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TGB1_NMV
ID   TGB1_NMV                Reviewed;         233 AA.
AC   P15096;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   07-OCT-2020, entry version 77.
DE   RecName: Full=Movement and silencing protein TGBp1;
DE   AltName: Full=25 kDa protein;
DE   AltName: Full=Silencing suppressor P25;
DE   AltName: Full=Triple gene block 1 protein;
DE            Short=TGBp1;
GN   ORFNames=ORF2;
OS   Narcissus mosaic virus (NMV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Alphaflexiviridae; Potexvirus.
OX   NCBI_TaxID=12180;
OH   NCBI_TaxID=39639; Narcissus pseudonarcissus (Daffodil).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2732689; DOI=10.1099/0022-1317-70-2-267;
RA   Zuidema D., Linthorst H.J.M., Huisman M.J., Asjes C.J., Bol J.F.;
RT   "Nucleotide sequence of narcissus mosaic virus RNA.";
RL   J. Gen. Virol. 70:267-276(1989).
RN   [2]
RP   REVIEW.
RX   PubMed=15828680; DOI=10.1094/mpmi-18-0283;
RA   Verchot-Lubicz J.;
RT   "A new cell-to-cell transport model for Potexviruses.";
RL   Mol. Plant Microbe Interact. 18:283-290(2005).
CC   -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC       through plasmosdesmata, without any budding. The movement protein
CC       allows efficient cell to cell propagation, by bypassing the host cell
CC       wall barrier. Increases plasmodesma size exclusion limit. Acts as a
CC       suppressor of RNA-mediated gene silencing, also known as post-
CC       transcriptional gene silencing (PTGS), a mechanism of plant viral
CC       defense that limits the accumulation of viral RNAs (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer and homooligomer. Interacts with capsid protein.
CC       Interacts with host AGO1; this interaction targets the host protein for
CC       degradation, thereby suppressing the antiviral RNA silencing (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC   -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC       cell propagation. TGBp1 is the main movement protein that physically
CC       cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC       facilitate TGBp1 function.
CC   -!- SIMILARITY: Belongs to the Tymovirales TGBp1 protein family.
CC       {ECO:0000305}.
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DR   EMBL; D13747; BAA02892.1; -; Genomic_RNA.
DR   PIR; JT0471; WMWGN1.
DR   RefSeq; NP_040779.1; NC_001441.1.
DR   GeneID; 1494020; -.
DR   KEGG; vg:1494020; -.
DR   Proteomes; UP000008865; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01443; Viral_helicase1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51657; PSRV_HELICASE; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction; Reference proteome; RNA-binding;
KW   Suppressor of RNA silencing; Transport; Viral movement protein.
FT   CHAIN           1..233
FT                   /note="Movement and silencing protein TGBp1"
FT                   /id="PRO_0000222567"
FT   DOMAIN          1..134
FT                   /note="(+)RNA virus helicase ATP-binding"
FT   DOMAIN          135..233
FT                   /note="(+)RNA virus helicase C-terminal"
SQ   SEQUENCE   233 AA;  25846 MW;  E38ECBED863EFA7D CRC64;
     MDCKYLLELL DSYSFIRSSR SFSSPIIIHG VAGCGKSTII QKIALAFPEL LIGSFTPALL
     DSNSGRKQLA VTSDPLDILD EYLGGPNPVV RLAKFCDPLQ YSCEQPEVPH FTSLLTWRFC
     VRTTALLNGI FGCQIKSRRE DLCHLTHENP YTTDPKGVVV AHEQEVINLL LQHGCPVTPT
     QHLWGLTIPV VSVYITSIAS LSTVDRANLF LSLTRDSKAL HIFEFDAWSH ATC
 
 
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