ID   TGB2_ASPVP              Reviewed;         120 AA.
AC   Q64964;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 49.
DE   RecName: Full=Movement protein TGB2;
DE   AltName: Full=Triple gene block 2 protein;
DE            Short=TGBp2;
GN   ORFNames=ORF3;
OS   Apple stem pitting virus (isolate PA66) (ASPV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Betaflexiviridae; Quinvirinae; Foveavirus.
OX   NCBI_TaxID=651356;
OH   NCBI_TaxID=23159; Crataegus (hawthorn).
OH   NCBI_TaxID=106566; Malus sieboldii.
OH   NCBI_TaxID=3752; Malus sylvestris.
OH   NCBI_TaxID=23211; Pyrus communis (Pear) (Pyrus domestica).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8021584; DOI=10.1099/0022-1317-75-7-1535;
RA   Jelkmann W.;
RT   "Nucleotide sequences of apple stem pitting virus and of the coat protein
RT   gene of a similar virus from pear associated with vein yellows disease and
RT   their relationship with potex- and carlaviruses.";
RL   J. Gen. Virol. 75:1535-1542(1994).
CC   -!- FUNCTION: Plays a role in viral cell-to-cell propagation, by
CC       facilitating genome transport to neighboring plant cells through
CC       plasmosdesmata,. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC       cell propagation. TGBp1 is the main movement protein that physically
CC       cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC       facilitate TGBp1 function.
CC   -!- SIMILARITY: Belongs to the Tymovirales TGBp2 protein family.
CC       {ECO:0000305}.
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DR   EMBL; D21829; BAA04855.1; -; Genomic_RNA.
DR   RefSeq; NP_604466.1; NC_003462.2.
DR   GeneID; 935271; -.
DR   KEGG; vg:935271; -.
DR   Proteomes; UP000000678; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001896; Plant_vir_prot.
DR   Pfam; PF01307; Plant_vir_prot; 1.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Viral movement protein.
FT   CHAIN           1..120
FT                   /note="Movement protein TGB2"
FT                   /id="PRO_0000401091"
FT   TOPO_DOM        1..8
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..71
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93..120
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   120 AA;  12847 MW;  63EAE58EEDEA94F8 CRC64;
     MPFAQPPDYS KSVFPIAVGI AVAVVLFTLT RSTLPQVGDN IHNLPHGGNY QDGTKRISYC
     GPRDSFPSSS LISSGTPMII GIIIFLIFAI YVSEKWSRSG SRRCSCCVPG APACTATVHE