TGB1_LSV
ID TGB1_LSV Reviewed; 228 AA.
AC P27330;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 23-FEB-2022, entry version 63.
DE RecName: Full=Movement and silencing protein TGBp1;
DE AltName: Full=25 kDa protein;
DE AltName: Full=Silencing suppressor P25;
DE AltName: Full=Triple gene block 1 protein;
DE Short=TGBp1;
GN ORFNames=ORF2;
OS Lily symptomless virus (LSV).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Tymovirales; Betaflexiviridae; Quinvirinae; Carlavirus.
OX NCBI_TaxID=12173;
OH NCBI_TaxID=4688; Lilium.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=2129538; DOI=10.1099/0022-1317-71-4-917;
RA Memelink J., van der Vlugt C.I.M., Linthorst H.J.M., Derks A.F.L.M.,
RA Asjes C.J., Bol J.F.;
RT "Homologies between the genomes of a carlavirus (lily symptomless virus)
RT and a potexvirus (lily virus X) from lily plants.";
RL J. Gen. Virol. 71:917-924(1990).
CC -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC through plasmosdesmata, without any budding. The movement protein
CC allows efficient cell to cell propagation, by bypassing the host cell
CC wall barrier. Increases plasmodesma size exclusion limit. Acts as a
CC suppressor of RNA-mediated gene silencing, also known as post-
CC transcriptional gene silencing (PTGS), a mechanism of plant viral
CC defense that limits the accumulation of viral RNAs (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer and homooligomer. Interacts with capsid protein.
CC Interacts with host AGO1; this interaction targets the host protein for
CC degradation, thereby suppressing the antiviral RNA silencing (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC cell propagation. TGBp1 is the main movement protein that physically
CC cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC facilitate TGBp1 function.
CC -!- SIMILARITY: Belongs to the Tymovirales TGBp1 protein family.
CC {ECO:0000305}.
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DR EMBL; X15343; CAA33398.1; -; Genomic_RNA.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR Pfam; PF01443; Viral_helicase1; 1.
DR PROSITE; PS51657; PSRV_HELICASE; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host-virus interaction; RNA-binding;
KW Suppressor of RNA silencing; Transport; Viral movement protein.
FT CHAIN 1..228
FT /note="Movement and silencing protein TGBp1"
FT /id="PRO_0000222578"
FT DOMAIN 1..132
FT /note="(+)RNA virus helicase ATP-binding"
FT DOMAIN 133..228
FT /note="(+)RNA virus helicase C-terminal"
SQ SEQUENCE 228 AA; 25374 MW; C9962D4BB63CEA24 CRC64;
MDVLLSLLSE FGFERLSSEL SLPIVVHSVP GGGKSSLIRK LINKDRRFSA YTFGLEDCES
ITGVRIKKAH ASIPRSEFVV FDEYIEGDTP PWAFAVFADP LQGGPGPVLR AHFIKRRSHR
FGKCTAQLLN DLSYEVESDL ADVVQIQGLY ETDLQGTVVY YEACVGNLLR AHSVPAYYIS
EIRGQTFESV TFVTSENYPV DRALAFQCLT RHRSSLLILS PNATYTAS