEAMQERR DAESIAQRGI GAAAAVPMNF KDLIQSKAEE HNIVFMPLIG
     KRHEGKQLYN FNRIVIYIDR GVVFVQGEKT WVPTSLQSLI DMAK