TG325_CAEEL
ID TG325_CAEEL Reviewed; 837 AA.
AC P46941;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=WW domain-containing protein tag-325;
GN Name=tag-325; ORFNames=C38D4.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; Z46241; CAA86318.1; -; Genomic_DNA.
DR PIR; T19825; T19825.
DR RefSeq; NP_001309440.1; NM_001322567.1.
DR AlphaFoldDB; P46941; -.
DR SMR; P46941; -.
DR BioGRID; 40870; 10.
DR DIP; DIP-24380N; -.
DR STRING; 6239.C38D4.5; -.
DR iPTMnet; P46941; -.
DR EPD; P46941; -.
DR PaxDb; P46941; -.
DR PeptideAtlas; P46941; -.
DR EnsemblMetazoa; C38D4.5a.1; C38D4.5a.1; WBGene00008006.
DR GeneID; 175636; -.
DR KEGG; cel:CELE_C38D4.5; -.
DR UCSC; C38D4.5.1; c. elegans.
DR CTD; 175636; -.
DR WormBase; C38D4.5a; CE51454; WBGene00008006; tag-325.
DR eggNOG; KOG1450; Eukaryota.
DR GeneTree; ENSGT00950000182860; -.
DR HOGENOM; CLU_339560_0_0_1; -.
DR InParanoid; P46941; -.
DR OMA; ICQHENS; -.
DR OrthoDB; 369126at2759; -.
DR PhylomeDB; P46941; -.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR Reactome; R-CEL-8980692; RHOA GTPase cycle.
DR Reactome; R-CEL-9013148; CDC42 GTPase cycle.
DR Reactome; R-CEL-9013149; RAC1 GTPase cycle.
DR Reactome; R-CEL-9013405; RHOD GTPase cycle.
DR Reactome; R-CEL-9013424; RHOV GTPase cycle.
DR Reactome; R-CEL-9035034; RHOF GTPase cycle.
DR SignaLink; P46941; -.
DR PRO; PR:P46941; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00008006; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR ExpressionAtlas; P46941; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043087; P:regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.10.555.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR SUPFAM; SSF51045; SSF51045; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome.
FT CHAIN 1..837
FT /note="WW domain-containing protein tag-325"
FT /id="PRO_0000076097"
FT DOMAIN 96..129
FT /note="WW"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 386..505
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 610..827
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 837 AA; 94196 MW; D1895E622D1F5997 CRC64;
MTTAVQPSDT TGFGGGPAGS RASDLIQFQE IMSESAESSS SSSQTNVSAA NTLPRESNGQ
NYADDPSHVY TNIREIEELN SRPVPPTPRA DAQPRRDLLN GWFEYETDVG RTFFFNKETG
KSQWIPPRFI RTPAQVQEFL RATRTNLDTT CSFQGSSTSS SEEQKENKMR ESLADDDRKS
QLIEDEEVFD EVCDDVDEQS SPVIDLQSRP LPIPFSDSFT DDEDEDDVKP IEGSIASDSD
FDEEPVPTSS RKASTASGVM MPHPYAHVSS FQSTFPRAKN EDTDKLASYV IPPDANETSK
TPTAIRVRRP SPTNLRSVSF QNKCTVLKNV PMPQVLPTTS SSFDHHPQYH SNTPDRPILM
EDSADFTPSS RCEERRGSGD GREPVRTIRC GDLERSENDE PAEKVVKPKK REWITNYMYL
TTAHLILYKD QKSAEKHGKH YDAPQGVWDL RGASVTWYQD NRDVQKKKQR KYIQLELCNT
KKYLLRGPND TEAVEWYKSL EEVVAKLPSP GSSNQPMIDV TNGVARNPSY IGSTRPLSHA
LIPISRSMRR RDDPMSQSAI ETVSTSVSTD EPRPSKETII EKLRRFFRTR PTVESLKEKG
IYKPEPVFGS TLSAICQHEN SLVPKFIRVI TEVIESKGLE TDGIYRVSGN LSAVQKIRCQ
ADQDNYKALV SEEDIHVLTG ALKLFFRELT DPLFPISLHK EYTSAMQMPN ATTRFKKFEE
LLSRLPNENR ETLKMLLRHL NRVASHSSQN RMQQHNLAIV FGPTLFHNGD GAVNLATKNK
KAGKKAKPSK KEETQATPVQ SNSHLAFSMI MQSQIVQYLL ESANKFDILK APVNIGR
