TGA1A_TOBAC
ID TGA1A_TOBAC Reviewed; 359 AA.
AC P14232;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=TGACG-sequence-specific DNA-binding protein TGA-1A;
DE Short=ASF-1 protein;
DE Short=TGA1a;
GN Name=TGA1A; Synonyms=TGA1;
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2528073; DOI=10.1038/340727a0;
RA Katagiri F., Lam E., Chua N.H.;
RT "Two tobacco DNA-binding proteins with homology to the nuclear factor
RT CREB.";
RL Nature 340:727-730(1989).
RN [2]
RP DNA-BINDING.
RX PubMed=7479010; DOI=10.1093/nar/23.18.3778;
RA Lam E., Lam Y.K.;
RT "Binding site requirements and differential representation of TGF factors
RT in nuclear ASF-1 activity.";
RL Nucleic Acids Res. 23:3778-3785(1995).
CC -!- FUNCTION: Transcriptional activator that binds specifically to the DNA
CC sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of
CC the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis
CC elements mediate auxin- and salicylic acid-inducible transcription.
CC Could also bind to the Hex-motif (5'-TGACGTGG-3') another cis-acting
CC element found in plant histone promoters.
CC -!- SUBUNIT: Binds DNA as a dimer.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; X16449; CAA34468.1; -; mRNA.
DR PIR; S05452; S05452.
DR AlphaFoldDB; P14232; -.
DR IntAct; P14232; 1.
DR STRING; 4097.P14232; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR025422; TGA_domain.
DR Pfam; PF00170; bZIP_1; 1.
DR Pfam; PF14144; DOG1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
DR PROSITE; PS51806; DOG1; 1.
PE 1: Evidence at protein level;
KW Activator; Coiled coil; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..359
FT /note="TGACG-sequence-specific DNA-binding protein TGA-1A"
FT /id="PRO_0000076546"
FT DOMAIN 72..135
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT DOMAIN 143..354
FT /note="DOG1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01147"
FT REGION 44..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..94
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 100..114
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT COILED 73..125
FT /evidence="ECO:0000255"
SQ SEQUENCE 359 AA; 40701 MW; 167FC8DB03CAEA76 CRC64;
MGICDPIHQL GMWDDFNSSF PSTSATMILE VDKCLEDQIP IMEKRLDNET EDTSHGTVGT
SNRYEPETSK PVEKVLRRLA QNREAARKSR LRKKAYVQQL ENSKLKLIQL EQELERARKQ
GMCVGGGVDA SQLSYSGTAS SGTAVFDMEY GHWVEEQTRQ TNDLRIALHS QIGEAELRII
VDGYLNHYFD LFRMKATAAK ADVLYIMSGM WKTSAERFFM WIGGFRPSEL LKVLTPHLEL
LTEQQLREVC NLTQSCQQAE DALSQGMVKL HQILAEAVAA GRLGEGNYTL PQMGPAIEKL
EDLVRFVNQA DHLRQETLQQ MSRILNTCQA AQGLLALGEY FERLRVLSSQ WATRLREPT
