TGR3L_HUMAN
ID TGR3L_HUMAN Reviewed; 316 AA.
AC H3BV60;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Transforming growth factor-beta receptor type 3-like protein;
DE AltName: Full=TGF-beta receptor type-3-like protein;
DE Short=TGFR-3L;
DE AltName: Full=Transforming growth factor-beta receptor type III-like protein;
DE Short=TGF-beta receptor type III-like protein;
GN Name=TGFBR3L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-120.
RC TISSUE=Leukemia;
RX PubMed=15885500; DOI=10.1016/j.ygeno.2005.02.009;
RA Dalla E., Mignone F., Verardo R., Marchionni L., Marzinotto S.,
RA Lazarevic D., Reid J.F., Marzio R., Klaric E., Licastro D., Marcuzzi G.,
RA Gambetta R., Pierotti M.A., Pesole G., Schneider C.;
RT "Discovery of 342 putative new genes from the analysis of 5'-end-sequenced
RT full-length-enriched cDNA human transcripts.";
RL Genomics 85:739-751(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-316.
RC TISSUE=Oligodendroglioma, and Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AC010336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DR033794; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AI536712; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BG752983; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS58648.1; -.
DR RefSeq; NP_001182188.1; NM_001195259.1.
DR AlphaFoldDB; H3BV60; -.
DR SMR; H3BV60; -.
DR STRING; 9606.ENSP00000457962; -.
DR iPTMnet; H3BV60; -.
DR PhosphoSitePlus; H3BV60; -.
DR BioMuta; TGFBR3L; -.
DR MassIVE; H3BV60; -.
DR PaxDb; H3BV60; -.
DR PeptideAtlas; H3BV60; -.
DR PRIDE; H3BV60; -.
DR Antibodypedia; 77247; 8 antibodies from 5 providers.
DR DNASU; 100507588; -.
DR Ensembl; ENST00000565886.2; ENSP00000457962.1; ENSG00000260001.7.
DR GeneID; 100507588; -.
DR KEGG; hsa:100507588; -.
DR MANE-Select; ENST00000565886.2; ENSP00000457962.1; NM_001195259.2; NP_001182188.1.
DR UCSC; uc021uoa.2; human.
DR CTD; 100507588; -.
DR DisGeNET; 100507588; -.
DR GeneCards; TGFBR3L; -.
DR HGNC; HGNC:44152; TGFBR3L.
DR HPA; ENSG00000260001; Tissue enriched (pituitary).
DR neXtProt; NX_H3BV60; -.
DR OpenTargets; ENSG00000260001; -.
DR VEuPathDB; HostDB:ENSG00000260001; -.
DR eggNOG; ENOG502R0RG; Eukaryota.
DR GeneTree; ENSGT00530000063861; -.
DR HOGENOM; CLU_084653_0_0_1; -.
DR InParanoid; H3BV60; -.
DR OMA; WGLALHR; -.
DR OrthoDB; 1455831at2759; -.
DR PhylomeDB; H3BV60; -.
DR PathwayCommons; H3BV60; -.
DR BioGRID-ORCS; 100507588; 19 hits in 1063 CRISPR screens.
DR ChiTaRS; TGFBR3L; human.
DR GenomeRNAi; 100507588; -.
DR Pharos; H3BV60; Tdark.
DR PRO; PR:H3BV60; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; H3BV60; protein.
DR Bgee; ENSG00000260001; Expressed in pituitary gland and 92 other tissues.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005539; F:glycosaminoglycan binding; IBA:GO_Central.
DR GO; GO:0005024; F:transforming growth factor beta receptor activity; IBA:GO_Central.
DR GO; GO:0005114; F:type II transforming growth factor beta receptor binding; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0001837; P:epithelial to mesenchymal transition; IBA:GO_Central.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.4100; -; 1.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR Pfam; PF00100; Zona_pellucida; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..316
FT /note="Transforming growth factor-beta receptor type 3-like
FT protein"
FT /id="PRO_0000419495"
FT TOPO_DOM 1..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 1..194
FT /note="ZP; truncated"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..201
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..260
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 109..171
FT /evidence="ECO:0000250"
FT CONFLICT 239
FT /note="P -> A (in Ref. 3; BG752983)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 316 AA; 32819 MW; 2EB35119168683AC CRC64;
MGESAAATAS LFQRRRRGRG GRVTFPGGLK GSARFLSFGP PFPAPPAPPF PAAPGPWLRR
PLFSLKLSDT EDVFPRRAGP LEVPADSRVF VQAALARPSP RWGLALHRCS VTPSSRPAPG
PALALLREGC PADTSVAFPP PPPPSPGAAR PARFSFRLRP VFNASVQFLH CQLSRCRRLR
GVRRAPAPLT PPPPPPPSRC LPQDEACADT GSGSAEGLAA DGPHLHTLTQ PIVVTVPRPP
PRPPKSVPGR AVRPEPPAPA PAALEPAPVV ALVLAAFVLG AALAAGLGLV CAHSAPHAPG
PPARASPSGP QPRRSQ
