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TGB3_PCV87
ID   TGB3_PCV87              Reviewed;         153 AA.
AC   Q08552;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 50.
DE   RecName: Full=Movement protein TGB3;
DE   AltName: Full=P17;
DE   AltName: Full=Triple gene block 3 protein;
DE            Short=TGBp3;
OS   Peanut clump virus (isolate 87/TGTA2) (PCV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Martellivirales; Virgaviridae; Pecluvirus.
OX   NCBI_TaxID=652837;
OH   NCBI_TaxID=3818; Arachis hypogaea (Peanut).
OH   NCBI_TaxID=4555; Setaria italica (Foxtail millet) (Panicum italicum).
OH   NCBI_TaxID=91525; Sorghum arundinaceum.
OH   NCBI_TaxID=4558; Sorghum bicolor (Sorghum) (Sorghum vulgare).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8317107; DOI=10.1006/viro.1993.1343;
RA   Manohar S.K., Guilley H., Dollet M., Richards K., Jonard G.;
RT   "Nucleotide sequence and genetic organization of peanut clump virus RNA 2
RT   and partial characterization of deleted forms.";
RL   Virology 195:33-41(1993).
RN   [2]
RP   FUNCTION.
RX   PubMed=9721240; DOI=10.1006/viro.1998.9287;
RA   Herzog E., Hemmer O., Hauser S., Meyer G., Bouzoubaa S., Fritsch C.;
RT   "Identification of genes involved in replication and movement of peanut
RT   clump virus.";
RL   Virology 248:312-322(1998).
CC   -!- FUNCTION: Participates in the transport of viral genome to neighboring
CC       plant cells directly through plasmodesmata, without any budding. TGBp2
CC       and TGBp3 are necessary for intracellular delivery of TGBp1-containing
CC       vRNPs to plasmodesmata. Can gate plasmodesmata and increase their size
CC       exclusion limit. Induces host actin cytoskeleton network thickening,
CC       which probably plays a major role in virus cell-to-cell movement.
CC       {ECO:0000250|UniProtKB:P04868}.
CC   -!- SUBUNIT: Interacts with movement proteins TGB1 and TGB2. TGB1-TGB3-TGB2
CC       complex formation is enhanced by ATP hydrolysis.
CC       {ECO:0000250|UniProtKB:P04868}.
CC   -!- SUBCELLULAR LOCATION: Host cell junction, host plasmodesma
CC       {ECO:0000250|UniProtKB:P04868}. Host endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:P04868}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9IV52}. Host cytoplasm, host cytoskeleton
CC       {ECO:0000250|UniProtKB:P04868}. Note=Probably localizes to
CC       plasmodesmata-associated membrane compartments called peripheral
CC       membrane bodies (PMBs). Associates with host actin filaments.
CC       {ECO:0000250|UniProtKB:P04868}.
CC   -!- DOMAIN: The 2nd transmembrane domain is involved in plasmodesmata
CC       targeting. {ECO:0000250|UniProtKB:Q9IV52}.
CC   -!- SIMILARITY: Belongs to the virgaviridae TGB3 movement protein family.
CC       {ECO:0000305}.
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DR   EMBL; L07269; AAA17440.1; -; Unassigned_DNA.
DR   RefSeq; NP_620032.1; NC_003668.1.
DR   SMR; Q08552; -.
DR   GeneID; 991037; -.
DR   KEGG; vg:991037; -.
DR   Proteomes; UP000001668; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR007617; Viral_beta_CD.
DR   Pfam; PF04530; Viral_Beta_CD; 1.
PE   3: Inferred from homology;
KW   Host cell junction; Host cytoplasm; Host cytoskeleton;
KW   Host endoplasmic reticulum; Host membrane; Membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW   Viral movement protein.
FT   CHAIN           1..153
FT                   /note="Movement protein TGB3"
FT                   /id="PRO_0000409151"
FT   TOPO_DOM        1..50
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9IV52"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q9IV52"
FT   TOPO_DOM        72..127
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q9IV52"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q9IV52"
FT   TOPO_DOM        149..153
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9IV52"
SQ   SEQUENCE   153 AA;  16830 MW;  CEBD13C014273DB1 CRC64;
     MEAPAITHSS GCVCSDCQWS GSPTVDTKVY LGSGTHANTT KTRETSFLSV LNDNAWLFVI
     AALILCLYFI ISKPHVDAVY TEFHQDLNGF SMKLAPGVPI DPKVIAAVKN WQKYPFGTDP
     RENMVTSIVS GLRHSFCILL LVVVLLVYVC HKP
 
 
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