ID   BRE3_CAEBR              Reviewed;         455 AA.
AC   A8XAC4;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Beta-1,4-mannosyltransferase bre-3;
DE            EC=2.4.1.-;
DE   AltName: Full=Bacillus thuringiensis toxin-resistant protein 3;
DE            Short=Bt toxin-resistant protein 3;
GN   Name=bre-3 {ECO:0000250|UniProtKB:Q03562}; ORFNames=CBG10082;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Glycosyltransferase with a proposed role in glycosphingolipid
CC       biosynthesis. Involved in susceptibility to pore-forming crystal toxins
CC       in conjunction with bre-1, bre-2 and bre-4. Involved in resistance to
CC       the nematotoxic C.cinerea galectin Cgl2. Has a role in determining
CC       brood size (By similarity). {ECO:0000250|UniProtKB:Q03562}.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q03562}. Note=In
CC       punctate structures throughout the cell.
CC       {ECO:0000250|UniProtKB:Q03562}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. {ECO:0000255}.
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DR   EMBL; HE601459; CAP29592.3; -; Genomic_DNA.
DR   RefSeq; XP_002641743.1; XM_002641697.1.
DR   AlphaFoldDB; A8XAC4; -.
DR   STRING; 6238.CBG10082; -.
DR   EnsemblMetazoa; CBG10082.1; CBG10082.1; WBGene00031561.
DR   GeneID; 8583737; -.
DR   KEGG; cbr:CBG_10082; -.
DR   CTD; 8583737; -.
DR   WormBase; CBG10082; CBP02470; WBGene00031561; Cbr-bre-3.
DR   eggNOG; ENOG502QTGI; Eukaryota.
DR   HOGENOM; CLU_044554_0_0_1; -.
DR   InParanoid; A8XAC4; -.
DR   OMA; DSDWIVH; -.
DR   OrthoDB; 801915at2759; -.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0019187; F:beta-1,4-mannosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:EnsemblMetazoa.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009636; P:response to toxic substance; IEA:EnsemblMetazoa.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR027389; B_mannosylTrfase_Bre-3/Egh.
DR   InterPro; IPR001173; Glyco_trans_2-like.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR16779; PTHR16779; 1.
DR   Pfam; PF13632; Glyco_trans_2_3; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Glycosyltransferase; Insecticide resistance; Reference proteome;
KW   Transferase.
FT   CHAIN           1..455
FT                   /note="Beta-1,4-mannosyltransferase bre-3"
FT                   /id="PRO_0000324669"
SQ   SEQUENCE   455 AA;  51627 MW;  C5526F664C26D240 CRC64;
     MNCEVKHALH CAVLVAWIVC FAYFCGVFTE PAEGTVPESP VASYGLVWTI CLYLLRFTAL
     LVLPQCLCNL CGLMMFNAFR EKVQLKAAPL LSPFVCFRVV TKGNFPLLVK ENIDANMKTC
     FEAGMENFIF EVVTDKAINL PPNPRVREVV VPTAYRTKSG AKFKARALQY CLEDDVNILQ
     PTDWIVHLDE ETLLTTNAIC GILNFCEDGK HQFGQGVITY ANGDIVNWLT TLSDSFRVAD
     DMGKLRFQFK LFHKPLFGWK GSYVVTQVEA ERDVSYDHGM EGSIAEDCFF SMVAMKHGYT
     FDFIEGEMHE KSPFTMWDFL QQRKRWLQGI LLTVHSSKIA VVHKALLALS LYAWATMPLT
     SLQVFLCPLF PLPRCLPFDF LLSFVGALNL YMYIFGVVKS FSHKYRNSFL RLGMYLAGAL
     MTIPFNILIE NAAVLVGMFG RKDQFYIVNK DIQTV