TFPT_BOVIN
ID TFPT_BOVIN Reviewed; 251 AA.
AC Q17QH7;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=TCF3 fusion partner homolog;
GN Name=TFPT;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Appears to promote apoptosis in a p53/TP53-independent
CC manner. {ECO:0000250}.
CC -!- FUNCTION: Putative regulatory component of the chromatin remodeling
CC INO80 complex which is involved in transcriptional regulation, DNA
CC replication and probably DNA repair.
CC -!- SUBUNIT: Interacts with NOL3; translocates NOL3 into the nucleus and
CC negatively regulated TFPT-induced cell death. Component of the
CC chromatin remodeling INO80 complex; specifically part of a complex
CC module associated with the N-terminus of INO80 (By similarity).
CC {ECO:0000250, ECO:0000250|UniProtKB:Q9JMG6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; BC118355; AAI18356.1; -; mRNA.
DR RefSeq; NP_001068742.1; NM_001075274.2.
DR AlphaFoldDB; Q17QH7; -.
DR SMR; Q17QH7; -.
DR STRING; 9913.ENSBTAP00000010195; -.
DR PaxDb; Q17QH7; -.
DR Ensembl; ENSBTAT00000010195; ENSBTAP00000010195; ENSBTAG00000007756.
DR GeneID; 506610; -.
DR KEGG; bta:506610; -.
DR CTD; 29844; -.
DR VEuPathDB; HostDB:ENSBTAG00000007756; -.
DR VGNC; VGNC:35795; TFPT.
DR eggNOG; ENOG502RHUP; Eukaryota.
DR GeneTree; ENSGT00390000016605; -.
DR HOGENOM; CLU_096140_0_0_1; -.
DR InParanoid; Q17QH7; -.
DR OMA; NERMLNR; -.
DR OrthoDB; 1308382at2759; -.
DR TreeFam; TF338152; -.
DR ChiTaRS; TFPT; cattle.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000007756; Expressed in laryngeal cartilage and 107 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0031011; C:Ino80 complex; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
DR GO; GO:0097190; P:apoptotic signaling pathway; ISS:UniProtKB.
DR GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0045739; P:positive regulation of DNA repair; IEA:Ensembl.
DR GO; GO:1904507; P:positive regulation of telomere maintenance in response to DNA damage; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:Ensembl.
DR GO; GO:0060382; P:regulation of DNA strand elongation; IEA:Ensembl.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:Ensembl.
DR GO; GO:0000723; P:telomere maintenance; IEA:Ensembl.
DR InterPro; IPR033555; TFPT.
DR PANTHER; PTHR35084; PTHR35084; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; DNA damage; DNA recombination; DNA repair; Isopeptide bond;
KW Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Ubl conjugation.
FT CHAIN 1..251
FT /note="TCF3 fusion partner homolog"
FT /id="PRO_0000254580"
FT REGION 50..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..183
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 167
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P0C1Z6"
FT MOD_RES 172
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P0C1Z6"
FT MOD_RES 180
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P0C1Z6"
FT MOD_RES 188
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P0C1Z6"
FT MOD_RES 207
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P0C1Z6"
FT MOD_RES 247
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P0C1Z6"
FT CROSSLNK 214
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P0C1Z6"
SQ SEQUENCE 251 AA; 28096 MW; 7165956501B84D36 CRC64;
MELEQREGTM AAVGFEEFSA PPGSELALPP LFGGHILESE LETEVEFVSG GLGGSGLRER
DEEEEAARGR RRRQRELNRR KYQALGRRCR EIEQVNERVL NRLHQVQRIT RRLQQERRFL
MRVLDSYGDD YRSSQFTIVL EDEGSQGTDA PTPGNAENEP PDKEGLSPPR RTPAPPEPGS
PAPGEGPSGR KRRRAPRDTR RVGAALTPEL APIKVEEDFG FEADEALDSS WVSRGPDKLL
PYPTLASPPF D
