ID   TGAP1_MOUSE             Reviewed;         505 AA.
AC   P0CAX8; Q8K2L9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=T-cell activation GTPase-activating protein 1;
GN   Name=Tagap1; ORFNames=Fksg15;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wang Y.-G., Gong L.;
RT   "FKSG15, a novel 57 kDa protein, shares the N-terminal region with FOP.";
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- CAUTION: Previously thought to be the same gene as Tagap. These are
CC       distinct loci that encode proteins with identical C-termini but each
CC       with a unique N-terminus. {ECO:0000305}.
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DR   EMBL; AF314818; AAL16686.1; -; mRNA.
DR   EMBL; AC122413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS49940.1; -.
DR   RefSeq; NP_671511.2; NM_147155.2.
DR   AlphaFoldDB; P0CAX8; -.
DR   SMR; P0CAX8; -.
DR   STRING; 10090.ENSMUSP00000070466; -.
DR   MaxQB; P0CAX8; -.
DR   PaxDb; P0CAX8; -.
DR   PeptideAtlas; P0CAX8; -.
DR   PRIDE; P0CAX8; -.
DR   ProteomicsDB; 262807; -.
DR   DNASU; 380608; -.
DR   Ensembl; ENSMUST00000063683; ENSMUSP00000070466; ENSMUSG00000052031.
DR   GeneID; 380608; -.
DR   KEGG; mmu:380608; -.
DR   UCSC; uc008aia.1; mouse.
DR   CTD; 380608; -.
DR   MGI; MGI:1919786; Tagap1.
DR   VEuPathDB; HostDB:ENSMUSG00000052031; -.
DR   eggNOG; KOG4724; Eukaryota.
DR   GeneTree; ENSGT00940000157993; -.
DR   HOGENOM; CLU_014209_1_0_1; -.
DR   InParanoid; P0CAX8; -.
DR   OMA; FQHVDSR; -.
DR   OrthoDB; 1880863at2759; -.
DR   PhylomeDB; P0CAX8; -.
DR   TreeFam; TF331062; -.
DR   BioGRID-ORCS; 380608; 3 hits in 38 CRISPR screens.
DR   PRO; PR:P0CAX8; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; P0CAX8; protein.
DR   Bgee; ENSMUSG00000052031; Expressed in spermatocyte and 62 other tissues.
DR   Genevisible; P0CAX8; MM.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..505
FT                   /note="T-cell activation GTPase-activating protein 1"
FT                   /id="PRO_0000379567"
FT   REGION          81..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          242..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          311..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          414..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..201
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..280
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        318..339
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        114
FT                   /note="A -> T (in Ref. 1; AAL16686)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        130
FT                   /note="G -> S (in Ref. 1; AAL16686)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        156
FT                   /note="N -> S (in Ref. 1; AAL16686)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   505 AA;  55747 MW;  31DF2AFA1D14303B CRC64;
     MAATTAAVVA EEDTELRDLL VQTLENSGVL NRIKAELRAA VFLALEEQEK VEVKILVEFL
     IDNCFEIFGE NIRTRSRITS DDSLEHTDSS DVSTLQNDSA YDSNDPDVEP TSGAASPNRQ
     LEGPTPTMAG LDTRGHRDTC ESSSESSVSM VVRLKNSIVQ QDRRFSEPNM SPSRECLVGP
     TSKQKLTRSE DSFTLSQDAS CSEGDEAEDP FTEEVFPAVD SKPKRPVDLK IKNWTQGLAS
     PQGHITKAFS RSSPGESLGS SPVPSPSCPK RNFFTRHQSF TTKTDKTKPQ REIRKHSMLF
     SFASHKKVLP RTSSIGSEKS KDFSRDQLQK DLRKESQLSG RIVQENESEI QSQTSLGFSL
     SGTWALSVDN TFQLVDMRKP GSPPSYEEAI YYQTSGLTAY GGQTVGSMRS RMFKPSTAVP
     PVPSHHGGDL SEGTPGGHRL SSVTEHWTHS QTVHVSIETQ GRSELHQLRT VSESMQKAKL
     DCLGPQHSHL VFEADQLCCA RESYI