TGB1_PMV
ID TGB1_PMV Reviewed; 233 AA.
AC P20952;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 23-FEB-2022, entry version 78.
DE RecName: Full=Movement and silencing protein TGBp1;
DE AltName: Full=25 kDa protein;
DE AltName: Full=Silencing suppressor P25;
DE AltName: Full=Triple gene block 1 protein;
DE Short=TGBp1;
GN ORFNames=ORF2;
OS Papaya mosaic potexvirus (PMV).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Tymovirales; Alphaflexiviridae; Potexvirus.
OX NCBI_TaxID=12181;
OH NCBI_TaxID=3649; Carica papaya (Papaya).
OH NCBI_TaxID=108055; Ullucus tuberosus (Olluco).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=2778435; DOI=10.1099/0022-1317-70-9-2325;
RA Sit T.L., Abouhaidar M.G., Holy S.;
RT "Nucleotide sequence of papaya mosaic virus RNA.";
RL J. Gen. Virol. 70:2325-2331(1989).
RN [2]
RP REVIEW.
RX PubMed=15828680; DOI=10.1094/mpmi-18-0283;
RA Verchot-Lubicz J.;
RT "A new cell-to-cell transport model for Potexviruses.";
RL Mol. Plant Microbe Interact. 18:283-290(2005).
CC -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC through plasmosdesmata, without any budding. The movement protein
CC allows efficient cell to cell propagation, by bypassing the host cell
CC wall barrier. Increases plasmodesma size exclusion limit. Acts as a
CC suppressor of RNA-mediated gene silencing, also known as post-
CC transcriptional gene silencing (PTGS), a mechanism of plant viral
CC defense that limits the accumulation of viral RNAs (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer and homooligomer. Interacts with capsid protein.
CC Interacts with host AGO1; this interaction targets the host protein for
CC degradation, thereby suppressing the antiviral RNA silencing (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC cell propagation. TGBp1 is the main movement protein that physically
CC cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC facilitate TGBp1 function.
CC -!- SIMILARITY: Belongs to the Tymovirales TGBp1 protein family.
CC {ECO:0000305}.
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DR EMBL; D13957; BAA03051.1; -; Genomic_RNA.
DR PIR; JQ0097; JQ0097.
DR RefSeq; NP_044331.1; NC_001748.1.
DR GeneID; 1494024; -.
DR KEGG; vg:1494024; -.
DR Proteomes; UP000000477; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR Pfam; PF01443; Viral_helicase1; 1.
DR PROSITE; PS51657; PSRV_HELICASE; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host-virus interaction; Reference proteome; RNA-binding;
KW Suppressor of RNA silencing; Transport; Viral movement protein.
FT CHAIN 1..233
FT /note="Movement and silencing protein TGBp1"
FT /id="PRO_0000222569"
FT DOMAIN 1..133
FT /note="(+)RNA virus helicase ATP-binding"
FT DOMAIN 134..233
FT /note="(+)RNA virus helicase C-terminal"
SQ SEQUENCE 233 AA; 26250 MW; C5B3777B9328B554 CRC64;
MNHFINLLVA EGFVRTNEPL TDQLVVHSVA GSGKSTLIRK FLEEQPLARA YTHCRADPPN
LEGRFIQPFK GPCPDHFNIL DEYCKEPISA KFQVLIADPL QYRTQHLRPH YVNHKSHRLG
PETCKLLSSL GIKVESHRRD RDVVTLSGIF GSPILGQAIA LDRSASDLLR AHGIQALCPI
ESIGQEYPVV TVVSSEPLRN VRFKDQVYIA LSRHTEQLHV LSPEFPHTTS RPQ
