TFP8L_DROME
ID TFP8L_DROME Reviewed; 188 AA.
AC Q7KVH9; Q9W1L0;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Tumor necrosis factor alpha-induced protein 8-like protein;
DE Short=TNF alpha-induced protein 8-like protein;
GN ORFNames=CG4091;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=A, B;
CC IsoId=Q7KVH9-1; Sequence=Displayed;
CC Name=2; Synonyms=C;
CC IsoId=Q7KVH9-2; Sequence=VSP_024915;
CC -!- SIMILARITY: Belongs to the TNFAIP8 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF47048.1; -; Genomic_DNA.
DR EMBL; AE013599; AAM68269.2; -; Genomic_DNA.
DR EMBL; AY095033; AAM11361.1; -; mRNA.
DR RefSeq; NP_611820.1; NM_137976.3. [Q7KVH9-1]
DR RefSeq; NP_726357.1; NM_166621.2. [Q7KVH9-1]
DR RefSeq; NP_726358.2; NM_166622.2. [Q7KVH9-2]
DR AlphaFoldDB; Q7KVH9; -.
DR SMR; Q7KVH9; -.
DR BioGRID; 63349; 2.
DR IntAct; Q7KVH9; 1.
DR STRING; 7227.FBpp0072006; -.
DR PaxDb; Q7KVH9; -.
DR PRIDE; Q7KVH9; -.
DR DNASU; 37751; -.
DR EnsemblMetazoa; FBtr0072096; FBpp0072005; FBgn0034894. [Q7KVH9-1]
DR EnsemblMetazoa; FBtr0072097; FBpp0072006; FBgn0034894. [Q7KVH9-2]
DR EnsemblMetazoa; FBtr0072098; FBpp0072007; FBgn0034894. [Q7KVH9-1]
DR GeneID; 37751; -.
DR KEGG; dme:Dmel_CG4091; -.
DR UCSC; CG4091-RA; d. melanogaster. [Q7KVH9-1]
DR CTD; 37751; -.
DR FlyBase; FBgn0034894; CG4091.
DR VEuPathDB; VectorBase:FBgn0034894; -.
DR eggNOG; ENOG502S00N; Eukaryota.
DR GeneTree; ENSGT00390000003488; -.
DR HOGENOM; CLU_085918_1_0_1; -.
DR InParanoid; Q7KVH9; -.
DR PhylomeDB; Q7KVH9; -.
DR Reactome; R-DME-1483255; PI Metabolism.
DR BioGRID-ORCS; 37751; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 37751; -.
DR PRO; PR:Q7KVH9; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034894; Expressed in embryonic/larval hemocyte (Drosophila) and 29 other tissues.
DR ExpressionAtlas; Q7KVH9; baseline and differential.
DR Genevisible; Q7KVH9; DM.
DR GO; GO:0042995; C:cell projection; IDA:FlyBase.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ISS:UniProtKB.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IMP:FlyBase.
DR GO; GO:0010506; P:regulation of autophagy; IMP:FlyBase.
DR GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IMP:FlyBase.
DR GO; GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase.
DR Gene3D; 1.20.1440.160; -; 1.
DR InterPro; IPR008477; TNFAIP8-like.
DR InterPro; IPR038355; TNFAIP8_sf.
DR PANTHER; PTHR12757; PTHR12757; 1.
DR Pfam; PF05527; DUF758; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..188
FT /note="Tumor necrosis factor alpha-induced protein 8-like
FT protein"
FT /id="PRO_0000285780"
FT VAR_SEQ 1
FT /note="M -> MSVAGLRQCLLLWSVDYWNLEVM (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_024915"
SQ SEQUENCE 188 AA; 21387 MW; 2C4061A8F43552B9 CRC64;
MADNVFKSHD IGLRAQKKIL SRMATKNIAK TFIDGTTASL LDNLYRLCKM HTGNKAKAEK
LIKNIIKIVI KIGVLHRNNQ FSDEELQKAE LFKRKFQNTQ LSIISFYEVD FTFDLPYLQK
SIAESQVALK SIVQPHLTEK SLGRIDEVFD FFGEEALLET AFRPDSPYRE VMGKIVADIN
AAMETGDI
