TFR2_RAT
ID TFR2_RAT Reviewed; 798 AA.
AC B2GUY2;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Transferrin receptor protein 2;
DE Short=TfR2;
GN Name=Tfr2; Synonyms=Trfr2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mediates cellular uptake of transferrin-bound iron in a non-
CC iron dependent manner. May be involved in iron metabolism, hepatocyte
CC function and erythrocyte differentiation (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000305}.
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DR EMBL; CH473973; EDM13257.1; -; Genomic_DNA.
DR EMBL; CH473973; EDM13258.1; -; Genomic_DNA.
DR EMBL; CH473973; EDM13259.1; -; Genomic_DNA.
DR EMBL; BC166451; AAI66451.1; -; mRNA.
DR RefSeq; NP_001099386.1; NM_001105916.1.
DR RefSeq; XP_006249179.1; XM_006249117.2.
DR RefSeq; XP_006249180.1; XM_006249118.1.
DR RefSeq; XP_008767347.1; XM_008769125.2.
DR RefSeq; XP_008767348.1; XM_008769126.1.
DR AlphaFoldDB; B2GUY2; -.
DR SMR; B2GUY2; -.
DR IntAct; B2GUY2; 1.
DR STRING; 10116.ENSRNOP00000001905; -.
DR MEROPS; M28.973; -.
DR GlyGen; B2GUY2; 3 sites.
DR PaxDb; B2GUY2; -.
DR PeptideAtlas; B2GUY2; -.
DR PRIDE; B2GUY2; -.
DR Ensembl; ENSRNOT00000001905; ENSRNOP00000001905; ENSRNOG00000001407.
DR GeneID; 288562; -.
DR KEGG; rno:288562; -.
DR UCSC; RGD:1310152; rat.
DR CTD; 7036; -.
DR RGD; 1310152; Tfr2.
DR eggNOG; KOG2195; Eukaryota.
DR GeneTree; ENSGT01030000234598; -.
DR HOGENOM; CLU_005688_5_0_1; -.
DR InParanoid; B2GUY2; -.
DR OMA; FSQGPHK; -.
DR OrthoDB; 804230at2759; -.
DR PhylomeDB; B2GUY2; -.
DR TreeFam; TF312981; -.
DR Reactome; R-RNO-917977; Transferrin endocytosis and recycling.
DR PRO; PR:B2GUY2; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Proteomes; UP000234681; Chromosome 12.
DR Bgee; ENSRNOG00000001407; Expressed in liver and 8 other tissues.
DR Genevisible; B2GUY2; RN.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISO:RGD.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
DR GO; GO:1990712; C:HFE-transferrin receptor complex; ISO:RGD.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:RGD.
DR GO; GO:0039706; F:co-receptor binding; ISO:RGD.
DR GO; GO:0004998; F:transferrin receptor activity; ISO:RGD.
DR GO; GO:0006953; P:acute-phase response; IEP:RGD.
DR GO; GO:0071281; P:cellular response to iron ion; ISO:RGD.
DR GO; GO:0140298; P:endocytic iron import into cell; ISO:RGD.
DR GO; GO:0055072; P:iron ion homeostasis; ISO:RGD.
DR GO; GO:0045807; P:positive regulation of endocytosis; ISO:RGD.
DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; ISO:RGD.
DR GO; GO:1903319; P:positive regulation of protein maturation; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0006898; P:receptor-mediated endocytosis; ISO:RGD.
DR GO; GO:0010039; P:response to iron ion; ISO:RGD.
DR GO; GO:0033572; P:transferrin transport; ISO:RGD.
DR CDD; cd02128; PA_TfR; 1.
DR Gene3D; 1.20.930.40; -; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR InterPro; IPR037324; TfR1/2_PA.
DR PANTHER; PTHR10404; PTHR10404; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF47672; SSF47672; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..798
FT /note="Transferrin receptor protein 2"
FT /id="PRO_0000348233"
FT TOPO_DOM 1..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..798
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 25..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 23..26
FT /note="Endocytosis signal"
FT /evidence="ECO:0000255"
FT CARBOHYD 235
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 334
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 535
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106
FT /note="Interchain"
FT /evidence="ECO:0000255"
FT DISULFID 109
FT /note="Interchain"
FT /evidence="ECO:0000255"
SQ SEQUENCE 798 AA; 88328 MW; 2EFF8F3D965D85B0 CRC64;
MEQRWGLLRK VQQWSPRPSQ TIYRRVEGPQ LENLEEEDRE EGEELPAQFC PMELKGPERL
GSCPGRSIPI PWAAAGRKAA PYLVLTTLLI FTGAFLLGYV AFRGSCQACG DSVLVVGEDV
NSEDSSRGTL YWSDLQDMFL RFLGEGRMED TIRLTSLRER VAGSARMATL VQDILDKLSR
QKLDHVWTDT HYVGLQFPDP AHPNTLHWVG ADGSVQEQLP LEDPEVYCPY SATGNATGKL
VYAHYGRRED LQDLKAKDVE LAGSLLLVRA GITSFAQKVA IAQDFGAHGV LIYPDPADFS
QDPHKPGLSS DRAVYGHVHL GTGDPYTPGF PSFNQTQFPP VESSGLPNIP AQPISADVAD
RLLRKLTGPV APQEWKGRLS DSPYRLGPGP GLRLVVNNHR TSTPISNIFA CIEGFAEPDH
YVVIGAQRDA WGPGAAKSAV GTAILLELVR TFSSMVSSGF RPRRSLLFIS WDGGDFGSVG
ATEWLEGYLS VLHLKAVVYV SLDNSVLGDG KFHAKTSPLL VSLIENILKQ VDSPNHSGQT
LYDQVAFTHP SWDAEVIQPL PMDSSAYSFT AFAGVPAVEF SFMEDDRVYP FLHTKEDTYE
NLHKMLRGRL PAVVLAVAQL AGQLLIRLSH DHLLPLDFGR YGDVVLRHIG NLNEFSGDLK
ARGLTLQWVY SARGDYIRAA EKLRKEIYSS EQSDERLMRM YNVRIMRVEF YFLSQYVSPA
DSPFRHIFLG QGDHTLGALV EHLRMLRSDG SGAASSGLSP GLGFQESRFR RQLALLTWTL
QGAANALSGD VWNIDNNF
