ID   TGFA1_DANRE             Reviewed;         863 AA.
AC   A4IG72;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Transforming growth factor-beta receptor-associated protein 1 homolog;
DE            Short=TGF-beta receptor-associated protein 1 homolog;
GN   Name=tgfbrap1; ORFNames=zgc:162302;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=WIK; TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the TGF-beta signaling pathway.
CC       {ECO:0000250|UniProtKB:Q8WUH2}.
CC   -!- FUNCTION: Plays a role in vesicle-mediated protein trafficking of the
CC       endocytic membrane transport pathway. Believed to act as a component of
CC       the putative CORVET endosomal tethering complexes which is proposed to
CC       be involved in the Rab5-to-Rab7 endosome conversion probably
CC       implicating MON1A/B, and via binding SNAREs and SNARE complexes to
CC       mediate tethering and docking events during SNARE-mediated membrane
CC       fusion. The CORVET complex is proposed to function as a Rab5 effector
CC       to mediate early endosome fusion probably in specific endosome
CC       subpopulations (By similarity). {ECO:0000250|UniProtKB:Q8WUH2}.
CC   -!- SUBUNIT: Component of the putative class C core vacuole/endosome
CC       tethering (CORVET) complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q8WUH2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Early endosome
CC       {ECO:0000250|UniProtKB:Q8WUH2}.
CC   -!- SIMILARITY: Belongs to the TRAP1 family. {ECO:0000305}.
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DR   EMBL; BC134956; AAI34957.1; -; mRNA.
DR   RefSeq; NP_001077023.1; NM_001083554.1.
DR   AlphaFoldDB; A4IG72; -.
DR   STRING; 7955.ENSDARP00000082230; -.
DR   PaxDb; A4IG72; -.
DR   PeptideAtlas; A4IG72; -.
DR   GeneID; 565026; -.
DR   KEGG; dre:565026; -.
DR   CTD; 9392; -.
DR   ZFIN; ZDB-GENE-070410-66; tgfbrap1.
DR   eggNOG; KOG2063; Eukaryota.
DR   InParanoid; A4IG72; -.
DR   OrthoDB; 682722at2759; -.
DR   PhylomeDB; A4IG72; -.
DR   PRO; PR:A4IG72; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IBA:GO_Central.
DR   GO; GO:0034058; P:endosomal vesicle fusion; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR032914; Vam6/VPS39/TRAP1.
DR   InterPro; IPR019452; VPS39/TGF_beta_rcpt-assoc_1.
DR   InterPro; IPR019453; VPS39/TGF_beta_rcpt-assoc_2.
DR   PANTHER; PTHR12894; PTHR12894; 1.
DR   Pfam; PF00637; Clathrin; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF10366; Vps39_1; 1.
DR   Pfam; PF10367; Vps39_2; 1.
DR   PROSITE; PS50236; CHCR; 1.
DR   PROSITE; PS50219; CNH; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Reference proteome.
FT   CHAIN           1..863
FT                   /note="Transforming growth factor-beta receptor-associated
FT                   protein 1 homolog"
FT                   /id="PRO_0000345407"
FT   DOMAIN          23..297
FT                   /note="CNH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00795"
FT   REPEAT          564..729
FT                   /note="CHCR"
SQ   SEQUENCE   863 AA;  97048 MW;  77147BF06E4ED5E6 CRC64;
     MSVKAFDLVP AVEREQVMGE KVRINIECIE CCGQHLYLGT NDCFIHHFLL EEHTTAKGKL
     AFNAQKLLHK YLGLKKPVVE LKAASALERL IVLCDSAITV VDMVTLEPVP TGGAKLKGVT
     AFCINENPVT GDAFCVEMAV VLARRRAVQI CTVHEDRVQM LKEVTTPEQP CALSLDGYNI
     CLALSTQYMI LNYSTGASQD LFPYDCEERK PIVKRIGREE FLLAAPGGLG MFANAEGISQ
     RAPVSWSENV IAAAVCFPYV VALDEGFVTV HSMLDQQLKQ TLSFRDGQLL QDFEGKVVVA
     SSKAVYMLVP LPLERQIQDL LASHRVEEAL TLTEAAQRNI PKEKYQILHR RILQQAGFIQ
     FGQLQFLEAK EHFRKGQLDV RELISLYPLL LPASSSFTRC HPPLHEFADL NHLTQGDQEK
     VQRFKRFLIS YLHEVRSSDI ANGFHEDVDT ALLKLYAETS HESLLDLLAS ENACLLADSA
     PWLEKHHKYY ALGLLYHYNG QDAAALQMWV KIVNGDLQDS TRPDLFEYVV DFLSFCSNLD
     LVWRHADWAL QKDQKIGVQI FTKRPTSEER RGQLNADDVI TYLQKHSQAL LLYLEHLVLE
     KKLQKEKYHT HLAVLYAEKV LGLISRPSTS EEQLSAARQK LQRLLKESNL YRVQLLLGKI
     QDSELLLLER ATLHGKLEEH DKALHVLVHQ LKDSSAAEEY CSWASASQDS SYRQNLFHQL
     LSVYLDPDVP GGAQTVAAVD LLNRHAEVFD AVRVLKLLPE DWSLPLLRPF LCGAMRATVH
     ARCTSQVALG LARAQNLQLL HDRLKYRGGP VLVSEKKGCQ LCHNTFSEPD CACLPGGTPV
     HINCVAKKAL DLPHENAHHS NHT