BRE1B_ORYSI
ID BRE1B_ORYSI Reviewed; 844 AA.
AC A2ZAC2; B8BIA7;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=E3 ubiquitin-protein ligase BRE1-like 2;
DE EC=2.3.2.27 {ECO:0000250|UniProtKB:Q9C895};
DE AltName: Full=RING-type E3 ubiquitin transferase BRE1-like 2 {ECO:0000305};
GN Name=BRE1B; ORFNames=OsI_34687;
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: E3 ubiquitin-protein ligase that monoubiquitinates H2B to
CC form H2BK143ub1. H2BK143ub1 gives a specific tag for epigenetic
CC transcriptional activation and is also prerequisite for H3K4me and
CC maybe H3K79me. It thereby plays a central role in histone code and gene
CC regulation. Forms a ubiquitin ligase complex in cooperation with the E2
CC enzyme UBC2/RAD6. {ECO:0000250|UniProtKB:Q9C895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000250|UniProtKB:Q9C895};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9C895}.
CC -!- DOMAIN: The RING-type zinc finger domain mediates binding to an E2
CC ubiquitin-conjugating enzyme. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BRE1 family. {ECO:0000305}.
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DR EMBL; CM000135; EEC67460.1; -; Genomic_DNA.
DR AlphaFoldDB; A2ZAC2; -.
DR SMR; A2ZAC2; -.
DR STRING; 39946.A2ZAC2; -.
DR PRIDE; A2ZAC2; -.
DR EnsemblPlants; BGIOSGA033459-TA; BGIOSGA033459-PA; BGIOSGA033459.
DR Gramene; BGIOSGA033459-TA; BGIOSGA033459-PA; BGIOSGA033459.
DR HOGENOM; CLU_002640_1_0_1; -.
DR OMA; DENTSCT; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000007015; Chromosome 10.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:EnsemblPlants.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0044260; P:cellular macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0033523; P:histone H2B ubiquitination; IEA:EnsemblPlants.
DR GO; GO:0010390; P:histone monoubiquitination; IEA:EnsemblPlants.
DR GO; GO:0045087; P:innate immune response; IEA:EnsemblPlants.
DR GO; GO:0009965; P:leaf morphogenesis; IEA:EnsemblPlants.
DR GO; GO:0010162; P:seed dormancy process; IEA:EnsemblPlants.
DR GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IEA:EnsemblPlants.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR013956; E3_ubiquit_lig_Bre1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23163; PTHR23163; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Coiled coil; Metal-binding; Nucleus;
KW Reference proteome; Transferase; Ubl conjugation pathway; Zinc;
KW Zinc-finger.
FT CHAIN 1..844
FT /note="E3 ubiquitin-protein ligase BRE1-like 2"
FT /id="PRO_0000293113"
FT ZN_FING 792..831
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 244..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..38
FT /evidence="ECO:0000255"
FT COILED 160..240
FT /evidence="ECO:0000255"
FT COILED 290..604
FT /evidence="ECO:0000255"
FT COILED 640..670
FT /evidence="ECO:0000255"
FT COMPBIAS 244..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 844 AA; 96498 MW; 2A57EDD94FDE5E94 CRC64;
MDAAALQYEN QKLVQQLEAQ KSKMRALEGK FKELRDEQCS YDNTLICLNK MWNQLIDDLV
LLGVRAGGDL NGLQALDHEE MSEESLESCP SEEIFLFRLL NSRNFRNNDD SSLSKLVEEA
LALRYSTTVT LMKSLQEAFA VQQARSESLS LALNGQNSSE DVIVALENHN DYLKEVVDNL
RQAVSIINRK HEKYLDEIEA FKNNQSRELH EVKCLSGELE ESMAELEESR RKLAVLQLQT
GGGSLMNTSA PNGVNGSVST DKSSDKGMGW RDLKDAVEEA KTLAANRLFE LHETQEDNLI
LSKQLEDIQD QLKDENYIVT SKPYTILSDQ LHHLNAEIER YRGLVEVLQN EKDQLMQKEE
EMLAKAESVD AVQQSITTYK AKIEDLEHEI QKLMAEKNDL EIKAEEALQD SGKKDFKDEI
HVMAASLSKE MELLDNQMNR SKDAASEALA LREEADYLRT LLAKKIDEQK EISDRYNTQV
TEIKSLKALI ETLDQEKQEL QFIVDMLGKE CSESRAISEI EESENRARKQ AEYLRKCLEE
HNLELRVKAA NEAETACQQR LSIAEAELED LRAKVDASER DVMKLKESIR IKEAEVDGHI
SEIETIGQAY EDMQTQNQHL LQQVADRDDF NIKLVSDSVK MKQAYGSLLA EKNMLQKQLQ
HVNSSLESSK LKITSGEEQM KTYVAQAMKS SSENRHLAIS LERTMLEVSD AEKELKWLRS
ATGSAEKEYE INQKKIAELK MELERERNER IKLEEEYEEV KNEVSELTSE TEETTIQKLQ
DEIKECKAIL KCGVCFDRPK EVVITKCFHL FCSPCIQRNL EIRHRKCPGC GTPFGQSDVR
EVKI
