TGB1_LOLV
ID TGB1_LOLV Reviewed; 268 AA.
AC B1PS77;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 07-OCT-2020, entry version 35.
DE RecName: Full=Movement and silencing protein TGBp1;
DE AltName: Full=25 kDa protein;
DE AltName: Full=Silencing suppressor P25;
DE AltName: Full=Triple gene block 1 protein;
DE Short=TGBp1;
GN Name=ORF2;
OS Lolium latent virus (isolate Lolium/USA/US1/-) (LoLV).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Tymovirales; Alphaflexiviridae; Lolavirus.
OX NCBI_TaxID=686945;
OH NCBI_TaxID=480553; Lolium multiflorum x Lolium perenne.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA Vaira A.M.V., Maroon-Lango C.J., Hammond J.;
RT "Molecular characterization of Lolium latent virus, proposed type member of
RT a new genus in the family Flexiviridae.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC through plasmosdesmata, without any budding. The movement protein
CC allows efficient cell to cell propagation, by bypassing the host cell
CC wall barrier. Increases plasmodesma size exclusion limit. Acts as a
CC suppressor of RNA-mediated gene silencing, also known as post-
CC transcriptional gene silencing (PTGS), a mechanism of plant viral
CC defense that limits the accumulation of viral RNAs (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer and homooligomer. Interacts with capsid protein.
CC Interacts with host AGO1; this interaction targets the host protein for
CC degradation, thereby suppressing the antiviral RNA silencing (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC cell propagation. TGBp1 is the main movement protein that physically
CC cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC facilitate TGBp1 function.
CC -!- SIMILARITY: Belongs to the Tymovirales TGBp1 protein family.
CC {ECO:0000305}.
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DR EMBL; EU489641; ACA53375.1; -; Genomic_RNA.
DR RefSeq; YP_001718500.1; NC_010434.1.
DR GeneID; 6000102; -.
DR KEGG; vg:6000102; -.
DR Proteomes; UP000008689; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01443; Viral_helicase1; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51657; PSRV_HELICASE; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host-virus interaction; Reference proteome; RNA-binding;
KW Suppressor of RNA silencing; Transport; Viral movement protein.
FT CHAIN 1..268
FT /note="Movement and silencing protein TGBp1"
FT /id="PRO_0000401074"
FT DOMAIN 1..138
FT /note="(+)RNA virus helicase ATP-binding"
FT DOMAIN 139..268
FT /note="(+)RNA virus helicase C-terminal"
SQ SEQUENCE 268 AA; 30474 MW; F3F9BB1979C6E4A7 CRC64;
MEDFFNCLRS RGFERTDEPL PSDSRRIVVH GVGGSGKTSL IEAFAIANEW VRAYTLTSHE
RFDISGRGIS QYKGQPIDEK LWTILDEYGQ TDNPETLPPF NVLATDPYQA FRCQPLRAHF
VSLRSYRVPH HIAQAITQYT GFPIEAAGTD LHEGKYTVGP WTDKLRQQIL VEDGEIHYQL
SRRQCPHKLI TDAIGEQWPT VTVVFDRSIS PESARPLRCL FYIAATRSSN ELNIRTYVPT
RTPGLIKASL PHTSCRLCCR PRDLPSEN