ID   TGB1_BNYVS              Reviewed;         384 AA.
AC   Q65674;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Movement protein TGB1;
DE   AltName: Full=P42;
DE   AltName: Full=Triple gene block 1 protein;
DE            Short=TGBp1;
GN   ORFNames=ORF4;
OS   Beet necrotic yellow vein virus (isolate Japan/S) (BNYVV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Hepelivirales; Benyviridae; Benyvirus.
OX   NCBI_TaxID=652670;
OH   NCBI_TaxID=343494; Beta macrocarpa (Beet) (Beta vulgaris subsp. macrocarpa).
OH   NCBI_TaxID=161934; Beta vulgaris (Sugar beet).
OH   NCBI_TaxID=3562; Spinacia oleracea (Spinach).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8973531; DOI=10.1007/bf01718223;
RA   Saito M., Kiguchi T., Kusume T., Tamada T.;
RT   "Complete nucleotide sequence of the Japanese isolate S of beet necrotic
RT   yellow vein virus RNA and comparison with European isolates.";
RL   Arch. Virol. 141:2163-2175(1996).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=10796018; DOI=10.1094/mpmi.2000.13.5.520;
RA   Erhardt M., Morant M., Ritzenthaler C., Stussi-Garaud C., Guilley H.,
RA   Richards K., Jonard G., Bouzoubaa S., Gilmer D.;
RT   "P42 movement protein of Beet necrotic yellow vein virus is targeted by the
RT   movement proteins P13 and P15 to punctate bodies associated with
RT   plasmodesmata.";
RL   Mol. Plant Microbe Interact. 13:520-528(2000).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=16023167; DOI=10.1016/j.virol.2005.06.012;
RA   Erhardt M., Vetter G., Gilmer D., Bouzoubaa S., Richards K., Jonard G.,
RA   Guilley H.;
RT   "Subcellular localization of the triple gene block movement proteins of
RT   Beet necrotic yellow vein virus by electron microscopy.";
RL   Virology 340:155-166(2005).
CC   -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC       through plasmodesmata, without any budding. The movement protein allows
CC       efficient cell to cell propagation, by bypassing the host cell wall
CC       barrier. Engages in homologous interactions leading to the formation of
CC       a ribonucleoprotein complex containing viral genomic and messenger RNAs
CC       (vRNPs). TGBp2 and TGBp3 are necessary for intracellular delivery of
CC       TGBp1-containing vRNPs to plasmodesmata (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with movement protein TGB3 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cell junction, host plasmodesma
CC       {ECO:0000269|PubMed:10796018, ECO:0000269|PubMed:16023167}.
CC   -!- SIMILARITY: Belongs to the virgaviridae/benyvirus TGB1 movement protein
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D84411; BAA12342.1; -; Genomic_RNA.
DR   RefSeq; NP_612617.1; NC_003515.1.
DR   SMR; Q65674; -.
DR   GeneID; 991084; -.
DR   KEGG; vg:991084; -.
DR   Proteomes; UP000001100; Genome.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01443; Viral_helicase1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51657; PSRV_HELICASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Host cell junction; Nucleotide-binding;
KW   Reference proteome; Transport; Viral movement protein.
FT   CHAIN           1..384
FT                   /note="Movement protein TGB1"
FT                   /id="PRO_5000140117"
FT   DOMAIN          88..238
FT                   /note="(+)RNA virus helicase ATP-binding"
FT   DOMAIN          239..384
FT                   /note="(+)RNA virus helicase C-terminal"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         123..130
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   384 AA;  41976 MW;  1188D32A3C9D2A63 CRC64;
     MVQVQRRTGG DKGAKGNRAS SAPVRSRRMT QDDWSRTHPD DIFSVIEKTL VEDGYKWNGV
     KPGHCDWGKL KESGAIDNFR GTLEGELGKN CDLTCNAAAV KLDTLQKVKM SSDWTARVGI
     VLGAPGVGKS TSIKNLLDKF GAKHKMVLCL PFSQLLEGVF AGRLDTFLVD DLFCRSVGYG
     KYNTMLVDEV TRVHMCEILV LAGHLGVKNV ICFGDPAQGL NYKAGSAVNY NFPIIAECYA
     SRRFGKATAD LINSSNGGGK PVVGNNEVKD SWTFEELCGK ILDMSTVLVA TRETQKFLLE
     DNIESILYSD AHGQTYDVVT IILEDEFDDA AICDPNVRAV LLTRARKGGM IKMGPNIAAR
     FKNGDFNSRG VSKSCTGDTF CEDR