ID   TFX_METTM               Reviewed;         138 AA.
AC   P56811; D9PXE4;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2003, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=DNA-binding protein Tfx;
GN   Name=tfx; OrderedLocusNames=MTBMA_c13040;
OS   Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM
OS   14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium
OS   thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=79929;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC   Marburg;
RX   PubMed=10027980; DOI=10.1046/j.1365-2958.1999.01204.x;
RA   Hochheimer A., Hedderich R., Thauer R.K.;
RT   "The DNA binding protein Tfx from Methanobacterium thermoautotrophicum:
RT   structure, DNA binding properties and transcriptional regulation.";
RL   Mol. Microbiol. 31:641-650(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC   Marburg;
RX   PubMed=20802048; DOI=10.1128/jb.00844-10;
RA   Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H.,
RA   Gottschalk G., Thauer R.K.;
RT   "Complete genome sequence of Methanothermobacter marburgensis, a
RT   methanoarchaeon model organism.";
RL   J. Bacteriol. 192:5850-5851(2010).
CC   -!- FUNCTION: Transcriptional activator of the fmdECB operon.
CC       {ECO:0000269|PubMed:10027980}.
CC   -!- SIMILARITY: Belongs to the Tfx family. {ECO:0000255|HAMAP-
CC       Rule:MF_00620}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ADL58892.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AJ009686; CAA08778.1; -; Genomic_DNA.
DR   EMBL; CP001710; ADL58892.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_074359241.1; NC_014408.1.
DR   AlphaFoldDB; P56811; -.
DR   BMRB; P56811; -.
DR   SMR; P56811; -.
DR   STRING; 79929.MTBMA_c13040; -.
DR   EnsemblBacteria; ADL58892; ADL58892; MTBMA_c13040.
DR   GeneID; 9705012; -.
DR   KEGG; mmg:MTBMA_c13040; -.
DR   HOGENOM; CLU_125807_0_1_2; -.
DR   OMA; VKVPYST; -.
DR   OrthoDB; 96651at2157; -.
DR   Proteomes; UP000000345; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   Gene3D; 3.30.1190.10; -; 1.
DR   HAMAP; MF_00620; HTH_type_Tfx; 1.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR029291; Tfx_C.
DR   InterPro; IPR004645; Tfx_DNA-bd_arc.
DR   InterPro; IPR018384; Tfx_DNA-bd_euryarc.
DR   InterPro; IPR036657; Tfx_DNA-bd_sf_arc.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   Pfam; PF14601; TFX_C; 1.
DR   PIRSF; PIRSF004932; DNA_bind_Tfx; 1.
DR   SUPFAM; SSF89915; SSF89915; 1.
DR   TIGRFAMs; TIGR00721; tfx; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..138
FT                   /note="DNA-binding protein Tfx"
FT                   /id="PRO_0000144168"
SQ   SEQUENCE   138 AA;  16143 MW;  6DAD030B7E55EAE6 CRC64;
     MSKKTFLTER QKTVLEMRER GWSQKKIARE LKTTRQNVSA IERKAMENIE KSRNTLDFVK
     FLKSPVRILC RRGDTLDEII KRLLEESNKE GIHVIHDSIT LAFLIREKAS HRIVHRVVKS
     DFEIGVTRDG EIIVDLNS