ID   TGB3_WCMVM              Reviewed;          66 AA.
AC   P09501;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   07-OCT-2020, entry version 83.
DE   RecName: Full=Movement protein TGBp3;
DE   AltName: Full=7 kDa protein;
DE   AltName: Full=Triple gene block 3 protein;
DE            Short=TGBp3;
GN   ORFNames=ORF4;
OS   White clover mosaic virus (strain M) (WCMV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Alphaflexiviridae; Potexvirus.
OX   NCBI_TaxID=12189;
OH   NCBI_TaxID=3898; Trifolium.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3340527; DOI=10.1093/nar/16.1.291;
RA   Forster R.L.S., Bevan M.W., Harbison S.-A., Gardner R.C.;
RT   "The complete nucleotide sequence of the potexvirus white clover mosaic
RT   virus.";
RL   Nucleic Acids Res. 16:291-303(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3341118; DOI=10.1016/0042-6822(88)90487-4;
RA   Harbison S.-A., Forster R.L.S., Guilford P.J., Gardner R.C.;
RT   "Organization and interviral homologies of the coat protein gene of white
RT   clover mosaic virus.";
RL   Virology 162:459-465(1988).
RN   [3]
RP   REVIEW.
RX   PubMed=15828680; DOI=10.1094/mpmi-18-0283;
RA   Verchot-Lubicz J.;
RT   "A new cell-to-cell transport model for Potexviruses.";
RL   Mol. Plant Microbe Interact. 18:283-290(2005).
CC   -!- FUNCTION: Plays a role in viral cell-to-cell propagation, by
CC       facilitating genome transport to neighboring plant cells through
CC       plasmosdesmata. May induce the formation of granular vesicles derived
CC       from the Endoplasmic reticulum, which align on actin filaments (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-
CC       cell propagation. TGBp1 is the main movement protein that physically
CC       cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would
CC       facilitate TGBp1 function.
CC   -!- SIMILARITY: Belongs to the Tymovirales TGBp3 protein family.
CC       {ECO:0000305}.
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DR   EMBL; X06728; CAA29907.1; -; Genomic_RNA.
DR   EMBL; M18920; AAA69637.1; -; Genomic_RNA.
DR   PIR; C34002; C34002.
DR   RefSeq; NP_620718.1; NC_003820.1.
DR   GeneID; 944397; -.
DR   KEGG; vg:944397; -.
DR   Proteomes; UP000007627; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   InterPro; IPR003411; TGBp3.
DR   Pfam; PF02495; TGBp3; 1.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Viral movement protein.
FT   CHAIN           1..66
FT                   /note="Movement protein TGBp3"
FT                   /id="PRO_0000222610"
FT   TOPO_DOM        1..2
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        24..66
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   66 AA;  7220 MW;  9D42ECD63F7830D5 CRC64;
     MDFTTLIIIG VYLLVFIVYF AKINTSVCTI SISGASIEIS GCDNPTLFEI LPKLRPFNHG
     LSLPSN