ID   TGB2_PVXX3              Reviewed;         115 AA.
AC   P0C786; P07697;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   07-OCT-2020, entry version 23.
DE   RecName: Full=Movement protein TGB2;
DE   AltName: Full=12 kDa protein;
DE   AltName: Full=Triple gene block 2 protein;
DE            Short=TGBp2;
GN   ORFNames=ORF3;
OS   Potato virus X (strain X3) (PVX).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Alphaflexiviridae; Potexvirus.
OX   NCBI_TaxID=12185;
OH   NCBI_TaxID=3711; Brassica campestris (Field mustard).
OH   NCBI_TaxID=4113; Solanum tuberosum (Potato).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3404114; DOI=10.1099/0022-1317-69-8-1789;
RA   Huisman M.J., Linthorst H.J.M., Bol J.F., Cornelissen B.J.C.;
RT   "The complete nucleotide sequence of potato virus X and its homologies at
RT   the amino acid level with various plus-stranded RNA viruses.";
RL   J. Gen. Virol. 69:1789-1798(1988).
RN   [2]
RP   FUNCTION.
RX   PubMed=12890619; DOI=10.1016/s0042-6822(03)00180-6;
RA   Mitra R., Krishnamurthy K., Blancaflor E., Payton M., Nelson R.S.,
RA   Verchot-Lubicz J.;
RT   "The potato virus X TGBp2 protein association with the endoplasmic
RT   reticulum plays a role in but is not sufficient for viral cell-to-cell
RT   movement.";
RL   Virology 312:35-48(2003).
RN   [3]
RP   FUNCTION.
RX   PubMed=16055678; DOI=10.1104/pp.105.066019;
RA   Ju H.J., Samuels T.D., Wang Y.S., Blancaflor E., Payton M., Mitra R.,
RA   Krishnamurthy K., Nelson R.S., Verchot-Lubicz J.;
RT   "The potato virus X TGBp2 movement protein associates with endoplasmic
RT   reticulum-derived vesicles during virus infection.";
RL   Plant Physiol. 138:1877-1895(2005).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=17610926; DOI=10.1016/j.virol.2007.05.022;
RA   Samuels T.D., Ju H.J., Ye C.M., Motes C.M., Blancaflor E.B.,
RA   Verchot-Lubicz J.;
RT   "Subcellular targeting and interactions among the Potato virus X TGB
RT   proteins.";
RL   Virology 367:375-389(2007).
CC   -!- FUNCTION: Plays a role in viral cell-to-cell propagation, by
CC       facilitating genome transport to neighboring plant cells through
CC       plasmosdesmata,. {ECO:0000269|PubMed:12890619,
CC       ECO:0000269|PubMed:16055678}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:17610926}.
CC   -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC       cell propagation. TGBp1 is the main movement protein that physically
CC       cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC       facilitate TGBp1 function.
CC   -!- SIMILARITY: Belongs to the Tymovirales TGBp2 protein family.
CC       {ECO:0000305}.
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DR   EMBL; D00344; BAA00251.1; -; Genomic_RNA.
DR   PIR; JA0104; WMWGP3.
DR   RefSeq; YP_002332931.1; NC_011620.1.
DR   GeneID; 7065756; -.
DR   KEGG; vg:7065756; -.
DR   Proteomes; UP000008687; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001896; Plant_vir_prot.
DR   Pfam; PF01307; Plant_vir_prot; 1.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Viral movement protein.
FT   CHAIN           1..115
FT                   /note="Movement protein TGB2"
FT                   /id="PRO_0000399907"
FT   TOPO_DOM        1..13
FT                   /note="Cytoplasmic"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        35..74
FT                   /note="Lumenal"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        96..115
FT                   /note="Cytoplasmic"
SQ   SEQUENCE   115 AA;  12338 MW;  029983C61B842C0D CRC64;
     MSAQGHRLTA PVNSEKVYIV LGLSFALVSI TFLLSRNSLP HVGDNIHSLP HGGAYRDGTK
     AILYNSPNLG SRVSLHNGKN AAFAAVLLLT LLIYGSKYIS QRNHTCACGN NHSSH