TGRE1_DICDI
ID TGRE1_DICDI Reviewed; 912 AA.
AC Q54L75;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Tiger protein E1;
DE AltName: Full=Loose aggregate E1 protein;
DE AltName: Full=Transmembrane, IPT, Ig, E-set, Repeat protein E1;
DE Flags: Precursor;
GN Name=tgrE1; Synonyms=lagE1; ORFNames=DDB_G0286851;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=AX4;
RX PubMed=19285397; DOI=10.1016/j.cub.2009.02.037;
RA Benabentos R., Hirose S., Sucgang R., Curk T., Katoh M., Ostrowski E.A.,
RA Strassmann J.E., Queller D.C., Zupan B., Shaulsky G., Kuspa A.;
RT "Polymorphic members of the lag gene family mediate kin discrimination in
RT Dictyostelium.";
RL Curr. Biol. 19:567-572(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Developmentally regulated; with a peak of
CC expression at 16 hours corresponding to the finger stage of
CC development. {ECO:0000269|PubMed:19285397}.
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DR EMBL; FJ374971; ACN54230.1; -; Genomic_DNA.
DR EMBL; AAFI02000090; EAL64023.1; -; Genomic_DNA.
DR RefSeq; XP_637528.1; XM_632436.1.
DR AlphaFoldDB; Q54L75; -.
DR STRING; 44689.DDB0233529; -.
DR PaxDb; Q54L75; -.
DR EnsemblProtists; EAL64023; EAL64023; DDB_G0286851.
DR GeneID; 8625826; -.
DR KEGG; ddi:DDB_G0286851; -.
DR dictyBase; DDB_G0286851; tgrE1.
DR eggNOG; ENOG502RI4S; Eukaryota.
DR HOGENOM; CLU_325834_0_0_1; -.
DR OMA; EFRTISC; -.
DR PhylomeDB; Q54L75; -.
DR PRO; PR:Q54L75; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR Pfam; PF01833; TIG; 2.
DR SUPFAM; SSF81296; SSF81296; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..912
FT /note="Tiger protein E1"
FT /id="PRO_0000393400"
FT TOPO_DOM 23..815
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 816..836
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 837..912
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 532..609
FT /note="IPT/TIG 1"
FT DOMAIN 612..686
FT /note="IPT/TIG 2"
FT DOMAIN 715..796
FT /note="IPT/TIG 3"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 232
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 323
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 356
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 398
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 407
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 568
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 637
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 653
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 658
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 706
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 716
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 763
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 774
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 781
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 809
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 912 AA; 100875 MW; 1B86DD377E39E7AF CRC64;
MKLKHLTIFL FIFIYRFLFV KSDCYLINNE RPETKITKIR CDDQVISILL NPNNRTDATL
EKDTDGKFYF DVVNFPYKDR LCDYTYDIYF LPEIPSLPSV PTIGGSVNFT YNYPCTSVYG
RIKPLNIANK IVTPYNINLD QFTMRIQPGC GDLIINSGSR VIYNASYQTG DIPNKPTIDD
QGNITIQGSN LYNTQIKINS NDPVENLNPT GNLDSTHSTI VFSLPESQYQ GNWTIDVTIC
DVFYKSYLYT FLPIITVMEG VLNDNGGNLT FTGDHLSVNP STTISGHFGG KPISCFAGTS
KSVICSIPSR SEYGGSGYDV PLNVTIGKYT TNTIKISYDL PLIQGVSQRG TSQIFNVSGV
YFSGVISMTI ITGANIKTNI LKKPTPTLEE PGFFIESNNT IFIFLPNNTQ PGFMNLIVGD
GGSKSFTSPR YNFKITPTIT AGQSFKSNTI GGDLIISGIF MRTVDSDGRD VPLTVKSEPG
GPICDPLKDG DGLSFTCVLK SGFGSSHTMN VYYNLLPVGS FVVSYNPPYL ASSDQEKDGT
IQINGNNLGE SVSNSIITVV YLDGSRANGT VVESSHNLLT FQYPAGNKNT ASYLFQLGDQ
ISNMAGPFTL KPVIENNNPA VPCGGGMVTI NGHYFFNYTK DTTTITIGKV PCNISSINVT
TIECVILPNL KSLSPYYTSG SKPLIISSSN SATEKVYQSS ITGYSNYTFA PPTITNTSDI
DQTALITIYG TSFGDANLEI LIDGKPCTQP EINIHTYSSL TCNVTNYDEM LKYNYSNTKF
NISISVDGQY FIAQIFQFKY ESTISYSENK SSGFPNEMYI GIVAIIIFLA LIFFAIKTQV
EKYIEERRAR KAFRSVDNLR LKLREKHAAE IAKHYSFGYE SAPKPNKSYF YDLGKKLSRL
PLIRCCFKEH TD
