TGB1_SHVX
ID TGB1_SHVX Reviewed; 241 AA.
AC Q04581;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 29-SEP-2021, entry version 77.
DE RecName: Full=Movement and silencing protein TGBp1;
DE AltName: Full=25 kDa protein;
DE AltName: Full=Silencing suppressor P25;
DE AltName: Full=Triple gene block 1 protein;
DE Short=TGBp1;
GN ORFNames=ORF2;
OS Shallot virus X (ShVX).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Tymovirales; Alphaflexiviridae; Allexivirus; Acarallexivirus.
OX NCBI_TaxID=31770;
OH NCBI_TaxID=28911; Allium cepa var. aggregatum (Shallot) (Allium ascalonicum).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=1339468; DOI=10.1099/0022-1317-73-10-2553;
RA Kanyuka K.V., Vishnichenko V.K., Levay K.E., Kondrikov D.Y., Ryabov E.V.,
RA Zavriev S.K.;
RT "Nucleotide sequence of shallot virus X RNA reveals a 5'-proximal cistron
RT closely related to those of potexviruses and a unique arrangement of the
RT 3'-proximal cistrons.";
RL J. Gen. Virol. 73:2553-2560(1992).
CC -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC through plasmosdesmata, without any budding. The movement protein
CC allows efficient cell to cell propagation, by bypassing the host cell
CC wall barrier. Increases plasmodesma size exclusion limit. Acts as a
CC suppressor of RNA-mediated gene silencing, also known as post-
CC transcriptional gene silencing (PTGS), a mechanism of plant viral
CC defense that limits the accumulation of viral RNAs (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer and homooligomer. Interacts with capsid protein.
CC Interacts with host AGO1; this interaction targets the host protein for
CC degradation, thereby suppressing the antiviral RNA silencing (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC cell propagation. TGBp1 is the main movement protein that physically
CC cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC facilitate TGBp1 function.
CC -!- SIMILARITY: Belongs to the Tymovirales TGBp1 protein family.
CC {ECO:0000305}.
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DR EMBL; M97264; AAA47788.1; -; Genomic_RNA.
DR PIR; JQ1735; JQ1735.
DR RefSeq; NP_620649.1; NC_003795.1.
DR GeneID; 944365; -.
DR KEGG; vg:944365; -.
DR Proteomes; UP000001663; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01443; Viral_helicase1; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS51657; PSRV_HELICASE; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host-virus interaction; Reference proteome; RNA-binding;
KW Suppressor of RNA silencing; Transport; Viral movement protein.
FT CHAIN 1..241
FT /note="Movement and silencing protein TGBp1"
FT /id="PRO_0000222582"
FT DOMAIN 1..133
FT /note="(+)RNA virus helicase ATP-binding"
FT DOMAIN 134..241
FT /note="(+)RNA virus helicase C-terminal"
SQ SEQUENCE 241 AA; 26334 MW; CF9E48B86C051278 CRC64;
MKTDLLLQIL SNNNFTRTSE PIKEPLIIHG VPGSGKSTLV RALVTYRSTV ACTLGAPYGS
NLAFPGVTSP GLTQSLTDHE TRILDEYQLG TESDLKPFNV LVGDPFQGNL HLKAHYVKSF
SHRVPRIICN FLQSLGYEIA GSKPGELAQL PIYGPNPSGP TGQVLHLGPL SRRLTQSHGV
CSKLPSEVQG LEFEEVTLVY HSSEFERNRV GFYIAATRAL GRLNLITDTT LEIPHELCPT
S
