TG198_CAEEL
ID TG198_CAEEL Reviewed; 367 AA.
AC P34387; Q9NCF7;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2002, sequence version 2.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=Cell-death-related nuclease 7;
DE EC=3.1.-.-;
DE Flags: Precursor;
GN Name=crn-7; Synonyms=tag-198; ORFNames=F09G8.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 26-357.
RX PubMed=10903447; DOI=10.1016/s0378-1119(00)00209-2;
RA Krieser R.J., Eastman A.;
RT "Deoxyribonuclease II: structure and chromosomal localization of the murine
RT gene, and comparison with the genomic structure of the human and three C.
RT elegans homologs.";
RL Gene 252:155-162(2000).
CC -!- SIMILARITY: Belongs to the DNase II family. {ECO:0000305}.
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DR EMBL; FO080289; CCD62642.1; -; Genomic_DNA.
DR EMBL; AF220526; AAF43009.1; -; mRNA.
DR PIR; S44793; S44793.
DR RefSeq; NP_498817.1; NM_066416.3.
DR AlphaFoldDB; P34387; -.
DR SMR; P34387; -.
DR STRING; 6239.F09G8.2; -.
DR PaxDb; P34387; -.
DR PeptideAtlas; P34387; -.
DR EnsemblMetazoa; F09G8.2.1; F09G8.2.1; WBGene00007056.
DR GeneID; 176166; -.
DR KEGG; cel:CELE_F09G8.2; -.
DR UCSC; F09G8.2; c. elegans.
DR CTD; 176166; -.
DR WormBase; F09G8.2; CE20662; WBGene00007056; crn-7.
DR eggNOG; KOG3825; Eukaryota.
DR GeneTree; ENSGT00390000002634; -.
DR HOGENOM; CLU_053867_0_1_1; -.
DR InParanoid; P34387; -.
DR OMA; ILYNDQK; -.
DR OrthoDB; 605654at2759; -.
DR PhylomeDB; P34387; -.
DR BRENDA; 3.1.22.1; 1045.
DR Reactome; R-CEL-432720; Lysosome Vesicle Biogenesis.
DR PRO; PR:P34387; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00007056; Expressed in material anatomical entity and 4 other tissues.
DR GO; GO:0004531; F:deoxyribonuclease II activity; IMP:WormBase.
DR GO; GO:0006309; P:apoptotic DNA fragmentation; IMP:WormBase.
DR GO; GO:0002785; P:negative regulation of antimicrobial peptide production; IMP:WormBase.
DR InterPro; IPR004947; DNase_II.
DR PANTHER; PTHR10858; PTHR10858; 1.
DR Pfam; PF03265; DNase_II; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Hydrolase; Reference proteome; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..367
FT /note="Cell-death-related nuclease 7"
FT /id="PRO_0000007300"
FT CARBOHYD 253
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 305
FT /note="G -> E (in Ref. 3; AAF43009)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 367 AA; 41231 MW; 599D082D870A7555 CRC64;
MRLYFVLIFS VIFTTGNGKI QCKNMRGKSV DWFVVYKLPK LSGAGTSGKE FVYFDAESSD
WTRGNDINDP NVAVGATVSQ VYSADKSNNF WFMYSDDDPI KSADSYRGHA KGVSLFDSTT
GFWLIHSVPN FPPIKSFSYP NTAEKYGQSF FCASMEVQHL TELAEHWKYI QATPYIINIP
EKYATRFPTL KNVEAKQSLP RSATQFWISK PIKTVQGVTL MAYAKHKKFD GDIWNDLISR
QNKVTLAVES WLNGSGDDIH TTCTSTSQTH DVTEMRVTGL NFASSKDHSK WAVSNSQTNP
IVCFGDMNRQ KSQLKRGGGA LCIQNRNLWQ LYHSFVIQVE PCKSSSHFSM FQTIATLLSA
AGLVSKI
