ID   TGB3_PVXX3              Reviewed;          70 AA.
AC   P17781;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   02-DEC-2020, entry version 68.
DE   RecName: Full=Movement protein TGBp3;
DE   AltName: Full=7 kDa protein;
DE   AltName: Full=Triple gene block 3 protein;
DE            Short=TGBp3;
GN   ORFNames=ORF4;
OS   Potato virus X (strain X3) (PVX).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Alphaflexiviridae; Potexvirus.
OX   NCBI_TaxID=12185;
OH   NCBI_TaxID=3711; Brassica campestris (Field mustard).
OH   NCBI_TaxID=4113; Solanum tuberosum (Potato).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3404114; DOI=10.1099/0022-1317-69-8-1789;
RA   Huisman M.J., Linthorst H.J.M., Bol J.F., Cornelissen B.J.C.;
RT   "The complete nucleotide sequence of potato virus X and its homologies at
RT   the amino acid level with various plus-stranded RNA viruses.";
RL   J. Gen. Virol. 69:1789-1798(1988).
RN   [2]
RP   FUNCTION.
RX   PubMed=12726734; DOI=10.1016/s0042-6822(02)00102-2;
RA   Krishnamurthy K., Heppler M., Mitra R., Blancaflor E., Payton M.,
RA   Nelson R.S., Verchot-Lubicz J.;
RT   "The Potato virus X TGBp3 protein associates with the ER network for virus
RT   cell-to-cell movement.";
RL   Virology 309:135-151(2003).
RN   [3]
RP   FUNCTION.
RX   PubMed=21474436; DOI=10.1104/pp.111.174110;
RA   Ye C., Dickman M.B., Whitham S.A., Payton M., Verchot J.;
RT   "The unfolded protein response is triggered by a plant viral movement
RT   protein.";
RL   Plant Physiol. 156:741-755(2011).
RN   [4]
RP   REVIEW.
RX   PubMed=15828680; DOI=10.1094/mpmi-18-0283;
RA   Verchot-Lubicz J.;
RT   "A new cell-to-cell transport model for Potexviruses.";
RL   Mol. Plant Microbe Interact. 18:283-290(2005).
CC   -!- FUNCTION: Plays a role in viral cell-to-cell propagation, by
CC       facilitating genome transport to neighboring plant cells through
CC       plasmosdesmata. May induce the formation of granular vesicles derived
CC       from the endoplasmic reticulum, which align on actin filaments.
CC       {ECO:0000269|PubMed:12726734, ECO:0000269|PubMed:21474436}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane.
CC   -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC       cell propagation. TGBp1 is the main movement protein that physically
CC       cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC       facilitate TGBp1 function.
CC   -!- SIMILARITY: Belongs to the Tymovirales TGBp3 protein family.
CC       {ECO:0000305}.
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DR   EMBL; D00344; BAA00252.1; -; Genomic_RNA.
DR   PIR; JA0105; WMWGP4.
DR   RefSeq; YP_002332932.1; NC_011620.1.
DR   PRIDE; P17781; -.
DR   GeneID; 7065757; -.
DR   KEGG; vg:7065757; -.
DR   Proteomes; UP000008687; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR003411; TGBp3.
DR   Pfam; PF02495; TGBp3; 1.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Viral movement protein.
FT   CHAIN           1..70
FT                   /note="Movement protein TGBp3"
FT                   /id="PRO_0000222607"
FT   TOPO_DOM        1..4
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        5..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..70
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   70 AA;  7595 MW;  E6F76D2D7F300D7F CRC64;
     MEVNTYLNAI ILVLVVTIIA VISTSLVRTE PCVIKITGES ITVLACKLDA ETIKAIADLK
     PLSVERLSFH