ID   TGHH_ORYSJ              Reviewed;         984 AA.
AC   Q67VW6; A0A0P0WX43;
DT   07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=G patch domain-containing protein TGH homolog;
DE   AltName: Full=Protein TOUGH homolog;
GN   OrderedLocusNames=Os06g0489200 {ECO:0000312|EMBL:BAF19586.1},
GN   LOC_Os06g29400 {ECO:0000305};
GN   ORFNames=OsJ_21406 {ECO:0000312|EMBL:EEE65748.1},
GN   P0583E12.23 {ECO:0000312|EMBL:BAD37703.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Functions as component of microRNA (miRNA) and small
CC       interfering RNA (siRNA) biogenesis. May assist Dicer-like (DCL)
CC       proteins to efficiently process and/or recruit the precursors of miRNAs
CC       and siRNAs. {ECO:0000250|UniProtKB:Q8GXN9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8GXN9}.
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DR   EMBL; AP004728; BAD37703.1; -; Genomic_DNA.
DR   EMBL; AP008212; BAF19586.1; -; Genomic_DNA.
DR   EMBL; AP014962; BAS97851.1; -; Genomic_DNA.
DR   EMBL; CM000143; EEE65748.1; -; Genomic_DNA.
DR   EMBL; AK103574; BAG96148.1; -; mRNA.
DR   RefSeq; XP_015643958.1; XM_015788472.1.
DR   AlphaFoldDB; Q67VW6; -.
DR   SMR; Q67VW6; -.
DR   STRING; 4530.OS06T0489200-01; -.
DR   iPTMnet; Q67VW6; -.
DR   PaxDb; Q67VW6; -.
DR   PRIDE; Q67VW6; -.
DR   EnsemblPlants; Os06t0489200-01; Os06t0489200-01; Os06g0489200.
DR   GeneID; 4341077; -.
DR   Gramene; Os06t0489200-01; Os06t0489200-01; Os06g0489200.
DR   KEGG; osa:4341077; -.
DR   eggNOG; KOG2138; Eukaryota.
DR   HOGENOM; CLU_008613_0_0_1; -.
DR   InParanoid; Q67VW6; -.
DR   OMA; PRSKMDS; -.
DR   OrthoDB; 1175081at2759; -.
DR   Proteomes; UP000000763; Chromosome 6.
DR   Proteomes; UP000007752; Chromosome 6.
DR   Proteomes; UP000059680; Chromosome 6.
DR   Genevisible; Q67VW6; OS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0070883; F:pre-miRNA binding; IEA:EnsemblPlants.
DR   GO; GO:0070878; F:primary miRNA binding; IEA:EnsemblPlants.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0035196; P:miRNA processing; IEA:EnsemblPlants.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0010087; P:phloem or xylem histogenesis; IEA:EnsemblPlants.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   GO; GO:0030422; P:siRNA processing; IEA:EnsemblPlants.
DR   Gene3D; 1.10.10.790; -; 1.
DR   InterPro; IPR011666; DUF1604.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR000061; Surp.
DR   InterPro; IPR035967; SWAP/Surp_sf.
DR   Pfam; PF07713; DUF1604; 1.
DR   Pfam; PF01805; Surp; 1.
DR   SMART; SM00648; SWAP; 1.
DR   SUPFAM; SSF109905; SSF109905; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
DR   PROSITE; PS50128; SURP; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Growth regulation; mRNA processing; Nucleus;
KW   Reference proteome; RNA-binding; RNA-mediated gene silencing.
FT   CHAIN           1..984
FT                   /note="G patch domain-containing protein TGH homolog"
FT                   /id="PRO_0000431423"
FT   DOMAIN          160..202
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REPEAT          408..450
FT                   /note="SURP motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00263"
FT   REGION          130..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          464..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          679..717
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          775..806
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          820..984
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          814..859
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        477..491
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        679..699
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        790..806
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        841..862
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        906..920
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        945..972
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   984 AA;  111299 MW;  48A380113E6E459E CRC64;
     MGFDDDDEDL VVYGTPIERE EDTSARKRRA VAEAGQLRAL PAWKQEVRDE EGRRRFHGAF
     TGGFSAGYYN TVGTKEGWTP QTFTSSRKNR AEMKKQSIYS FLDEEDIKDM GGNALETSQQ
     YDTFGFTATE HARKQASKEQ KERPSAIPGP IPDELVVPAT TSIGVKLLMK MGWRQGRSIR
     DAHADSLYES RREARKAFLA LSGTKTGGQK IQVDSHKSDK DDGATESFEE LHASGNTPVY
     VLHPKQDLHG LGFDPFKHAP EFKDRKRLQK SARDRNRSDV SMRGSLLISN SGQYAPGFGI
     GALEELGVED EDIYASGFAY EQMEVDIEPS KTASDSNYKL EDRKRGVFLA FKIASSSEYK
     LERFDPPEIP SDFDGRHKFL TPRQDVNNLS DLAPPEVPAP EDTSLRLLIE GCAAMVARCG
     KHIEDFYKEK SKTNTQFNFL NEGDGCSYYA RKLWEYQQKY IDQQKPDTVQ SKSSDKLTAE
     NRGKILGERP LDRSTKSSSS SFPAKEAIQL QSNLADNFVK PISLDGLPEY EKPFRNDPAK
     QARFEQFLKD KYQGGLRPAN LIPTSTMSDV DRARERLDFE AAAETIEKGK EKKAMDPLSL
     LGLSGINEQR FVSSTESERS IPARDEKSIY PRREEFEWRP SPILCKRFDI VDPFMGKPFH
     VQRPRSKMDS LIFMSESTTR TNEVESSSIA PQHTSVAGAT ETEAKGAATD PEIESSSVQR
     PVDLYKAIFS DDSDDDMAEP LANQPVDPVK TSEDANMVLN RLVAEDFLES LGKELGLDVP
     PEKPTPPNVL FRSETPSTAN AIGISRNRKA ITCQEIKENE SALDKEEIAN ASADVPSDNV
     EELGLKYEKQ EHRAEKSRSR SSHRQTQSGS LDSDSTSDQH RSRERRSRHK IRSGTPGSDS
     SIEHHRSKKR KSHSKHRTRR SRSPYADSSD SQYTKRKHRE KRHHRTRNPD TDSSDHEYEE
     RHKSSSRRSS DKDRSRRRSR HHKR