ID   TGIF1_PANTR             Reviewed;         401 AA.
AC   Q5IS58;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Homeobox protein TGIF1;
DE   AltName: Full=5'-TG-3'-interacting factor 1;
GN   Name=TGIF1; Synonyms=TGIF;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15620360; DOI=10.1016/j.cell.2004.11.040;
RA   Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L.,
RA   Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.;
RT   "Accelerated evolution of nervous system genes in the origin of Homo
RT   sapiens.";
RL   Cell 119:1027-1040(2004).
CC   -!- FUNCTION: Binds to a retinoid X receptor (RXR) responsive element from
CC       the cellular retinol-binding protein II promoter (CRBPII-RXRE).
CC       Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription
CC       activation of the retinoic acid responsive element. Active
CC       transcriptional corepressor of SMAD2. Links the nodal signaling pathway
CC       to the bifurcation of the forebrain and the establishment of ventral
CC       midline structures. May participate in the transmission of nuclear
CC       signals during development and in the adult, as illustrated by the
CC       down-modulation of the RXR alpha activities (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SMAD2 (By similarity). Interacts with CTBP,
CC       SMAD3 and HDAC1. {ECO:0000250, ECO:0000250|UniProtKB:Q15583}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the TALE/TGIF homeobox family. {ECO:0000305}.
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DR   EMBL; AY665270; AAV74308.1; -; mRNA.
DR   RefSeq; NP_001009815.1; NM_001009815.1.
DR   AlphaFoldDB; Q5IS58; -.
DR   BMRB; Q5IS58; -.
DR   SMR; Q5IS58; -.
DR   STRING; 9598.ENSPTRP00000016743; -.
DR   PaxDb; Q5IS58; -.
DR   Ensembl; ENSPTRT00000018072; ENSPTRP00000016743; ENSPTRG00000009838.
DR   GeneID; 455312; -.
DR   KEGG; ptr:455312; -.
DR   CTD; 7050; -.
DR   VGNC; VGNC:7335; TGIF1.
DR   eggNOG; KOG0773; Eukaryota.
DR   GeneTree; ENSGT00940000155230; -.
DR   HOGENOM; CLU_034318_2_0_1; -.
DR   InParanoid; Q5IS58; -.
DR   OrthoDB; 1573375at2759; -.
DR   TreeFam; TF318093; -.
DR   Proteomes; UP000002277; Chromosome 18.
DR   Bgee; ENSPTRG00000009838; Expressed in cortex of kidney and 21 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..401
FT                   /note="Homeobox protein TGIF1"
FT                   /id="PRO_0000049319"
FT   DNA_BIND        164..226
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          78..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          139..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           153..157
FT                   /note="CTBP-binding motif"
SQ   SEQUENCE   401 AA;  43082 MW;  0BEBCEF86C7F9C0F CRC64;
     MVLAQSRVSA GVGSPHCSGS GGGGSDYFPW PASHPGNPQC SFSTAFLASP RLSRGTLAYL
     PPALWSSLAT PSALLGSSCA PPPPPARCPQ PRALSPELGT KAGPRRPHRW ELPRSPSQGA
     QGPAPRRRLM ETMKGIVAAS GSETEDEDSM DIPLDLSSSA GSGKRRRRGN LPKESVQILR
     DWLYEHRYNA YPSEQEKALL SQQTHLSTLQ VCNWFINARR RLLPDMLRKD GKDPNQFTIS
     RRGAKISETS SVESVMGIKN FMPALEETPF HSCTAGPNPT LGRPLSPKPS SPGSVLARPS
     VICHTTVTAL KDVPFSLCQS VGVGQSTDIQ QIAANNFTDT SLMYPEDTCK SGPSTNTQSG
     LFNTPPPTPP DLNQDFSGFQ LLVDVALKRA AEMELQAKLT A