TGB1_SMYEA
ID TGB1_SMYEA Reviewed; 229 AA.
AC Q00846;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 2.
DT 23-FEB-2022, entry version 78.
DE RecName: Full=Movement and silencing protein TGBp1;
DE AltName: Full=25 kDa protein;
DE AltName: Full=Silencing suppressor P25;
DE AltName: Full=Triple gene block 1 protein;
DE Short=TGBp1;
GN ORFNames=ORF2;
OS Strawberry mild yellow edge-associated virus (SMYEaV).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Tymovirales; Alphaflexiviridae; Potexvirus.
OX NCBI_TaxID=12187;
OH NCBI_TaxID=63459; Chenopodium quinoa (Quinoa).
OH NCBI_TaxID=57918; Fragaria vesca (Woodland strawberry) (Potentilla vesca).
OH NCBI_TaxID=59498; Rubus rosifolius.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=MY-18;
RX PubMed=1339469; DOI=10.1099/0022-1317-73-2-475;
RA Jelkmann W., Maiss E., Martin R.R.;
RT "The nucleotide sequence and genome organization of strawberry mild yellow
RT edge-associated potexvirus.";
RL J. Gen. Virol. 73:475-479(1992).
RN [2]
RP REVIEW.
RX PubMed=15828680; DOI=10.1094/mpmi-18-0283;
RA Verchot-Lubicz J.;
RT "A new cell-to-cell transport model for Potexviruses.";
RL Mol. Plant Microbe Interact. 18:283-290(2005).
CC -!- FUNCTION: Transports viral genome to neighboring plant cells directly
CC through plasmosdesmata, without any budding. The movement protein
CC allows efficient cell to cell propagation, by bypassing the host cell
CC wall barrier. Increases plasmodesma size exclusion limit. Acts as a
CC suppressor of RNA-mediated gene silencing, also known as post-
CC transcriptional gene silencing (PTGS), a mechanism of plant viral
CC defense that limits the accumulation of viral RNAs (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer and homooligomer. Interacts with capsid protein.
CC Interacts with host AGO1; this interaction targets the host protein for
CC degradation, thereby suppressing the antiviral RNA silencing (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC cell propagation. TGBp1 is the main movement protein that physically
CC cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC facilitate TGBp1 function.
CC -!- SIMILARITY: Belongs to the Tymovirales TGBp1 protein family.
CC {ECO:0000305}.
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DR EMBL; D12517; BAA02083.2; -; Genomic_RNA.
DR PIR; JQ1427; JQ1427.
DR RefSeq; NP_620643.1; NC_003794.1.
DR GeneID; 944376; -.
DR KEGG; vg:944376; -.
DR Proteomes; UP000007225; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR Pfam; PF01443; Viral_helicase1; 1.
DR PROSITE; PS51657; PSRV_HELICASE; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host-virus interaction; Reference proteome; RNA-binding;
KW Suppressor of RNA silencing; Transport; Viral movement protein.
FT CHAIN 1..229
FT /note="Movement and silencing protein TGBp1"
FT /id="PRO_0000222574"
FT DOMAIN 1..114
FT /note="(+)RNA virus helicase ATP-binding"
FT DOMAIN 115..229
FT /note="(+)RNA virus helicase C-terminal"
SQ SEQUENCE 229 AA; 25391 MW; 215B94902BD4D491 CRC64;
MVEFTKRLLL ERNFERTNRP ITGPIVVHAV AGAGKSSVIN TVSLTFQLIC WTTLPEEKAS
FNCLHLRHLD GPAFPGAFVD EYQLADTDLS EAAFLFGDPL QYPGPAAQVP HFVKLFSHRC
GLNSASLIRE LGIAFEASKL DSVQHLDPYS SDPEGTILAF EPEVQAALAS HSLDFLCLDE
FRGKQWPVCT LYVSTKNLCD LDRPSVYVAL TRHYERLLIM SFDAADTSA
