ID   TGB2_PVMR               Reviewed;         109 AA.
AC   P17527;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   07-OCT-2020, entry version 79.
DE   RecName: Full=Movement protein TGB2;
DE   AltName: Full=12 kDa protein;
DE   AltName: Full=Triple gene block 2 protein;
DE            Short=TGBp2;
GN   ORFNames=ORF3;
OS   Potato virus M (strain Russian) (PVM).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Betaflexiviridae; Quinvirinae; Carlavirus.
OX   NCBI_TaxID=12168;
OH   NCBI_TaxID=4113; Solanum tuberosum (Potato).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2738581; DOI=10.1099/0022-1317-70-7-1861;
RA   Rupasov V.V., Morozov S.Y., Kanyuka K.V., Zavriev S.K.;
RT   "Partial nucleotide sequence of potato virus M RNA shows similarities to
RT   protexviruses in gene arrangement and the encoded amino acid sequences.";
RL   J. Gen. Virol. 70:1861-1869(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1990070; DOI=10.1099/0022-1317-72-1-9;
RA   Zavriev S.K., Kanyuka K.V., Levay K.E.;
RT   "The genome organization of potato virus M RNA.";
RL   J. Gen. Virol. 72:9-14(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1944258;
RA   Zavriev S.K., Kaniuka K.V., Levai K.E.;
RT   "Complete nucleotide sequence of genomic RNA of the potato M-virus.";
RL   Mol. Biol. (Mosk.) 25:761-769(1991).
CC   -!- FUNCTION: Plays a role in viral cell-to-cell propagation, by
CC       facilitating genome transport to neighboring plant cells through
CC       plasmosdesmata,. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC       cell propagation. TGBp1 is the main movement protein that physically
CC       cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC       facilitate TGBp1 function.
CC   -!- SIMILARITY: Belongs to the Tymovirales TGBp2 protein family.
CC       {ECO:0000305}.
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DR   EMBL; D14449; BAA03341.1; -; Genomic_RNA.
DR   PIR; PN0003; WMVYP2.
DR   RefSeq; NP_056769.1; NC_001361.2.
DR   GeneID; 1493990; -.
DR   KEGG; vg:1493990; -.
DR   Proteomes; UP000000677; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001896; Plant_vir_prot.
DR   Pfam; PF01307; Plant_vir_prot; 1.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Viral movement protein.
FT   CHAIN           1..109
FT                   /note="Movement protein TGB2"
FT                   /id="PRO_0000222599"
FT   TOPO_DOM        1..9
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..72
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..109
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   109 AA;  11907 MW;  F31D213AA67CD1AA CRC64;
     MPLTPPPDFT KVYLSAALGV SLALVVWLLI RSTLPVVGDR DHNLPHGGWY RDGTKSVFYN
     SPGRLNSIEA RKAPLLGQPW AIVVLLVLLI WASHKLGRPN CRACAGSHT