ID   TGB3_PVSP               Reviewed;          65 AA.
AC   P16652;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   07-OCT-2020, entry version 58.
DE   RecName: Full=Movement protein TGBp3;
DE   AltName: Full=7 kDa protein;
DE   AltName: Full=Triple gene block 3 protein;
DE            Short=TGBp3;
GN   ORFNames=ORF4;
OS   Potato virus S (strain Peruvian).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Betaflexiviridae; Quinvirinae; Carlavirus.
OX   NCBI_TaxID=12170;
OH   NCBI_TaxID=4113; Solanum tuberosum (Potato).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2732711; DOI=10.1099/0022-1317-70-5-1053;
RA   Mackenzie D.J., Tremaine J.H., Stace-Smith R.;
RT   "Organization and interviral homologies of the 3'-terminal portion of
RT   potato virus S RNA.";
RL   J. Gen. Virol. 70:1053-1063(1989).
CC   -!- FUNCTION: Plays a role in viral cell-to-cell propagation, by
CC       facilitating genome transport to neighboring plant cells through
CC       plasmosdesmata. May induce the formation of granular vesicles derived
CC       from the Endoplasmic reticulum, which align on actin filaments (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC       cell propagation. TGBp1 is the main movement protein that physically
CC       cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC       facilitate TGBp1 function.
CC   -!- SIMILARITY: Belongs to the Tymovirales TGBp3 protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D00461; BAA00354.1; -; Genomic_RNA.
DR   PIR; JA0126; JA0126.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR003411; TGBp3.
DR   Pfam; PF02495; TGBp3; 1.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport; Viral movement protein.
FT   CHAIN           1..65
FT                   /note="Movement protein TGBp3"
FT                   /id="PRO_0000222617"
FT   TOPO_DOM        1..6
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        27..65
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   65 AA;  7239 MW;  BA43D079565FA964 CRC64;
     MLPKMQPSAQ CLIVFSLAFV LGWYVLRPGN TSCVLLITGE SVRLVNCELT KDLVEAVLLR
     PLKHL