TGB3_PCV87
ID TGB3_PCV87 Reviewed; 153 AA.
AC Q08552;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 23-FEB-2022, entry version 50.
DE RecName: Full=Movement protein TGB3;
DE AltName: Full=P17;
DE AltName: Full=Triple gene block 3 protein;
DE Short=TGBp3;
OS Peanut clump virus (isolate 87/TGTA2) (PCV).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Martellivirales; Virgaviridae; Pecluvirus.
OX NCBI_TaxID=652837;
OH NCBI_TaxID=3818; Arachis hypogaea (Peanut).
OH NCBI_TaxID=4555; Setaria italica (Foxtail millet) (Panicum italicum).
OH NCBI_TaxID=91525; Sorghum arundinaceum.
OH NCBI_TaxID=4558; Sorghum bicolor (Sorghum) (Sorghum vulgare).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=8317107; DOI=10.1006/viro.1993.1343;
RA Manohar S.K., Guilley H., Dollet M., Richards K., Jonard G.;
RT "Nucleotide sequence and genetic organization of peanut clump virus RNA 2
RT and partial characterization of deleted forms.";
RL Virology 195:33-41(1993).
RN [2]
RP FUNCTION.
RX PubMed=9721240; DOI=10.1006/viro.1998.9287;
RA Herzog E., Hemmer O., Hauser S., Meyer G., Bouzoubaa S., Fritsch C.;
RT "Identification of genes involved in replication and movement of peanut
RT clump virus.";
RL Virology 248:312-322(1998).
CC -!- FUNCTION: Participates in the transport of viral genome to neighboring
CC plant cells directly through plasmodesmata, without any budding. TGBp2
CC and TGBp3 are necessary for intracellular delivery of TGBp1-containing
CC vRNPs to plasmodesmata. Can gate plasmodesmata and increase their size
CC exclusion limit. Induces host actin cytoskeleton network thickening,
CC which probably plays a major role in virus cell-to-cell movement.
CC {ECO:0000250|UniProtKB:P04868}.
CC -!- SUBUNIT: Interacts with movement proteins TGB1 and TGB2. TGB1-TGB3-TGB2
CC complex formation is enhanced by ATP hydrolysis.
CC {ECO:0000250|UniProtKB:P04868}.
CC -!- SUBCELLULAR LOCATION: Host cell junction, host plasmodesma
CC {ECO:0000250|UniProtKB:P04868}. Host endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P04868}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9IV52}. Host cytoplasm, host cytoskeleton
CC {ECO:0000250|UniProtKB:P04868}. Note=Probably localizes to
CC plasmodesmata-associated membrane compartments called peripheral
CC membrane bodies (PMBs). Associates with host actin filaments.
CC {ECO:0000250|UniProtKB:P04868}.
CC -!- DOMAIN: The 2nd transmembrane domain is involved in plasmodesmata
CC targeting. {ECO:0000250|UniProtKB:Q9IV52}.
CC -!- SIMILARITY: Belongs to the virgaviridae TGB3 movement protein family.
CC {ECO:0000305}.
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DR EMBL; L07269; AAA17440.1; -; Unassigned_DNA.
DR RefSeq; NP_620032.1; NC_003668.1.
DR SMR; Q08552; -.
DR GeneID; 991037; -.
DR KEGG; vg:991037; -.
DR Proteomes; UP000001668; Genome.
DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR InterPro; IPR007617; Viral_beta_CD.
DR Pfam; PF04530; Viral_Beta_CD; 1.
PE 3: Inferred from homology;
KW Host cell junction; Host cytoplasm; Host cytoskeleton;
KW Host endoplasmic reticulum; Host membrane; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW Viral movement protein.
FT CHAIN 1..153
FT /note="Movement protein TGB3"
FT /id="PRO_0000409151"
FT TOPO_DOM 1..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9IV52"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q9IV52"
FT TOPO_DOM 72..127
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q9IV52"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q9IV52"
FT TOPO_DOM 149..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9IV52"
SQ SEQUENCE 153 AA; 16830 MW; CEBD13C014273DB1 CRC64;
MEAPAITHSS GCVCSDCQWS GSPTVDTKVY LGSGTHANTT KTRETSFLSV LNDNAWLFVI
AALILCLYFI ISKPHVDAVY TEFHQDLNGF SMKLAPGVPI DPKVIAAVKN WQKYPFGTDP
RENMVTSIVS GLRHSFCILL LVVVLLVYVC HKP