ID   TGB1_LVX                Reviewed;         216 AA.
AC   P27329;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   23-FEB-2022, entry version 66.
DE   RecName: Full=Movement and silencing protein TGBp1;
DE   AltName: Full=25 kDa protein;
DE   AltName: Full=Silencing suppressor P25;
DE   AltName: Full=Triple gene block 1 protein;
DE            Short=TGBp1;
GN   ORFNames=ORF2;
OS   Lily virus X.
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Alphaflexiviridae; Potexvirus.
OX   NCBI_TaxID=12194;
OH   NCBI_TaxID=63788; Lilium formosanum.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2129538; DOI=10.1099/0022-1317-71-4-917;
RA   Memelink J., van der Vlugt C.I.M., Linthorst H.J.M., Derks A.F.L.M.,
RA   Asjes C.J., Bol J.F.;
RT   "Homologies between the genomes of a carlavirus (lily symptomless virus)
RT   and a potexvirus (lily virus X) from lily plants.";
RL   J. Gen. Virol. 71:917-924(1990).
RN   [2]
RP   REVIEW.
RX   PubMed=15828680; DOI=10.1094/mpmi-18-0283;
RA   Verchot-Lubicz J.;
RT   "A new cell-to-cell transport model for Potexviruses.";
RL   Mol. Plant Microbe Interact. 18:283-290(2005).
CC   -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC       through plasmosdesmata, without any budding. The movement protein
CC       allows efficient cell to cell propagation, by bypassing the host cell
CC       wall barrier. Increases plasmodesma size exclusion limit. Acts as a
CC       suppressor of RNA-mediated gene silencing, also known as post-
CC       transcriptional gene silencing (PTGS), a mechanism of plant viral
CC       defense that limits the accumulation of viral RNAs (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer and homooligomer. Interacts with capsid protein.
CC       Interacts with host AGO1; this interaction targets the host protein for
CC       degradation, thereby suppressing the antiviral RNA silencing (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC   -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC       cell propagation. TGBp1 is the main movement protein that physically
CC       cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC       facilitate TGBp1 function.
CC   -!- SIMILARITY: Belongs to the Tymovirales TGBp1 protein family.
CC       {ECO:0000305}.
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DR   EMBL; X15342; CAA33394.1; -; Genomic_RNA.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR   Pfam; PF01443; Viral_helicase1; 1.
DR   PROSITE; PS51657; PSRV_HELICASE; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction; RNA-binding;
KW   Suppressor of RNA silencing; Transport; Viral movement protein.
FT   CHAIN           1..216
FT                   /note="Movement and silencing protein TGBp1"
FT                   /id="PRO_0000222566"
FT   DOMAIN          1..110
FT                   /note="(+)RNA virus helicase ATP-binding"
FT   DOMAIN          111..216
FT                   /note="(+)RNA virus helicase C-terminal"
SQ   SEQUENCE   216 AA;  23575 MW;  301ABB63308DE30B CRC64;
     MEFCGGTLRT RFQRTSVPNS PVTVVHTVAG SGKTTFIRNL LIDHPQLVAR TYGTPDVPNL
     LGYGIRDRHG DAHIVDEYPA ADLRSHPSVS IVFADPLQHH GEVRPAHFTC SHTHRFGKST
     CSLLGTLGVY CTSDKEDSVT FAGAYLAEPV GTLIALGEDA ELVLDNHRVE YFTPCQALGL
     TFPSVTLLTD APIEDQPPVS RYIALTRHTD SLLILN