ID   TGB3_CYMV               Reviewed;          59 AA.
AC   P16483;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   07-OCT-2020, entry version 67.
DE   RecName: Full=Movement protein TGBp3;
DE   AltName: Full=7 kDa protein;
DE   AltName: Full=Triple gene block 3 protein;
DE            Short=TGBp3;
GN   ORFNames=ORF4;
OS   Clover yellow mosaic virus (CYMV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Alphaflexiviridae; Potexvirus.
OX   NCBI_TaxID=12177;
OH   NCBI_TaxID=3559; Chenopodium album (Fat-hen).
OH   NCBI_TaxID=283210; Malus pumila (Paradise apple).
OH   NCBI_TaxID=3879; Medicago sativa (Alfalfa).
OH   NCBI_TaxID=3888; Pisum sativum (Garden pea).
OH   NCBI_TaxID=13274; Stellaria media (Common chickweed) (Alsine media).
OH   NCBI_TaxID=3898; Trifolium.
OH   NCBI_TaxID=3908; Vicia sativa (Spring vetch) (Tare).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2738582; DOI=10.1099/0022-1317-70-7-1871;
RA   Abouhaidar M.G., Lai R.;
RT   "Nucleotide sequence of the 3'-terminal region of clover yellow mosaic
RT   virus RNA.";
RL   J. Gen. Virol. 70:1871-1875(1989).
RN   [2]
RP   REVIEW.
RX   PubMed=15828680; DOI=10.1094/mpmi-18-0283;
RA   Verchot-Lubicz J.;
RT   "A new cell-to-cell transport model for Potexviruses.";
RL   Mol. Plant Microbe Interact. 18:283-290(2005).
CC   -!- FUNCTION: Plays a role in viral cell-to-cell propagation, by
CC       facilitating genome transport to neighboring plant cells through
CC       plasmosdesmata. May induce the formation of granular vesicles derived
CC       from the Endoplasmic reticulum, which align on actin filaments (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC       cell propagation. TGBp1 is the main movement protein that physically
CC       cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC       facilitate TGBp1 function.
CC   -!- SIMILARITY: Belongs to the Tymovirales TGBp3 protein family.
CC       {ECO:0000305}.
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DR   EMBL; D00485; BAA00372.1; -; Genomic_RNA.
DR   PIR; JU0402; JU0402.
DR   RefSeq; NP_077082.1; NC_001753.1.
DR   GeneID; 1494005; -.
DR   KEGG; vg:1494005; -.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR003411; TGBp3.
DR   Pfam; PF02495; TGBp3; 1.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport; Viral movement protein.
FT   CHAIN           1..59
FT                   /note="Movement protein TGBp3"
FT                   /id="PRO_0000222601"
FT   TOPO_DOM        1..3
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        4..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..59
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   59 AA;  6471 MW;  38F21FCF669229C4 CRC64;
     MHLAIVGALT LVLTLFVLHY TTKDDRCYIL INGHSAFTNC PASPDLAKVI SQLKPHNHG