ID   TFP11_XENTR             Reviewed;         825 AA.
AC   Q0IIX9; A1XD99;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Tuftelin-interacting protein 11;
DE   AltName: Full=Septin and tuftelin-interacting protein 1;
DE            Short=STIP-1;
GN   Name=tfip11; Synonyms=stip;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=17289020; DOI=10.1016/j.yexcr.2007.01.003;
RA   Ji Q., Huang C.-H., Peng J., Hashmi S., Ye T., Chen Y.;
RT   "Characterization of STIP, a multi-domain nuclear protein, highly conserved
RT   in metazoans, and essential for embryogenesis in Caenorhabditis elegans.";
RL   Exp. Cell Res. 313:1460-1472(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing, specifically in spliceosome
CC       disassembly during late-stage splicing events. {ECO:0000250}.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFP11/STIP family. {ECO:0000305}.
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DR   EMBL; DQ342032; ABC69924.1; -; mRNA.
DR   EMBL; BC121497; AAI21498.1; -; mRNA.
DR   RefSeq; NP_001090845.1; NM_001097376.1.
DR   AlphaFoldDB; Q0IIX9; -.
DR   SMR; Q0IIX9; -.
DR   STRING; 8364.ENSXETP00000008231; -.
DR   PaxDb; Q0IIX9; -.
DR   PRIDE; Q0IIX9; -.
DR   DNASU; 100038256; -.
DR   GeneID; 100038256; -.
DR   KEGG; xtr:100038256; -.
DR   CTD; 24144; -.
DR   Xenbase; XB-GENE-984521; tfip11.
DR   eggNOG; KOG2184; Eukaryota.
DR   InParanoid; Q0IIX9; -.
DR   OrthoDB; 1238995at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000003784; Expressed in blastula and 13 other tissues.
DR   GO; GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
DR   GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000390; P:spliceosomal complex disassembly; IBA:GO_Central.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR022783; GCFC_dom.
DR   InterPro; IPR024933; STIP.
DR   InterPro; IPR022159; STIP/TFIP11_N.
DR   InterPro; IPR045211; TFP11/STIP/Ntr1.
DR   PANTHER; PTHR23329; PTHR23329; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   Pfam; PF07842; GCFC; 1.
DR   Pfam; PF12457; TIP_N; 1.
DR   PIRSF; PIRSF017706; TFIP11; 1.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..825
FT                   /note="Tuftelin-interacting protein 11"
FT                   /id="PRO_0000342282"
FT   DOMAIN          145..191
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          1..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..66
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        357
FT                   /note="K -> Q (in Ref. 2; AAI21498)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        662
FT                   /note="N -> T (in Ref. 2; AAI21498)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   825 AA;  95295 MW;  B557F1B538D98E45 CRC64;
     MSMSHLYGKD EDSDGVEMEN FEITDWDLQN EFNPNRRKHF QTKEEATYGM WAERDSDDER
     PSFGGKRSRD YSAPVNFISA GIRKPAAEEK SDSDSDSETQ ARRETFPKDF EAKKLRTGGN
     FKPSQRTFAG GIKSNTDFGS WERHTKGIGQ KLLQKMGYVQ GRGLGKNAQG IIAPIEAKQR
     KGKGAVGAYG SERTKQSIKD FPVVDSEEEE EKEFQKEMSQ WRKDPGGGKK KPKYSYKTVE
     ELKAKGKVGK SLSAPQKEIS QVKVIDMTGR EQKVYYSYSQ LAHKHNIPGE APGQGAKEEK
     PQGFALPELE HNLQLLIDMT EQEIIQNDRQ LQYEQDMVVN LTHELEKLSE VLEREEKAIQ
     NLSKVLETVE ECERRIQPMC DNPLTLEECA RIFEMLQDKY YEEYKMSEKA DLSVAIVYPL
     MKDYFKDWNP LRDPTYGTDV MSKWKNLLEE GHLLSHSAHD ASMDPYHRLL WETWVPLLRS
     IIAQWQPRNC APMVDFLDCW VHLLPVWILD NILDQLIFPK LQKEVENWNP LTDTVPIHSW
     IHPWLPLMQS RLEPLFSPIR NKLANALQKW HPSDSSAKLI LQPWKEVFTP GSWEAFMVKN
     ILPKLGMCLS EFVINPHQQH MEVFHWVTDW EGMVSLSSIV GILEKHFFPK WLQVLCSWLS
     NNPNYEEITK WYLGWKSMFS DLVLAHPAIK DKFNEALDIM NRAVSSSVGA YMQPGARESI
     AYLTQTERRK DFQYEAMQER RDAESIAQRG IGAAAAVPMN FKDLIQSKAE EHNIVFMPLI
     GKRHEGKQLY NFNRIVIYID RGVVFVQGEK TWVPTSLQSL IDMAK