ID   TFX_METTH               Reviewed;         138 AA.
AC   O27001;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2003, sequence version 3.
DT   25-MAY-2022, entry version 147.
DE   RecName: Full=DNA-binding protein Tfx;
GN   Name=tfx; OrderedLocusNames=MTH_916;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Transcriptional activator of the fmdECB operon.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Tfx family. {ECO:0000255|HAMAP-
CC       Rule:MF_00620}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB85414.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000666; AAB85414.1; ALT_INIT; Genomic_DNA.
DR   PIR; F69222; F69222.
DR   PDB; 1NR3; NMR; -; A=17-138.
DR   PDBsum; 1NR3; -.
DR   AlphaFoldDB; O27001; -.
DR   BMRB; O27001; -.
DR   SMR; O27001; -.
DR   STRING; 187420.MTH_916; -.
DR   DNASU; 1471324; -.
DR   EnsemblBacteria; AAB85414; AAB85414; MTH_916.
DR   KEGG; mth:MTH_916; -.
DR   HOGENOM; CLU_125807_0_1_2; -.
DR   OMA; VKVPYST; -.
DR   EvolutionaryTrace; O27001; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   Gene3D; 3.30.1190.10; -; 1.
DR   HAMAP; MF_00620; HTH_type_Tfx; 1.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR029291; Tfx_C.
DR   InterPro; IPR004645; Tfx_DNA-bd_arc.
DR   InterPro; IPR018384; Tfx_DNA-bd_euryarc.
DR   InterPro; IPR036657; Tfx_DNA-bd_sf_arc.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   Pfam; PF14601; TFX_C; 1.
DR   PIRSF; PIRSF004932; DNA_bind_Tfx; 1.
DR   SUPFAM; SSF89915; SSF89915; 1.
DR   TIGRFAMs; TIGR00721; tfx; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..138
FT                   /note="DNA-binding protein Tfx"
FT                   /id="PRO_0000144167"
FT   HELIX           28..33
FT                   /evidence="ECO:0007829|PDB:1NR3"
FT   STRAND          36..38
FT                   /evidence="ECO:0007829|PDB:1NR3"
FT   HELIX           41..46
FT                   /evidence="ECO:0007829|PDB:1NR3"
FT   STRAND          50..53
FT                   /evidence="ECO:0007829|PDB:1NR3"
FT   HELIX           55..62
FT                   /evidence="ECO:0007829|PDB:1NR3"
FT   STRAND          66..70
FT                   /evidence="ECO:0007829|PDB:1NR3"
FT   HELIX           73..75
FT                   /evidence="ECO:0007829|PDB:1NR3"
FT   HELIX           76..90
FT                   /evidence="ECO:0007829|PDB:1NR3"
FT   HELIX           98..108
FT                   /evidence="ECO:0007829|PDB:1NR3"
FT   STRAND          110..112
FT                   /evidence="ECO:0007829|PDB:1NR3"
FT   STRAND          118..120
FT                   /evidence="ECO:0007829|PDB:1NR3"
FT   STRAND          122..135
FT                   /evidence="ECO:0007829|PDB:1NR3"
SQ   SEQUENCE   138 AA;  16083 MW;  76B7B2BB7E45FBE7 CRC64;
     MSKKTFLTER QKTVLEMRER GWSQKKIARE LKTTRQNVSA IERKAMENIE KSRNTLDFVK
     SLKSPVRILC RRGDTLDEII KRLLEESNKE GIHVIHDSIT LAFLIREKAS HRIVHRVVKS
     DFEIGVTRDG EIIVDLNS