TGL_ALKHC
ID TGL_ALKHC Reviewed; 284 AA.
AC Q9K5W7;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Protein-glutamine gamma-glutamyltransferase {ECO:0000255|HAMAP-Rule:MF_00727};
DE EC=2.3.2.13 {ECO:0000255|HAMAP-Rule:MF_00727};
DE AltName: Full=Transglutaminase {ECO:0000255|HAMAP-Rule:MF_00727};
DE Short=TGase {ECO:0000255|HAMAP-Rule:MF_00727};
GN Name=tgl {ECO:0000255|HAMAP-Rule:MF_00727}; OrderedLocusNames=BH3970;
OS Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS / JCM 9153 / C-125) (Bacillus halodurans).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=272558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
CC -!- FUNCTION: Probably plays a role in the assembly of the spore coat
CC proteins by catalyzing epsilon-(gamma-glutamyl)lysine cross-links.
CC {ECO:0000255|HAMAP-Rule:MF_00727}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-
CC lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:54816,
CC Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:14005,
CC ChEBI:CHEBI:28938, ChEBI:CHEBI:29969, ChEBI:CHEBI:30011,
CC ChEBI:CHEBI:138370; EC=2.3.2.13; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00727};
CC -!- SIMILARITY: Belongs to the bacillus TGase family. {ECO:0000255|HAMAP-
CC Rule:MF_00727}.
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DR EMBL; BA000004; BAB07689.1; -; Genomic_DNA.
DR PIR; B84146; B84146.
DR AlphaFoldDB; Q9K5W7; -.
DR SMR; Q9K5W7; -.
DR STRING; 272558.10176595; -.
DR EnsemblBacteria; BAB07689; BAB07689; BAB07689.
DR KEGG; bha:BH3970; -.
DR eggNOG; ENOG502Z8C5; Bacteria.
DR HOGENOM; CLU_088922_0_0_9; -.
DR OMA; FYAFECA; -.
DR Proteomes; UP000001258; Chromosome.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR HAMAP; MF_00727; Tgl; 1.
DR InterPro; IPR020916; Gln_gamma-glutamylTfrase_bac.
DR Pfam; PF20085; TGL; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Reference proteome; Sporulation; Transferase.
FT CHAIN 1..284
FT /note="Protein-glutamine gamma-glutamyltransferase"
FT /id="PRO_0000213724"
SQ SEQUENCE 284 AA; 32578 MW; 5A5A855E9B064F35 CRC64;
MGNDMIQVAG RPFSLESTTD FGRVERAILQ QMLDSSEWFS YSSMNELRFE LNVRINIMES
AKEMNASQVT FTIFEHASCN PEYWTLTSTG GFLVRSDVRP SDAILDIYRN GTLYGFECAT
AIIIIYYQAI LKSIGQLRFD SIFQHLYLYS WHTHPGLELH TFHADRFLPG DVVYFNNPDF
HPDTPWFRGE NAVVLSDGTF FGHGFGIMTA EQMIQSLNSY RFPGSMQPAY LANLITRISP
LTIRNLLTLQ SDRTTYHYSK AVIHHNLCSI SSMDYQYYLL SLNG