TGB1_ICRSV
ID TGB1_ICRSV Reviewed; 225 AA.
AC Q918W2;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 29-SEP-2021, entry version 57.
DE RecName: Full=Movement and silencing protein TGBp1;
DE AltName: Full=25 kDa protein;
DE AltName: Full=Silencing suppressor P25;
DE AltName: Full=Triple gene block 1 protein;
DE Short=TGBp1;
GN ORFNames=ORF2;
OS Indian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996)
OS (ICRSV).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Tymovirales; Alphaflexiviridae; Potexvirus; Mandarivirus.
OX NCBI_TaxID=651357;
OH NCBI_TaxID=2706; Citrus.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=11043949; DOI=10.1007/s007050070064;
RA Rustici G., Accotto G.P., Noris E., Masenga V., Luisoni E., Milne R.G.;
RT "Indian citrus ringspot virus: a proposed new species with some affinities
RT to potex-, carla-, fovea- and allexiviruses.";
RL Arch. Virol. 145:1895-1908(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=12417955; DOI=10.1007/s00705-002-0875-6;
RA Rustici G., Milne R.G., Accotto G.P.;
RT "Nucleotide sequence, genome organisation and phylogenetic analysis of
RT Indian citrus ringspot virus.";
RL Arch. Virol. 147:2215-2224(2002).
CC -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC through plasmosdesmata, without any budding. The movement protein
CC allows efficient cell to cell propagation, by bypassing the host cell
CC wall barrier. Increases plasmodesma size exclusion limit. Acts as a
CC suppressor of RNA-mediated gene silencing, also known as post-
CC transcriptional gene silencing (PTGS), a mechanism of plant viral
CC defense that limits the accumulation of viral RNAs (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer and homooligomer. Interacts with capsid protein.
CC Interacts with host AGO1; this interaction targets the host protein for
CC degradation, thereby suppressing the antiviral RNA silencing (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC cell propagation. TGBp1 is the main movement protein that physically
CC cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC facilitate TGBp1 function.
CC -!- SIMILARITY: Belongs to the Tymovirales TGBp1 protein family.
CC {ECO:0000305}.
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DR EMBL; AF406744; AAK97523.1; -; Genomic_RNA.
DR RefSeq; NP_203554.1; NC_003093.1.
DR GeneID; 922108; -.
DR KEGG; vg:922108; -.
DR Proteomes; UP000000394; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR Pfam; PF01443; Viral_helicase1; 1.
DR PROSITE; PS51657; PSRV_HELICASE; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host-virus interaction; Reference proteome; RNA-binding;
KW Suppressor of RNA silencing; Transport; Viral movement protein.
FT CHAIN 1..225
FT /note="Movement and silencing protein TGBp1"
FT /id="PRO_0000401079"
FT DOMAIN 1..110
FT /note="(+)RNA virus helicase ATP-binding"
FT DOMAIN 111..225
FT /note="(+)RNA virus helicase C-terminal"
SQ SEQUENCE 225 AA; 24954 MW; EFBB309C3032DCA7 CRC64;
MDFAELLESK AFTRTRLPLS KPIVVHAVAG AGKTSLLENY ARINPAARIY TPIAQQSNSL
LLSPFTQSLE QADIVDEYPL STLHPGVEYV LADPIQYLGS KDLLKPHYIC PTTHRFGHST
AEFLTSLGIE TYAHKPDRLT IANIFKTEPH GQVIACDLDT QQLAARHSLD YLRPCQSIGK
TFKDTTILIS HELNRDTLTK EIYIALTRHT NSVTILTPDA PSTSS