ID   TGB3_ASPVP              Reviewed;          70 AA.
AC   Q64965;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 50.
DE   RecName: Full=Movement protein TGBp3;
DE   AltName: Full=Triple gene block 3 protein;
DE            Short=TGBp3;
GN   ORFNames=ORF4;
OS   Apple stem pitting virus (isolate PA66) (ASPV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Betaflexiviridae; Quinvirinae; Foveavirus.
OX   NCBI_TaxID=651356;
OH   NCBI_TaxID=23159; Crataegus (hawthorn).
OH   NCBI_TaxID=106566; Malus sieboldii.
OH   NCBI_TaxID=3752; Malus sylvestris.
OH   NCBI_TaxID=23211; Pyrus communis (Pear) (Pyrus domestica).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8021584; DOI=10.1099/0022-1317-75-7-1535;
RA   Jelkmann W.;
RT   "Nucleotide sequences of apple stem pitting virus and of the coat protein
RT   gene of a similar virus from pear associated with vein yellows disease and
RT   their relationship with potex- and carlaviruses.";
RL   J. Gen. Virol. 75:1535-1542(1994).
CC   -!- FUNCTION: Plays a role in viral cell-to-cell propagation, by
CC       facilitating genome transport to neighboring plant cells through
CC       plasmosdesmata. May induce the formation of granular vesicles derived
CC       from the Endoplasmic reticulum, which align on actin filaments (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC       cell propagation. TGBp1 is the main movement protein that physically
CC       cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC       facilitate TGBp1 function.
CC   -!- SIMILARITY: Belongs to the Tymovirales TGBp3 protein family.
CC       {ECO:0000305}.
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DR   EMBL; D21829; BAA04856.1; -; Genomic_RNA.
DR   RefSeq; NP_604467.1; NC_003462.2.
DR   GeneID; 935272; -.
DR   KEGG; vg:935272; -.
DR   Proteomes; UP000000678; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR003411; TGBp3.
DR   Pfam; PF02495; TGBp3; 1.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Viral movement protein.
FT   CHAIN           1..70
FT                   /note="Movement protein TGBp3"
FT                   /id="PRO_0000401092"
FT   TOPO_DOM        1..4
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        26..70
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   70 AA;  7438 MW;  3EE5B29A01E84459 CRC64;
     MFPRSGLGLA VAAAVVAYLV LLLAQQLYMS NSSQCTIVIT GESVSVVGCV YSEAFIELVK
     GLKPYYHPLG