ID   TFTE_BURCE              Reviewed;         352 AA.
AC   Q45072;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Maleylacetate reductase;
DE            EC=1.3.1.32;
GN   Name=tftE;
OS   Burkholderia cepacia (Pseudomonas cepacia).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AC1100;
RX   PubMed=7538273; DOI=10.1128/aem.61.4.1279-1289.1995;
RA   Daubaras D.L., Hershberger C.D., Kitano K., Chakrabarty A.M.;
RT   "Sequence analysis of a gene cluster involved in metabolism of 2,4,5-
RT   trichlorophenoxyacetic acid by Burkholderia cepacia AC1100.";
RL   Appl. Environ. Microbiol. 61:1279-1289(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-oxoadipate + NAD(+) = H(+) + maleylacetate + NADH;
CC         Xref=Rhea:RHEA:16981, ChEBI:CHEBI:15378, ChEBI:CHEBI:15775,
CC         ChEBI:CHEBI:16468, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.32;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-oxoadipate + NADP(+) = H(+) + maleylacetate + NADPH;
CC         Xref=Rhea:RHEA:16985, ChEBI:CHEBI:15378, ChEBI:CHEBI:15775,
CC         ChEBI:CHEBI:16468, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.32;
CC   -!- PATHWAY: Xenobiotic degradation; (2,4,5-trichlorophenoxy)acetate
CC       degradation.
CC   -!- SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase
CC       family. {ECO:0000305}.
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DR   EMBL; U19883; AAC43333.1; -; Genomic_DNA.
DR   PIR; I40177; I40177.
DR   AlphaFoldDB; Q45072; -.
DR   SMR; Q45072; -.
DR   BioCyc; MetaCyc:MON-14680; -.
DR   UniPathway; UPA00686; -.
DR   GO; GO:0018506; F:maleylacetate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0046228; P:2,4,5-trichlorophenoxyacetic acid catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd08177; MAR; 1.
DR   InterPro; IPR001670; ADH_Fe/GldA.
DR   InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR   InterPro; IPR034786; MAR.
DR   PANTHER; PTHR11496; PTHR11496; 1.
DR   Pfam; PF00465; Fe-ADH; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; NAD; Oxidoreductase.
FT   CHAIN           1..352
FT                   /note="Maleylacetate reductase"
FT                   /id="PRO_0000087853"
SQ   SEQUENCE   352 AA;  36823 MW;  FD7F0F8959357044 CRC64;
     MNAFLFEARI PRVVFGAGAL QHLVREIDAM GSTRALVLST PEQSADAERV AGILGSRAVG
     VFPRATMHVP IELAREARLE ASRLGADCAV AIGGGSTTGL GKAIALESGL PILSIPTTYA
     GSEMTPIYGV TDNGVKQTGR DARVLPRTVI YDPELTLGLP IRMTVSSGLN AIAHAAESLY
     AHDGNPVIGL MAEEGIRAIG AALTPLQANP ADLVARSDAL YGAWLCGAVL GAVSMGLHHK
     LCHTLGGAFN LPHAELHTVI LPHALAYNSA RASQAMERIA RALGVSSAPR GLFDLAERSG
     LPVSLAALGM PREGIELAAD MAVKNPYPNP RPLERDAIRV LLEHAYDGVR PS