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BRE1_KLULA
ID   BRE1_KLULA              Reviewed;         663 AA.
AC   Q6CWM4;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=E3 ubiquitin-protein ligase BRE1;
DE            EC=2.3.2.27 {ECO:0000250|UniProtKB:Q07457};
DE   AltName: Full=RING-type E3 ubiquitin transferase BRE1 {ECO:0000305};
GN   Name=BRE1; OrderedLocusNames=KLLA0B02981g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: E3 ubiquitin-protein ligase that mediates monoubiquitination
CC       of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for
CC       epigenetic transcriptional activation and is also a prerequisite for
CC       H3K4me and H3K79me formation. {ECO:0000250|UniProtKB:Q07457}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000250|UniProtKB:Q07457};
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q07457}.
CC   -!- SIMILARITY: Belongs to the BRE1 family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH02058.1; -; Genomic_DNA.
DR   RefSeq; XP_451665.1; XM_451665.1.
DR   AlphaFoldDB; Q6CWM4; -.
DR   SMR; Q6CWM4; -.
DR   STRING; 28985.XP_451665.1; -.
DR   EnsemblFungi; CAH02058; CAH02058; KLLA0_B02981g.
DR   GeneID; 2897020; -.
DR   KEGG; kla:KLLA0_B02981g; -.
DR   eggNOG; KOG0978; Eukaryota.
DR   HOGENOM; CLU_019713_1_0_1; -.
DR   InParanoid; Q6CWM4; -.
DR   OMA; DVVYFQK; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:1990302; C:Bre1-Rad6 ubiquitin ligase complex; IEA:EnsemblFungi.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:EnsemblFungi.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:EnsemblFungi.
DR   GO; GO:0010390; P:histone monoubiquitination; IEA:EnsemblFungi.
DR   GO; GO:0042138; P:meiotic DNA double-strand break formation; IEA:EnsemblFungi.
DR   GO; GO:0031571; P:mitotic G1 DNA damage checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:0070534; P:protein K63-linked ubiquitination; IEA:EnsemblFungi.
DR   GO; GO:0030174; P:regulation of DNA-templated DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:0031509; P:subtelomeric heterochromatin assembly; IEA:EnsemblFungi.
DR   GO; GO:0000722; P:telomere maintenance via recombination; IEA:EnsemblFungi.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR013956; E3_ubiquit_lig_Bre1.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR23163; PTHR23163; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Coiled coil; Metal-binding; Nucleus;
KW   Reference proteome; Transferase; Ubl conjugation pathway; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..663
FT                   /note="E3 ubiquitin-protein ligase BRE1"
FT                   /id="PRO_0000055853"
FT   ZN_FING         611..650
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          176..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          273..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          133..172
FT                   /evidence="ECO:0000255"
FT   COILED          225..424
FT                   /evidence="ECO:0000255"
FT   COILED          463..588
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        194..222
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   663 AA;  75282 MW;  2B100CC475302FB6 CRC64;
     MNDHFVKRPK LELSDPSEPL TQKDVIAFQK EALFRCLNKW RVKANQLVEE NEVLAAGLSK
     TTESVSGCCS SIVVLARSVV EDCSDEQDKR FLQQLINTED EHTLTQIISN NSARICELIL
     KTSGSNISDN IGRLQELESL TLTLQKLLKS SENKLKKATE YYENIIAQYD RQDSESVSRV
     FNTADDDSNV KKEKQSSTGA SSVNDESNDN SDKSQSNKES AVSQAHHEIE INDLNTQISV
     LEATVKELTE WKNQNERELS ELRQTVASNK SALSNNQLQS NSQHQPDASV TNEKISSLTK
     QNEQLQQINE GYLTKFQQLS ADREIFNNKL TSEFNLAQET LKKHNASLEK DLVRIRTIRD
     ELLAKVSLLE AQKTKSEMLE DLEKSLNIQQ EQLQKFESRS SENASQDALM KELQDLEKAF
     REVSHLSNKK YAAYLNQESV LSKLTVEKTK ASEKYFAAMR SKDAIMIENK NLSKNLNKSN
     ELIVQLKDLE KTLQQKIVNV HMQLSLSQEN EKRVKESNKE TSMKIVELTS ENNKLKKSTE
     RLESETRNLI GTKTELESKI KDKDIENKQL KIKVSSAEAK SKKLYKTLLS NGGDNGALAE
     ELENFRTIIY CSLCSKNWKN TALKTCGHVF CDVCCKERLA ARMRKCPTCN KPFSSNDLLS
     IHL
 
 
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